KCNH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNH1_HUMAN
• UniProt AC: O95259
• Protein Name: Potassium voltage-gated channel subfamily H member 1
• Gene Name: KCNH1
• Organism: Homo sapiens (Human).
• Sequence Length: 989
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Nucleus inner membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, axon . Cell junction, synapse, presynaptic cell membrane . Perikaryon . Cell junction, synapse, postsynaptic
• Protein Description: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel. [PubMed: 9738473]
• Protein Sequence: MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPESERDIFGAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Phosphorylation	GELTDKDTIEKVRQT CCCCCHHHHHHHHHH	36.45	23879269
306	Phosphorylation	DLLSCLPYDVINAFE HHHCCCCHHHHHHCC	15.19	-
348	Phosphorylation	RESQGISSLFSSLKV CCCCCHHHHHHHHHH	31.36	30278072
351	Phosphorylation	QGISSLFSSLKVVRL CCHHHHHHHHHHHHH	39.80	30278072
410	Phosphorylation	YEIFDEDTKTIRNNS EECCCCCCCCCCCCH	28.21	-
415	N-linked_Glycosylation	EDTKTIRNNSWLYQL CCCCCCCCCHHHHHH	42.93	UniProtKB CARBOHYD
433	N-linked_Glycosylation	IGTPYQFNGSGSGKW CCCCCEECCCCCCCC	28.35	UniProtKB CARBOHYD
435	Phosphorylation	TPYQFNGSGSGKWEG CCCEECCCCCCCCCC	30.78	-
547	Phosphorylation	IVSTWSMSRGIDTEK HHHHCHHCCCCCHHH	23.10	24719451
552	Phosphorylation	SMSRGIDTEKVLQIC HHCCCCCHHHHHHHC	35.47	24719451
698	Phosphorylation	FSRNLILTYNLRKRI CCCCEEEEEECHHHH	11.90	27067055
699	Phosphorylation	SRNLILTYNLRKRIV CCCEEEEEECHHHHH	14.57	27067055
793	Phosphorylation	SVVTVRESPATPVSF EEEEEECCCCCCCEE	14.85	-
833	Acetylation	GGGGDCAKRKSWARF CCCCCHHCCHHHHHH	67.69	30589777
866	O-linked_Glycosylation	METLPERTKASGEAT HHCCCHHHHCCCCCE	29.33	30379171
899	Phosphorylation	DNVGEARSPQDRSPI CCCCCCCCCCCCCCC	33.68	27732954
904	Phosphorylation	ARSPQDRSPILAEVK CCCCCCCCCCHHHHH	25.28	24719451
959	Phosphorylation	SEILRILTSRRSSQS HHHHHHHHHCCCCCC	20.16	24719451
974	Phosphorylation	PQELFEISRPQSPES HHHHHHCCCCCCCHH	30.61	-
978	Phosphorylation	FEISRPQSPESERDI HHCCCCCCCHHHHCC	33.06	24076635
981	Phosphorylation	SRPQSPESERDIFGA CCCCCCHHHHCCCCC	41.12	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCNH1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SDCB1_HUMAN	SDCBP	physical	25416956
NTAQ1_HUMAN	WDYHV1	physical	25416956
FAKD5_HUMAN	FASTKD5	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.