dbPTM

KCNC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KCNC1_HUMAN
UniProt AC	P48547
Protein Name	Potassium voltage-gated channel subfamily C member 1
Gene Name	KCNC1
Organism	Homo sapiens (Human).
Sequence Length	511
Subcellular Localization	Cell membrane Multi-pass membrane protein .
Protein Description	Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. [PubMed: 25401298 Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.]
Protein Sequence	MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRAGRKPLRGMSI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Phosphorylation	LAEPDAHSHFDYDPR ECCCCCCCCCCCCCC	27.80	27732954
48	Phosphorylation	DAHSHFDYDPRADEF CCCCCCCCCCCCCCC	27.23	27732954
130	Phosphorylation	GGAPLDNSADDADAD CCCCCCCCCCCCCCC	32.51	-
142	Phosphorylation	DADGPGDSGDGEDEL CCCCCCCCCCCHHHH	44.70	-
158	Phosphorylation	MTKRLALSDSPDGRP HHHHHECCCCCCCCC	30.36	27732954
160	Phosphorylation	KRLALSDSPDGRPGG HHHECCCCCCCCCCC	22.86	27732954
188	Phosphorylation	EDPYSSRYARYVAFA CCCCCHHHHHHHHHH	9.44	17053785
220	N-linked_Glycosylation	ERFNPIVNKTEIENV HHHCCCCCHHHEECC	46.37	UniProtKB CARBOHYD
229	N-linked_Glycosylation	TEIENVRNGTQVRYY HHEECCCCCCEEEEE	54.29	UniProtKB CARBOHYD
277	Phosphorylation	KVEFIKNSLNIIDFV HHHHHHHCCCHHHHH	20.14	28348404
296	Phosphorylation	FYLEVGLSGLSSKAA HHHHHCCCCCCHHHH	31.59	28348404
468	Phosphorylation	PRPPQLGSPNYCKSV CCCCCCCCCCCHHHH	20.68	25332170
474	Phosphorylation	GSPNYCKSVVNSPHH CCCCCHHHHHCCCCC	27.95	27732954
478	Phosphorylation	YCKSVVNSPHHSTQS CHHHHHCCCCCCCCC	17.63	27732954
482	Phosphorylation	VVNSPHHSTQSDTCP HHCCCCCCCCCCCCC	25.71	27732954
483	Phosphorylation	VNSPHHSTQSDTCPL HCCCCCCCCCCCCCC	27.95	27732954
485	Phosphorylation	SPHHSTQSDTCPLAQ CCCCCCCCCCCCCCH	34.67	27732954
487	Phosphorylation	HHSTQSDTCPLAQEE CCCCCCCCCCCCHHH	22.67	27732954
570 (in isoform 2)	Phosphorylation	-		25954137
576 (in isoform 2)	Phosphorylation	-		25954137
579 (in isoform 2)	Phosphorylation	-		25954137

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of KCNC1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of KCNC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KCNC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCNG3_HUMAN	KCNG3	physical	12060745
KCNH1_HUMAN	KCNH1	physical	12060745
KCNV2_HUMAN	KCNV2	physical	12060745
DLG1_HUMAN	DLG1	physical	19213956
KCC2A_HUMAN	CAMK2A	physical	19213956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
616187	Epilepsy, progressive myoclonic 7 (EPM7)
Kegg Drug
D01554	Pilsicainide hydrochloride hydrate (JAN); Pilsicainide hydrochloride; SUN 1165 (TN); Sunrythm (TN)
D08377	Pilsicainide (INN)
DrugBank
DB06637	Dalfampridine

Regulatory Network of KCNC1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Tyrosine phosphorylated Par3 regulates epithelial tight junctionassembly promoted by EGFR signaling."; Wang Y., Du D., Fang L., Yang G., Zhang C., Zeng R., Ullrich A.,Lottspeich F., Chen Z.; EMBO J. 25:5058-5070(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-188, AND MASSSPECTROMETRY.	17053785 [Abstract]