KCNG3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNG3_HUMAN
• UniProt AC: Q8TAE7
• Protein Name: Potassium voltage-gated channel subfamily G member 3
• Gene Name: KCNG3
• Organism: Homo sapiens (Human).
• Sequence Length: 436
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Cytoplasm . Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane (PubMed:12060745). Colocalizes with KCNB1 at the plasma membrane (PubMed:12060745, PubMed:190
• Protein Description: Potassium channel subunit that does not form functional channels by itself. [PubMed: 11852086 Can form functional heterotetrameric channels with KCNB1; this promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1]
• Protein Sequence: MTFGRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELKFRSARYSRSLSTEFLN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	FGRSGAASVVLNVGG CCCCCCEEEEEEECC	16.54	24719451
10	Phosphorylation	FGRSGAASVVLNVGG CCCCCCEEEEEEECC	16.54	24719451
28	Ubiquitination	SLSRELLKDFPLRRV HHCHHHHHHCCHHHH	70.69	-
121	Phosphorylation	RRLDDRMSDTYTFYS HCCCCCCCCCEEEEE	27.91	27732954
123	Phosphorylation	LDDRMSDTYTFYSAD CCCCCCCCEEEEECC	19.70	27732954
124	Phosphorylation	DDRMSDTYTFYSADE CCCCCCCEEEEECCC	10.39	27732954
125	Phosphorylation	DRMSDTYTFYSADEP CCCCCCEEEEECCCC	20.42	27732954
127	Phosphorylation	MSDTYTFYSADEPGV CCCCEEEEECCCCCC	8.64	27732954
128	Phosphorylation	SDTYTFYSADEPGVL CCCEEEEECCCCCCC	25.67	27732954
287	Phosphorylation	QLQRAGVTLRVLRMM HHHHHCHHHHHHHHH	14.13	24719451
287	Phosphorylation	QLQRAGVTLRVLRMM HHHHHCHHHHHHHHH	14.13	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCNG3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNG3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNG3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCNB1_HUMAN	KCNB1	physical	11852086
KCNB2_HUMAN	KCNB2	physical	19074135
KCNB1_HUMAN	KCNB1	physical	19074135

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.