KDM5A_MOUSE - dbPTM
KDM5A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KDM5A_MOUSE
UniProt AC Q3UXZ9
Protein Name Lysine-specific demethylase 5A
Gene Name Kdm5a
Organism Mus musculus (Mouse).
Sequence Length 1690
Subcellular Localization Nucleus, nucleolus . Nucleus . Occupies promoters of genes involved in RNA metabolism and mitochondrial function.
Protein Description Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. [PubMed: 17320161]
Protein Sequence MASVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPFAEKTGICKIRPPKDWQPPFACEVKTFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEIVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMGVQMPDLDLKEKVEAEVLSTDIQPSPERGTRMNIPPKRTRRVKSQSDSGEVNRNTELKKLQIFGAGPKVVGLAVGAKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLLPPLPDVPKGDWRCPKCVAEECNKPREAFGFEQAVREYTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPKKDGQRKMLPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVVMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCSCPMQNKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVNRVTEALSASFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCGSVAQLLLSKKQKHRQSSDSGKTRTKLTVEELKAFVQQLVSLPCVISQTRQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAKVCLQARPRHSMANLENIVNEAKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGNNYAYLEQLESLSAKGRPIPVRLDALPQVESQVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTDIGVYGSGKNRRKKVKEIIEKEKEKDLDLEPLSDLEEGLEESRDTAMVVAVFKEREQKEIEAMHSLRAANLAKMTIVERIEEVKFCICRKTASGFMLQCELCKDWFHNSCVPLPKSSSQKKGSSWQAKDVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDKARQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSAFNRVVSSVSSSPHQTMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSIEEKPLKMKGKDSSEKKRKRKLEKVEQLFGEGKQKTKELKKIDKPKKKKLKLNVDKSKELNKLAKKLAKEEERKKKKEKAAAAKVELVKESTEKKRERKVLDIPSKYDWSGAEESDDENAVCAAQNCQRPCKDKVDWVQCDGGCDEWFHQVCVGVSAEMAENEDYICINCAKKQGPDSPGQAPPPPFLMSYKLPMEDLKETS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
84PhosphorylationLNELEAMTRVRLDFL
HHHHHHHHHHCHHHH		32.8119367708
121PhosphorylationILDLYALSKIVASKG
HHHHHHHHHHHHCCC		16.50-
126PhosphorylationALSKIVASKGGFEIV
HHHHHHHCCCCEEEE		22.42-
144PhosphorylationKKWSKVGSRLGYLPG
CCHHCCCHHCCCCCC		27.5923140645
198PhosphorylationKVEAEVLSTDIQPSP
HHEEEECCCCCCCCC		29.2525619855
199PhosphorylationVEAEVLSTDIQPSPE
HEEEECCCCCCCCCC		32.7230635358
204PhosphorylationLSTDIQPSPERGTRM
CCCCCCCCCCCCCCC		24.0225521595
209PhosphorylationQPSPERGTRMNIPPK
CCCCCCCCCCCCCCC		32.7323984901
223PhosphorylationKRTRRVKSQSDSGEV
CCCCCCCCCCCCCCC		31.8725266776
225PhosphorylationTRRVKSQSDSGEVNR
CCCCCCCCCCCCCCC		40.6123684622
227PhosphorylationRVKSQSDSGEVNRNT
CCCCCCCCCCCCCCH		41.9429550500
643PhosphorylationCKELTLMTEEETRLR
HHHHHCCCHHHHHHH		43.2722871156
822PhosphorylationGKTRTKLTVEELKAF
CCCCCCCCHHHHHHH		27.6821183079
950PhosphorylationAELQELLTVSERWEE
HHHHHHHHHHHHHHH		34.3126643407
952PhosphorylationLQELLTVSERWEEKA
HHHHHHHHHHHHHHH		19.0626643407
993PhosphorylationAFLPNVLSLKEALQK
HHHHHHHCHHHHHHH		32.8630387612
1085PhosphorylationTDIGVYGSGKNRRKK
CCEECCCCCCCHHHH		28.9819367708
1111PhosphorylationDLDLEPLSDLEEGLE
CCCCCCCCHHHHHHH		51.3627818261
1120PhosphorylationLEEGLEESRDTAMVV
HHHHHHHHHHHHHEE		26.5329119230
1330PhosphorylationRVVSSVSSSPHQTMD
HHHHCCCCCCCCCCC		45.81-
1331PhosphorylationVVSSVSSSPHQTMDY
HHHCCCCCCCCCCCC		20.9221183079
1335PhosphorylationVSSSPHQTMDYDDEE
CCCCCCCCCCCCCCC		14.6921149613
1338PhosphorylationSPHQTMDYDDEETDS
CCCCCCCCCCCCCCC		17.9321149613
1343PhosphorylationMDYDDEETDSDEDIR
CCCCCCCCCCHHHHH		38.4621149613
1345PhosphorylationYDDEETDSDEDIRET
CCCCCCCCHHHHHHH		50.7721149613
1362PhosphorylationYDMKDTASVKSSSSL
CCCCCCCCCCCCCCC		31.9721183079
1365PhosphorylationKDTASVKSSSSLEPN
CCCCCCCCCCCCCCC		33.0429550500
1366PhosphorylationDTASVKSSSSLEPNL
CCCCCCCCCCCCCCE		20.4429550500
1367PhosphorylationTASVKSSSSLEPNLF
CCCCCCCCCCCCCEE		46.1425195567
1368PhosphorylationASVKSSSSLEPNLFC
CCCCCCCCCCCCEEC		38.4025195567
1423PhosphorylationPRKQPRKSPLVPRSL
CCCCCCCCCCCCCCC		25.4229472430
1438PhosphorylationEPPVLELSPGAKAQL
CCCEEECCCCHHHHH		16.35-
1476PhosphorylationLQATHPPSEDRFLHI
HHCCCCCCCCCCCCC		57.49-
1488PhosphorylationLHIMEDDSIEEKPLK
CCCCCCCCCCCCCCC		44.1924704852
1521AcetylationEQLFGEGKQKTKELK
HHHHCCCHHHHHHHH		44.3023806337
1532AcetylationKELKKIDKPKKKKLK
HHHHCCCCCCHHCCC		63.317744173
1593PhosphorylationRKVLDIPSKYDWSGA
HHCCCCCCCCCCCCC		44.1523984901
1595PhosphorylationVLDIPSKYDWSGAEE
CCCCCCCCCCCCCCC		27.2925521595
1598PhosphorylationIPSKYDWSGAEESDD
CCCCCCCCCCCCCCC		25.8127087446
1603PhosphorylationDWSGAEESDDENAVC
CCCCCCCCCCHHCCH		41.7025521595
1666PhosphorylationAKKQGPDSPGQAPPP
HHHCCCCCCCCCCCC		33.7821082442
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KDM5A_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KDM5A_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KDM5A_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SUZ12_MOUSESuz12physical
20064375
GPN3_HUMANGPN3physical
26496610
EMSY_HUMANC11orf30physical
26496610
PHF12_HUMANPHF12physical
26496610
E41L5_HUMANEPB41L5physical
26496610
GATD1_HUMANGATAD1physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KDM5A_MOUSE

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.;
Immunity 30:143-154(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1111, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory