dbPTM

IP3KB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IP3KB_HUMAN
UniProt AC	P27987
Protein Name	Inositol-trisphosphate 3-kinase B
Gene Name	ITPKB
Organism	Homo sapiens (Human).
Sequence Length	946
Subcellular Localization
Protein Description
Protein Sequence	MAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVLSPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLRILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGGPSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTSTGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQSAESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQCPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGALEETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVSKSWRKIKNMVHWSPFVMSFKKKYPWIQLAGHAGSFKAAANGRILKKHCESEQRCLDRLMVDVLRPFVPAYHGDVVKDGERYNQMDDLLADFDSPCVMDCKMGIRTYLEEELTKARKKPSLRKDMYQKMIEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGFRIEGIKKEDGTVNRDFKKTKTREQVTEAFREFTKGNHNILIAYRDRLKAIRTTLEVSPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGKTTPLPEGQTLQHDVPWQEGNREDGYLSGLNNLVDILTEMSQDAPLA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAVYCYALNSL ----CCHHHHHCCCE	3.11	-
22	Phosphorylation	NSANEMKSGGGPGPS CCHHHCCCCCCCCCC	41.16	23403867
29	Phosphorylation	SGGGPGPSGSETPPP CCCCCCCCCCCCCCC	61.95	29255136
31	Phosphorylation	GGPGPSGSETPPPPR CCCCCCCCCCCCCCC	42.51	23401153
33	Phosphorylation	PGPSGSETPPPPRRA CCCCCCCCCCCCCCC	42.67	29255136
39	Methylation	ETPPPPRRAVLSPGS CCCCCCCCCCCCCCC	34.52	58858055
43	Phosphorylation	PPRRAVLSPGSVFSP CCCCCCCCCCCCCCC	22.18	23927012
46	Phosphorylation	RAVLSPGSVFSPGRG CCCCCCCCCCCCCCC	24.31	23927012
49	Phosphorylation	LSPGSVFSPGRGASF CCCCCCCCCCCCCCC	25.04	29255136
52	Methylation	GSVFSPGRGASFLFP CCCCCCCCCCCCCCC	40.67	16186431
55	Phosphorylation	FSPGRGASFLFPPAE CCCCCCCCCCCCCHH	25.88	28060719
63	Phosphorylation	FLFPPAESLSPEEPR CCCCCHHHCCCCCCC	35.93	26657352
65	Phosphorylation	FPPAESLSPEEPRSP CCCHHHCCCCCCCCC	39.27	29255136
71	Phosphorylation	LSPEEPRSPGGWRSG CCCCCCCCCCCCCCC	38.32	28122231
84	Phosphorylation	SGRRRLNSSSGSGSG CCCCCCCCCCCCCCC	30.39	27251789
85	Phosphorylation	GRRRLNSSSGSGSGS CCCCCCCCCCCCCCC	37.33	27273156
86	Phosphorylation	RRRLNSSSGSGSGSS CCCCCCCCCCCCCCC	36.48	28450419
88	Phosphorylation	RLNSSSGSGSGSSGS CCCCCCCCCCCCCCC	31.56	28450419
90	Phosphorylation	NSSSGSGSGSSGSSV CCCCCCCCCCCCCCC	36.88	28857561
92	Phosphorylation	SSGSGSGSSGSSVSS CCCCCCCCCCCCCCC	32.97	28450419
93	Phosphorylation	SGSGSGSSGSSVSSP CCCCCCCCCCCCCCC	46.34	23927012
95	Phosphorylation	SGSGSSGSSVSSPSW CCCCCCCCCCCCCCC	29.52	23312004
96	Phosphorylation	GSGSSGSSVSSPSWA CCCCCCCCCCCCCCC	29.55	23927012
98	Phosphorylation	GSSGSSVSSPSWAGR CCCCCCCCCCCCCCC	38.18	23312004
99	Phosphorylation	SSGSSVSSPSWAGRL CCCCCCCCCCCCCCC	22.31	23312004
101	Phosphorylation	GSSVSSPSWAGRLRG CCCCCCCCCCCCCCC	31.35	23312004
118	Phosphorylation	QQVVAAGTLSPPGPE CEEEEEEECCCCCHH	21.24	25850435
120	Phosphorylation	VVAAGTLSPPGPEEA EEEEEECCCCCHHHH	28.96	26657352
166	Phosphorylation	SAIQAPRSPRLGRAR HHHCCCCCCCCCCCC	17.20	29507054
174	Phosphorylation	PRLGRARSPSPCPFR CCCCCCCCCCCCCCC	28.83	23401153
176	Phosphorylation	LGRARSPSPCPFRSS CCCCCCCCCCCCCCC	40.14	23401153
182	Phosphorylation	PSPCPFRSSSQPPGR CCCCCCCCCCCCCCC	34.42	26699800
183	Phosphorylation	SPCPFRSSSQPPGRV CCCCCCCCCCCCCCE	28.83	26699800
184	Phosphorylation	PCPFRSSSQPPGRVL CCCCCCCCCCCCCEE	48.21	26699800
197	Phosphorylation	VLVQGARSEERRTKS EEEECCCCHHHHCCC	43.19	23403867
202	Phosphorylation	ARSEERRTKSWGEQC CCCHHHHCCCHHHCC	35.33	26657352
204	Phosphorylation	SEERRTKSWGEQCPE CHHHHCCCHHHCCCC	39.43	23401153
212	Phosphorylation	WGEQCPETSGTDSGR HHHCCCCCCCCCCCC	20.00	23927012
213	Phosphorylation	GEQCPETSGTDSGRK HHCCCCCCCCCCCCC	37.72	23927012
215	Phosphorylation	QCPETSGTDSGRKGG CCCCCCCCCCCCCCC	27.10	23927012
217	Phosphorylation	PETSGTDSGRKGGPS CCCCCCCCCCCCCCC	40.09	23927012
227	Phosphorylation	KGGPSLCSSQVKKGM CCCCCCCHHHHHCCC	29.15	-
228	Phosphorylation	GGPSLCSSQVKKGMP CCCCCCHHHHHCCCC	37.69	25159151
264	Phosphorylation	MEKGIPASPRCGSPT ECCCCCCCCCCCCCC	13.92	23403867
269	Phosphorylation	PASPRCGSPTAMEID CCCCCCCCCCCEEEC	23.78	23401153
271	Phosphorylation	SPRCGSPTAMEIDKR CCCCCCCCCEEECCC	40.09	26657352
280	Phosphorylation	MEIDKRGSPTPGTRS EEECCCCCCCCCCHH	29.63	28102081
282	Phosphorylation	IDKRGSPTPGTRSCL ECCCCCCCCCCHHHC	35.73	28102081
352	Phosphorylation	RQGQFLGSETSPAPE HCCCCCCCCCCCCCC	39.59	29255136
354	Phosphorylation	GQFLGSETSPAPERG CCCCCCCCCCCCCCC	41.53	24719451
355	Phosphorylation	QFLGSETSPAPERGG CCCCCCCCCCCCCCC	18.27	29255136
397	Phosphorylation	GKRPEETTVSVQSAE CCCCCCEEEEEECCC	17.67	22468782
440	Phosphorylation	GGGRWQLSDRVEGGS CCCCCCCCCCCCCCC	14.31	28450419
447	Phosphorylation	SDRVEGGSPTLGLLG CCCCCCCCCCEEECC	26.10	26657352
449	Phosphorylation	RVEGGSPTLGLLGGS CCCCCCCCEEECCCC	34.84	29255136
456	Phosphorylation	TLGLLGGSPSAQPGT CEEECCCCCCCCCCC	17.55	29255136
458	Phosphorylation	GLLGGSPSAQPGTGN EECCCCCCCCCCCCC	41.03	29255136
463	Phosphorylation	SPSAQPGTGNVEAGI CCCCCCCCCCCCCCC	32.06	28060719
544	Phosphorylation	QDSDALPSPELLPQD CCCCCCCCHHHCCCC	31.68	28060719
562	Phosphorylation	PFLRKACSPSNIPAV HHHHHHCCCCCCCEE	35.90	27251789
564	Phosphorylation	LRKACSPSNIPAVII HHHHCCCCCCCEEEE	30.97	26029660
572	Phosphorylation	NIPAVIITDMGTQED CCCEEEEECCCCCCC	14.60	28102081
576	Phosphorylation	VIITDMGTQEDGALE EEEECCCCCCCCCCC	23.34	28102081
585	Phosphorylation	EDGALEETQGSPRGN CCCCCCCCCCCCCCC	28.93	24719451
588	Phosphorylation	ALEETQGSPRGNLPL CCCCCCCCCCCCCCH	11.12	27251789
599	Phosphorylation	NLPLRKLSSSSASST CCCHHHCCCCCCCCC	31.07	27251275
600	Phosphorylation	LPLRKLSSSSASSTG CCHHHCCCCCCCCCC	38.45	27251275
601	Phosphorylation	PLRKLSSSSASSTGF CHHHCCCCCCCCCCC	26.92	27251275
602	Phosphorylation	LRKLSSSSASSTGFS HHHCCCCCCCCCCCC	33.83	27251275
604	Phosphorylation	KLSSSSASSTGFSSS HCCCCCCCCCCCCCC	30.31	27251275
605	Phosphorylation	LSSSSASSTGFSSSY CCCCCCCCCCCCCCC	32.06	27251275
606	Phosphorylation	SSSSASSTGFSSSYE CCCCCCCCCCCCCCC	39.49	27251275
609	Phosphorylation	SASSTGFSSSYEDSE CCCCCCCCCCCCCCH	21.51	28348404
610	Phosphorylation	ASSTGFSSSYEDSEE CCCCCCCCCCCCCHH	34.38	28348404
611	Phosphorylation	SSTGFSSSYEDSEED CCCCCCCCCCCCHHH	31.20	28348404
615	Phosphorylation	FSSSYEDSEEDISSD CCCCCCCCHHHHCCC	30.83	28270605
620	Phosphorylation	EDSEEDISSDPERTL CCCHHHHCCCCCCCC	40.80	28270605
621	Phosphorylation	DSEEDISSDPERTLD CCHHHHCCCCCCCCC	58.48	28270605
770	Phosphorylation	PSLRKDMYQKMIEVD HHHCHHHHHHHHHCC	18.34	-
854	Phosphorylation	NHNILIAYRDRLKAI CCEEEEEEHHHHHHH	13.17	19835603

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IP3KB_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IP3KB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IP3KB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSME3_HUMAN	PSME3	physical	16189514
PDE4A_HUMAN	PDE4A	physical	26496610
PDE4D_HUMAN	PDE4D	physical	26496610
PIBF1_HUMAN	PIBF1	physical	26496610
ADNP2_HUMAN	ADNP2	physical	26496610
ESF1_HUMAN	ESF1	physical	26496610

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IP3KB_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43 AND SER-71, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43; SER-49; SER-65;SER-71; SER-174 AND SER-176, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43 AND SER-49, AND MASSSPECTROMETRY.	18088087 [Abstract]