LDB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LDB2_HUMAN
• UniProt AC: O43679
• Protein Name: LIM domain-binding protein 2
• Gene Name: LDB2
• Organism: Homo sapiens (Human).
• Sequence Length: 373
• Subcellular Localization: Nucleus .
• Protein Description: Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors..
• Protein Sequence: MSSTPHDPFYSSPFGPFYRRHTPYMVQPEYRIYEMNKRLQSRTEDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGNNANSTGSKKKTTAANLSLSSQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQYDAANGMDDEEDFNNSPALGNNSPWNSKPPATQETKSENPPPQASQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSTPHDPF ------CCCCCCCCC	42.81	24043423
3	Phosphorylation	-----MSSTPHDPFY -----CCCCCCCCCC	44.66	24043423
4	Phosphorylation	----MSSTPHDPFYS ----CCCCCCCCCCC	19.82	24043423
10	Phosphorylation	STPHDPFYSSPFGPF CCCCCCCCCCCCCCC	17.39	24043423
11	Phosphorylation	TPHDPFYSSPFGPFY CCCCCCCCCCCCCCC	31.73	24043423
12	Phosphorylation	PHDPFYSSPFGPFYR CCCCCCCCCCCCCCC	16.93	24043423
18	Phosphorylation	SSPFGPFYRRHTPYM CCCCCCCCCCCCCCC	15.18	24043423
30	Phosphorylation	PYMVQPEYRIYEMNK CCCCCCHHHHHHHHH	14.70	25693802
33	Phosphorylation	VQPEYRIYEMNKRLQ CCCHHHHHHHHHHHH	10.50	25693802
83	Phosphorylation	KRYTIGRTLIPRYFS CEEEECCCCCHHHHC	24.67	22210691
102	Phosphorylation	GGVTDLYYILKHSKE CCEEHHHHHHHCCHH	13.69	22210691
127	Phosphorylation	CDQCTMVTQHGKPMF CCCCEEEEECCEEEE	12.20	27174698
135	Phosphorylation	QHGKPMFTKVCTEGR ECCEEEEEEEECCCC	19.13	27174698
139	Phosphorylation	PMFTKVCTEGRLILE EEEEEEECCCCEEEE	44.45	27174698
161	Phosphorylation	RIKTWHFTIRQYREL CHHHHCCHHHHHHHH	11.45	24719451
192	Phosphorylation	DQLSKNITRMGLTNF HHHHHHCHHCCCCHH	24.81	27174698
197	Phosphorylation	NITRMGLTNFTLNYL HCHHCCCCHHHHHHH	23.66	27174698
200	Phosphorylation	RMGLTNFTLNYLRLC HCCCCHHHHHHHHHH	19.03	27174698
203	Phosphorylation	LTNFTLNYLRLCVIL CCHHHHHHHHHHHHH	9.05	27174698
222	Phosphorylation	ELMSRHKTYNLSPRD HHHHHCCCCCCCHHH	16.12	21406692
223	Phosphorylation	LMSRHKTYNLSPRDC HHHHCCCCCCCHHHH	20.93	21406692
226	Phosphorylation	RHKTYNLSPRDCLKT HCCCCCCCHHHHHHH	17.79	21406692
232	Ubiquitination	LSPRDCLKTCLFQKW CCHHHHHHHHHHHHH	43.45	-
232	Methylation	LSPRDCLKTCLFQKW CCHHHHHHHHHHHHH	43.45	-
232	Acetylation	LSPRDCLKTCLFQKW CCHHHHHHHHHHHHH	43.45	25953088
238	Ubiquitination	LKTCLFQKWQRMVAP HHHHHHHHHHHHCCC	37.65	-
238	Acetylation	LKTCLFQKWQRMVAP HHHHHHHHHHHHCCC	37.65	25953088
241	Methylation	CLFQKWQRMVAPPAE HHHHHHHHHCCCCCC	22.04	-
242	Sulfoxidation	LFQKWQRMVAPPAEP HHHHHHHHCCCCCCC	1.48	21406390
263	Phosphorylation	KRRKRKNSTSSTSNS CCHHCCCCCCCCCCC	32.47	21406692
264	Phosphorylation	RRKRKNSTSSTSNSS CHHCCCCCCCCCCCC	35.77	24719451
265	Phosphorylation	RKRKNSTSSTSNSSA HHCCCCCCCCCCCCC	31.29	21406692
266	Phosphorylation	KRKNSTSSTSNSSAG HCCCCCCCCCCCCCC	35.62	21406692
267	Phosphorylation	RKNSTSSTSNSSAGN CCCCCCCCCCCCCCC	31.52	21406692
268	Phosphorylation	KNSTSSTSNSSAGNN CCCCCCCCCCCCCCC	36.34	21406692
270	Phosphorylation	STSSTSNSSAGNNAN CCCCCCCCCCCCCCC	22.72	21406692
285	Phosphorylation	STGSKKKTTAANLSL CCCCCCCHHHHCCCC	30.46	27080861
285 (in isoform 2)	Phosphorylation	-	30.46	-
286	Phosphorylation	TGSKKKTTAANLSLS CCCCCCHHHHCCCCC	32.43	27080861
291	Phosphorylation	KTTAANLSLSSQVPD CHHHHCCCCCCCCCC	26.47	27080861
293	Phosphorylation	TAANLSLSSQVPDVM HHHCCCCCCCCCCEE	18.49	27080861
306	Phosphorylation	VMVVGEPTLMGGEFG EEEECCCEECCCCCC	25.69	-
306 (in isoform 2)	Phosphorylation	-	25.69	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RLIM	Q9NVW2	PMID:11882901

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LDB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LDB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SSBP4_HUMAN	SSBP4	physical	20211142
LHX4_HUMAN	LHX4	physical	18330356
LMO3_HUMAN	LMO3	physical	18330356
LMO4_HUMAN	LMO4	physical	18330356
RAIN_HUMAN	RASIP1	physical	18330356
RILP_HUMAN	RILP	physical	18330356
SSBP2_HUMAN	SSBP2	physical	18330356
SSBP3_HUMAN	SSBP3	physical	18330356
TSNAX_HUMAN	TSNAX	physical	18330356

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.