KCIP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCIP4_HUMAN
• UniProt AC: Q6PIL6
• Protein Name: Kv channel-interacting protein 4
• Gene Name: KCNIP4
• Organism: Homo sapiens (Human).
• Sequence Length: 250
• Subcellular Localization: Cell membrane ; Peripheral membrane protein . Cytoplasm .; Isoform 4: Endoplasmic reticulum .
• Protein Description: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. [PubMed: 11847232]
• Protein Sequence: MNVRRVESISAQLEEASSTGGFLYAQNSTKRSIKERLMKLLPCSAAKTSSPAIQNSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMDKNKDGVVTIDEFIESCQKDENIMRSMQLFENVI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	VRRVESISAQLEEAS HHHHHHHHHHHHHHH	21.17	24719451
17	Phosphorylation	SAQLEEASSTGGFLY HHHHHHHHHCCCCCC	31.54	-
19	Phosphorylation	QLEEASSTGGFLYAQ HHHHHHHCCCCCCCC	38.54	24719451
24	Phosphorylation	SSTGGFLYAQNSTKR HHCCCCCCCCCCCCH	12.13	24719451
30	Acetylation	LYAQNSTKRSIKERL CCCCCCCCHHHHHHH	43.92	18586703
47	Ubiquitination	LLPCSAAKTSSPAIQ HHCCCCCCCCCHHHH	48.97	-
50	Phosphorylation	CSAAKTSSPAIQNSV CCCCCCCCHHHHCCH	24.47	24076635
56	Phosphorylation	SSPAIQNSVEDELEM CCHHHHCCHHHHHHH	15.54	-
91	Phosphorylation	KKELQILYRGFKNEC HHHHHHHHHHHCCCC	15.43	-
129	Phosphorylation	TTYAHFLFNAFDTDH CCHHHHHHHHCCCCC	6.40	-
150	Phosphorylation	EDFIKGLSILLRGTV HHHHHHHHHHHHHHH	21.62	27251275
168	Phosphorylation	LNWAFNLYDINKDGY HHHHHHHHCCCCCCC	18.84	-
189	Phosphorylation	LDIMKAIYDMMGKCT HHHHHHHHHHHCCCC	11.57	24114839

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCIP4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCIP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCIP4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCIP2_HUMAN	KCNIP2	physical	17353931
A4_HUMAN	APP	physical	21832049
KCIP2_HUMAN	KCNIP2	physical	26186194
KCIP1_HUMAN	KCNIP1	physical	26186194
SG1D1_HUMAN	SCGB1D1	physical	26186194
MTX1_HUMAN	MTX1	physical	26186194
LACRT_HUMAN	LACRT	physical	26186194
ZG16B_HUMAN	ZG16B	physical	26186194
PROL4_HUMAN	PRR4	physical	26186194
KCIP2_HUMAN	KCNIP2	physical	28514442
KCIP1_HUMAN	KCNIP1	physical	28514442
MTX1_HUMAN	MTX1	physical	28514442
LACRT_HUMAN	LACRT	physical	28514442
SG1D1_HUMAN	SCGB1D1	physical	28514442
PROL4_HUMAN	PRR4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.