dbPTM

KIF24_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KIF24_HUMAN
UniProt AC	Q5T7B8
Protein Name	Kinesin-like protein KIF24
Gene Name	KIF24
Organism	Homo sapiens (Human).
Sequence Length	1368
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Primarily localizes to the mother centriole/basal body and is either absent at daughter centriole.
Protein Description	Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. [PubMed: 21620453 Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle]
Protein Sequence	MASWLYECLCEAELAQYYSHFTALGLQKIDELAKITMKDYSKLGVHDMNDRKRLFQLIKIIKIMQEEDKAVSIPERHLQTSSLRIKSQELRSGPRRQLNFDSPADNKDRNASNDGFEMCSLSDFSANEQKSTYLKVLEHMLPDDSQYHTKTGILNATAGDSYVQTEISTSLFSPNYLSAILGDCDIPIIQRISHVSGYNYGIPHSCIRQNTSEKQNPWTEMEKIRVCVRKRPLGMREVRRGEINIITVEDKETLLVHEKKEAVDLTQYILQHVFYFDEVFGEACTNQDVYMKTTHPLIQHIFNGGNATCFAYGQTGAGKTYTMIGTHENPGLYALAAKDIFRQLEVSQPRKHLFVWISFYEIYCGQLYDLLNRRKRLFAREDSKHMVQIVGLQELQVDSVELLLEVILKGSKERSTGATGVNADSSRSHAVIQIQIKDSAKRTFGRISFIDLAGSERAADARDSDRQTKMEGAEINQSLLALKECIRALDQEHTHTPFRQSKLTQVLKDSFIGNAKTCMIANISPSHVATEHTLNTLRYADRVKELKKGIKCCTSVTSRNRTSGNSSPKRIQSSPGALSEDKCSPKKVKLGFQQSLTVAAPGSTRGKVHPLTSHPPNIPFTSAPKVSGKRGGSRGSPSQEWVIHASPVKGTVRSGHVAKKKPEESAPLCSEKNRMGNKTVLGWESRASGPGEGLVRGKLSTKCKKVQTVQPVQKQLVSRVELSFGNAHHRAEYSQDSQRGTPARPASEAWTNIPPHQKEREEHLRFYHQQFQQPPLLQQKLKYQPLKRSLRQYRPPEGQLTNETPPLFHSYSENHDGAQVEELDDSDFSEDSFSHISSQRATKQRNTLENSEDSFFLHQTWGQGPEKQVAERQQSLFSSPRTGDKKDLTKSWVDSRDPINHRRAALDHSCSPSKGPVDWSRENSTSSGPSPRDSLAEKPYCSQVDFIYRQERGGGSSFDLRKDASQSEVSGENEGNLPSPEEDGFTISLSHVAVPGSPDQRDTVTTPLREVSADGPIQVTSTVKNGHAVPGEDPRGQLGTHAEYASGLMSPLTMSLLENPDNEGSPPSEQLVQDGATHSLVAESTGGPVVSHTVPSGDQEAALPVSSATRHLWLSSSPPDNKPGGDLPALSPSPIRQHPADKLPSREADLGEACQSRETVLFSHEHMGSEQYDADAEETGLDGSWGFPGKPFTTIHMGVPHSGPTLTPRTGSSDVADQLWAQERKHPTRLGWQEFGLSTDPIKLPCNSENVTWLKPRPISRCLARPSSPLVPSCSPKTAGTLRQPTLEQAQQVVIRAHQEQLDEMAELGFKEETLMSQLASNDFEDFVTQLDEIMVLKSKCIQSLRSQLQLYLTCHGPTAAPEGTVPS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Ubiquitination	ITMKDYSKLGVHDMN CCCCCHHHCCCCCCC	42.93	29967540
59	Ubiquitination	KRLFQLIKIIKIMQE HHHHHHHHHHHHHCH	47.15	-
69	Ubiquitination	KIMQEEDKAVSIPER HHHCHHCCCCCCCHH	54.70	-
72	Phosphorylation	QEEDKAVSIPERHLQ CHHCCCCCCCHHHHC	36.97	27174698
80	Phosphorylation	IPERHLQTSSLRIKS CCHHHHCCCCEEHHH	27.00	27174698
81	Phosphorylation	PERHLQTSSLRIKSQ CHHHHCCCCEEHHHH	17.89	25159151
82	Phosphorylation	ERHLQTSSLRIKSQE HHHHCCCCEEHHHHH	25.67	27174698
86	Ubiquitination	QTSSLRIKSQELRSG CCCCEEHHHHHHHCC	39.39	29967540
87	Phosphorylation	TSSLRIKSQELRSGP CCCEEHHHHHHHCCC	26.90	24719451
102	Phosphorylation	RRQLNFDSPADNKDR CCCCCCCCCCCCCCC	20.18	25159151
107	Ubiquitination	FDSPADNKDRNASND CCCCCCCCCCCCCCC	59.62	29967540
112	Phosphorylation	DNKDRNASNDGFEMC CCCCCCCCCCCCCCC	38.72	22817900
120	Phosphorylation	NDGFEMCSLSDFSAN CCCCCCCCHHHCCCC	29.60	27251275
130	Ubiquitination	DFSANEQKSTYLKVL HCCCCCCHHHHHHHH	38.29	29967540
131	Phosphorylation	FSANEQKSTYLKVLE CCCCCCHHHHHHHHH	23.21	-
132	Phosphorylation	SANEQKSTYLKVLEH CCCCCHHHHHHHHHH	39.65	-
133	Phosphorylation	ANEQKSTYLKVLEHM CCCCHHHHHHHHHHH	16.18	-
135	Ubiquitination	EQKSTYLKVLEHMLP CCHHHHHHHHHHHCC	34.07	29967540
145	Phosphorylation	EHMLPDDSQYHTKTG HHHCCCCHHHCCCCC	39.76	28555341
205	Phosphorylation	YNYGIPHSCIRQNTS CCCCCCHHHHCCCCC	13.09	28555341
214	Ubiquitination	IRQNTSEKQNPWTEM HCCCCCCCCCCCCHH	55.96	-
219	Phosphorylation	SEKQNPWTEMEKIRV CCCCCCCCHHHHEEE	27.06	-
223	Ubiquitination	NPWTEMEKIRVCVRK CCCCHHHHEEEEECC	34.21	-
251	Ubiquitination	NIITVEDKETLLVHE EEEEECCCCEEEEEC	38.81	29967540
253	Phosphorylation	ITVEDKETLLVHEKK EEECCCCEEEEECCH	31.00	20058876
259	Ubiquitination	ETLLVHEKKEAVDLT CEEEEECCHHHHHHH	40.82	29967540
333	Phosphorylation	THENPGLYALAAKDI CCCCCCHHHHHHHHH	12.89	-
383	Phosphorylation	RLFAREDSKHMVQIV HHHHCCCCCCHHEEE	21.51	22210691
399	Phosphorylation	LQELQVDSVELLLEV CEEECCCHHHHHHHH	20.73	22210691
411	Phosphorylation	LEVILKGSKERSTGA HHHHHHCCCCCCCCC	29.74	22210691
425	Phosphorylation	ATGVNADSSRSHAVI CCCCCCCCCCCEEEE	25.82	-
426	Phosphorylation	TGVNADSSRSHAVIQ CCCCCCCCCCEEEEE	38.05	-
469	Ubiquitination	RDSDRQTKMEGAEIN CCCCHHHHHCHHHHH	26.98	-
478	Phosphorylation	EGAEINQSLLALKEC CHHHHHHHHHHHHHH	22.36	19369195
483	Ubiquitination	NQSLLALKECIRALD HHHHHHHHHHHHHHC	44.95	32015554
494	Phosphorylation	RALDQEHTHTPFRQS HHHCHHCCCCCHHHH	27.05	23186163
496	Phosphorylation	LDQEHTHTPFRQSKL HCHHCCCCCHHHHHH	25.85	23312004
501	Phosphorylation	THTPFRQSKLTQVLK CCCCHHHHHHHHHHH	25.94	24505115
502	Ubiquitination	HTPFRQSKLTQVLKD CCCHHHHHHHHHHHH	47.41	29967540
504	Phosphorylation	PFRQSKLTQVLKDSF CHHHHHHHHHHHHCC	21.99	24505115
508	Ubiquitination	SKLTQVLKDSFIGNA HHHHHHHHHCCCCCC	53.09	29967540
510	Phosphorylation	LTQVLKDSFIGNAKT HHHHHHHCCCCCCCE	19.71	27251275
516	Ubiquitination	DSFIGNAKTCMIANI HCCCCCCCEEEEEEC	46.38	-
524	Phosphorylation	TCMIANISPSHVATE EEEEEECCHHHHHCH	21.84	25159151
551	Ubiquitination	KELKKGIKCCTSVTS HHHHCCCEECCCCCC	31.74	29967540
555	Phosphorylation	KGIKCCTSVTSRNRT CCCEECCCCCCCCCC	14.96	28985074
566	Phosphorylation	RNRTSGNSSPKRIQS CCCCCCCCCCCCCCC	52.09	28985074
567	Phosphorylation	NRTSGNSSPKRIQSS CCCCCCCCCCCCCCC	38.14	28985074
573	Phosphorylation	SSPKRIQSSPGALSE CCCCCCCCCCCCCCC	35.81	25159151
574	Phosphorylation	SPKRIQSSPGALSED CCCCCCCCCCCCCCC	15.81	25159151
579	Phosphorylation	QSSPGALSEDKCSPK CCCCCCCCCCCCCCC	43.12	29255136
584	Phosphorylation	ALSEDKCSPKKVKLG CCCCCCCCCCCEEEC	45.56	29255136
595	Phosphorylation	VKLGFQQSLTVAAPG EEECEEEEEEEECCC	18.41	28122231
597	Phosphorylation	LGFQQSLTVAAPGST ECEEEEEEEECCCCC	17.22	28122231
603	Phosphorylation	LTVAAPGSTRGKVHP EEEECCCCCCCCCCC	17.55	27251275
604	Phosphorylation	TVAAPGSTRGKVHPL EEECCCCCCCCCCCC	49.72	27251275
621	Phosphorylation	HPPNIPFTSAPKVSG CCCCCCCCCCCCCCC	20.72	26290419
622	Phosphorylation	PPNIPFTSAPKVSGK CCCCCCCCCCCCCCC	42.84	26290419
633	Phosphorylation	VSGKRGGSRGSPSQE CCCCCCCCCCCCCCC	35.97	22617229
636	Phosphorylation	KRGGSRGSPSQEWVI CCCCCCCCCCCCEEE	21.92	25159151
638	Phosphorylation	GGSRGSPSQEWVIHA CCCCCCCCCCEEEEE	42.29	25850435
646	Phosphorylation	QEWVIHASPVKGTVR CCEEEEECCCCCEEC	18.96	25159151
651	Phosphorylation	HASPVKGTVRSGHVA EECCCCCEECCCCCC	13.66	21949786
672	Ubiquitination	SAPLCSEKNRMGNKT CCCCCCCCCCCCCEE	33.29	29967540
700	Phosphorylation	GLVRGKLSTKCKKVQ CCCCCCCCCCCCCCC	29.34	-
701	Phosphorylation	LVRGKLSTKCKKVQT CCCCCCCCCCCCCCC	51.39	-
705	Ubiquitination	KLSTKCKKVQTVQPV CCCCCCCCCCCCHHH	49.39	29967540
708	Phosphorylation	TKCKKVQTVQPVQKQ CCCCCCCCCHHHHHH	24.89	-
714	Ubiquitination	QTVQPVQKQLVSRVE CCCHHHHHHHHHEEE	45.92	-
723	Phosphorylation	LVSRVELSFGNAHHR HHHEEEEECCCCHHC	20.01	22817900
780	Ubiquitination	QPPLLQQKLKYQPLK CCCHHHHHHCCCHHH	33.70	-
826	Phosphorylation	QVEELDDSDFSEDSF CEEECCCCCCCCHHH	39.98	-
829	Phosphorylation	ELDDSDFSEDSFSHI ECCCCCCCCHHHHHH	45.55	-
851	Phosphorylation	QRNTLENSEDSFFLH HHHCCCCCCCCCHHH	33.15	17192257
854	Phosphorylation	TLENSEDSFFLHQTW CCCCCCCCCHHHCCC	17.53	17192257
875	Phosphorylation	QVAERQQSLFSSPRT HHHHHHHHHHCCCCC	24.04	23186163
878	Phosphorylation	ERQQSLFSSPRTGDK HHHHHHHCCCCCCCC	44.73	22167270
879	Phosphorylation	RQQSLFSSPRTGDKK HHHHHHCCCCCCCCH	15.86	22167270
891	Phosphorylation	DKKDLTKSWVDSRDP CCHHCCHHHHCCCCC	27.39	17192257
895	Phosphorylation	LTKSWVDSRDPINHR CCHHHHCCCCCCCCH	29.03	19369195
909	Phosphorylation	RRAALDHSCSPSKGP HHHHHCCCCCCCCCC	18.89	25159151
911	Phosphorylation	AALDHSCSPSKGPVD HHHCCCCCCCCCCCC	34.91	25159151
913	Phosphorylation	LDHSCSPSKGPVDWS HCCCCCCCCCCCCCC	33.67	25850435
920	Phosphorylation	SKGPVDWSRENSTSS CCCCCCCCCCCCCCC	25.83	21815630
930	Phosphorylation	NSTSSGPSPRDSLAE CCCCCCCCCCHHHCC	35.77	27794612
956	Phosphorylation	RQERGGGSSFDLRKD ECCCCCCCCCEECCC	30.98	25159151
957	Phosphorylation	QERGGGSSFDLRKDA CCCCCCCCCEECCCC	26.50	25159151
979	Phosphorylation	ENEGNLPSPEEDGFT CCCCCCCCCCCCCCE	48.38	26471730
986	Phosphorylation	SPEEDGFTISLSHVA CCCCCCCEEEEEEEE	18.38	26471730
988	Phosphorylation	EEDGFTISLSHVAVP CCCCCEEEEEEEECC	22.29	26471730
990	Phosphorylation	DGFTISLSHVAVPGS CCCEEEEEEEECCCC	14.77	26471730
997	Phosphorylation	SHVAVPGSPDQRDTV EEEECCCCCCCCCCC	21.16	19369195
1003	Phosphorylation	GSPDQRDTVTTPLRE CCCCCCCCCCCCCEE	23.18	18691976
1005	Phosphorylation	PDQRDTVTTPLREVS CCCCCCCCCCCEEEC	25.45	29255136
1006	Phosphorylation	DQRDTVTTPLREVSA CCCCCCCCCCEEECC	18.91	17192257
1012	Phosphorylation	TTPLREVSADGPIQV CCCCEEECCCCCEEE	18.85	29255136
1020	Phosphorylation	ADGPIQVTSTVKNGH CCCCEEEEEEEECCC	11.42	25850435
1021	Phosphorylation	DGPIQVTSTVKNGHA CCCEEEEEEEECCCC	32.14	25850435
1022	Phosphorylation	GPIQVTSTVKNGHAV CCEEEEEEEECCCCC	26.57	19369195
1079	Phosphorylation	VQDGATHSLVAESTG CCCCCCEEEEEECCC	21.86	18691976
1106	Phosphorylation	QEAALPVSSATRHLW CCCCCCCCCCCCEEE	16.59	26074081
1107	Phosphorylation	EAALPVSSATRHLWL CCCCCCCCCCCEEEE	33.62	26074081
1109	Phosphorylation	ALPVSSATRHLWLSS CCCCCCCCCEEEECC	22.14	26074081
1115	Phosphorylation	ATRHLWLSSSPPDNK CCCEEEECCCCCCCC	19.72	26074081
1116	Phosphorylation	TRHLWLSSSPPDNKP CCEEEECCCCCCCCC	44.70	18691976
1117	Phosphorylation	RHLWLSSSPPDNKPG CEEEECCCCCCCCCC	36.76	20873877
1131	Phosphorylation	GGDLPALSPSPIRQH CCCCCCCCCCCCCCC	25.99	17192257
1133	Phosphorylation	DLPALSPSPIRQHPA CCCCCCCCCCCCCCC	29.59	20363803
1156	Phosphorylation	DLGEACQSRETVLFS CHHHHHHCCCCEEEC	31.78	21815630
1207	Phosphorylation	PHSGPTLTPRTGSSD CCCCCCCCCCCCCHH	17.13	24719451
1210	Phosphorylation	GPTLTPRTGSSDVAD CCCCCCCCCCHHHHH	42.49	17192257
1212	Phosphorylation	TLTPRTGSSDVADQL CCCCCCCCHHHHHHH	23.81	17192257
1213	Phosphorylation	LTPRTGSSDVADQLW CCCCCCCHHHHHHHH	37.13	17192257
1238	Phosphorylation	GWQEFGLSTDPIKLP CHHHCCCCCCCCCCC	31.01	27251275
1239	Phosphorylation	WQEFGLSTDPIKLPC HHHCCCCCCCCCCCC	51.33	22199227
1267	Phosphorylation	SRCLARPSSPLVPSC CHHCCCCCCCCCCCC	38.75	22199227
1268	Phosphorylation	RCLARPSSPLVPSCS HHCCCCCCCCCCCCC	25.57	22199227
1273	Phosphorylation	PSSPLVPSCSPKTAG CCCCCCCCCCCCCCC	21.54	22199227
1275	Phosphorylation	SPLVPSCSPKTAGTL CCCCCCCCCCCCCCC	33.49	22617229
1278	Phosphorylation	VPSCSPKTAGTLRQP CCCCCCCCCCCCCCC	33.43	29083192
1281	Phosphorylation	CSPKTAGTLRQPTLE CCCCCCCCCCCCCHH	19.12	29083192
1314	Phosphorylation	ELGFKEETLMSQLAS HCCCCHHHHHHHHHC	28.93	26074081
1317	Phosphorylation	FKEETLMSQLASNDF CCHHHHHHHHHCCCH	25.75	26074081
1321	Phosphorylation	TLMSQLASNDFEDFV HHHHHHHCCCHHHHH	45.59	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
621	T	Phosphorylation	Kinase	NEK2	P51955	Uniprot
622	S	Phosphorylation	Kinase	NEK2	P51955	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KIF24_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KIF24_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JAK1_HUMAN	JAK1	physical	26496610
CEP97_HUMAN	CEP97	physical	26496610
DOT1L_HUMAN	DOT1L	physical	26496610
AROS_HUMAN	RPS19BP1	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KIF24_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-112; SER-478; SER-636;SER-646; SER-723; SER-878; SER-879; SER-895; SER-911; SER-957;SER-1012; SER-1116; SER-1131; SER-1133 AND SER-1156, AND MASSSPECTROMETRY.	19369195 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102; SER-478; SER-584;SER-636; SER-646; SER-851; SER-854; SER-879; SER-891; SER-956;SER-957; THR-1005; THR-1006; SER-1012; SER-1156; THR-1210; SER-1212AND SER-1213, AND MASS SPECTROMETRY.	18691976 [Abstract]