KCNV2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNV2_HUMAN
• UniProt AC: Q8TDN2
• Protein Name: Potassium voltage-gated channel subfamily V member 2
• Gene Name: KCNV2
• Organism: Homo sapiens (Human).
• Sequence Length: 545
• Subcellular Localization: Cell membrane; Multi-pass membrane protein. Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1.
• Protein Description: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values..
• Protein Sequence: MLKQSERRRSWSYRPWNTTENEGSQHRRSICSLGARSGSQASIHGWTEGNYNYYIEEDEDGEEEDQWKDDLAEEDQQAGEVTTAKPEGPSDPPALLSTLNVNVGGHSYQLDYCELAGFPKTRLGRLATSTSRSRQLSLCDDYEEQTDEYFFDRDPAVFQLVYNFYLSGVLLVLDGLCPRRFLEELGYWGVRLKYTPRCCRICFEERRDELSERLKIQHELRAQAQVEEAEELFRDMRFYGPQRRRLWNLMEKPFSSVAAKAIGVASSTFVLVSVVALALNTVEEMQQHSGQGEGGPDLRPILEHVEMLCMGFFTLEYLLRLASTPDLRRFARSALNLVDLVAILPLYLQLLLECFTGEGHQRGQTVGSVGKVGQVLRVMRLMRIFRILKLARHSTGLRAFGFTLRQCYQQVGCLLLFIAMGIFTFSAAVYSVEHDVPSTNFTTIPHSWWWAAVSISTVGYGDMYPETHLGRFFAFLCIAFGIILNGMPISILYNKFSDYYSKLKAYEYTTIRRERGEVNFMQRARKKIAECLLGSNPQLTPRQEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	NTTENEGSQHRRSIC CCCCCCCCHHCHHHH	19.35	29759185
194	Phosphorylation	YWGVRLKYTPRCCRI CCEEEEEECCCCCCH	26.94	24719451
195	Phosphorylation	WGVRLKYTPRCCRIC CEEEEEECCCCCCHH	11.58	24719451
323	Phosphorylation	EYLLRLASTPDLRRF HHHHHHCCCHHHHHH	45.10	-
324	Phosphorylation	YLLRLASTPDLRRFA HHHHHCCCHHHHHHH	18.40	-
403	Phosphorylation	GLRAFGFTLRQCYQQ HHHHHCHHHHHHHHH	22.78	24719451
440	N-linked_Glycosylation	EHDVPSTNFTTIPHS CCCCCCCCCCCCCCH	36.28	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCNV2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNV2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNV2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTHR_HUMAN	MTHFR	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442
AMZ2_HUMAN	AMZ2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.