IGBP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IGBP1_MOUSE
• UniProt AC: Q61249
• Protein Name: Immunoglobulin-binding protein 1
• Gene Name: Igbp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 340
• Subcellular Localization: Cytoplasm .
• Protein Description: Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits..
• Protein Sequence: MAASEDELLLPRLPELFETSKKLLEDVEVATEPTGSRTIQDKVSKGLELLEKAAGMLSQLDLFSRNEDLEEIASTDLKYLMVPALQGALTMKQVNPSKRLDHLQRAREHFVHFLTQCHCYHVAEFQLPQTKTNSAENNTASSSMAYPNLVAMASQRQAKIERYKQKKEVEHRLSALKSAVESGQADDERVREYHLLHLRRWIAVSLEELESIDQEIKILKEKDSPREETACHSSLPEKPPMKPFILTRNKAQAKVFGTGYPSLATMTVSDWYEQHQKYGVLPDRGIAKPASADFQRAAQQQEDQEQKDEESEEKALHRMREWDDWKDTHPRGYGNRQNMG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAASEDELLLP ----CCCCHHHCHHH	35.72	26824392
19	Phosphorylation	RLPELFETSKKLLED CHHHHHHHHHHHHHH	38.21	21454597
20	Phosphorylation	LPELFETSKKLLEDV HHHHHHHHHHHHHHC	22.16	25338131
31	Phosphorylation	LEDVEVATEPTGSRT HHHCCCCCCCCCCCC	47.90	21454597
36	Phosphorylation	VATEPTGSRTIQDKV CCCCCCCCCCHHHHH	28.82	21454597
45	Ubiquitination	TIQDKVSKGLELLEK CHHHHHHHHHHHHHH	71.19	-
97	Phosphorylation	TMKQVNPSKRLDHLQ HHHHCCHHHHHHHHH	25.79	24719451
146	Phosphorylation	TASSSMAYPNLVAMA CCCHHCHHHHHHHHH	5.52	29514104
174	Phosphorylation	KEVEHRLSALKSAVE HHHHHHHHHHHHHHH	31.35	25266776
231	Glutathionylation	SPREETACHSSLPEK CCCCCCCCCCCCCCC	4.11	24333276
242	Acetylation	LPEKPPMKPFILTRN CCCCCCCCCEEEECC	42.42	-
260	Phosphorylation	AKVFGTGYPSLATMT HHHHCCCCCCHHEEE	6.89	29514104
278	Phosphorylation	WYEQHQKYGVLPDRG HHHHHHHHCCCCCCC	13.09	29514104
291	Phosphorylation	RGIAKPASADFQRAA CCCCCCCCHHHHHHH	36.58	30352176
333	Phosphorylation	KDTHPRGYGNRQNMG CCCCCCCCCCCCCCC	16.71	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IGBP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IGBP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IGBP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PP2AA_MOUSE	Ppp2ca	physical	11371618
TRI18_MOUSE	Mid1	physical	11371618
TRI18_HUMAN	MID1	physical	11806752
TRIM1_HUMAN	MID2	physical	11806752
PP2AB_MOUSE	Ppp2cb	physical	10491115
PP2AB_MOUSE	Ppp2cb	physical	21454489
TRI18_MOUSE	Mid1	physical	21454489

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.