TRI18_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRI18_MOUSE
• UniProt AC: O70583
• Protein Name: E3 ubiquitin-protein ligase Midline-1
• Gene Name: Mid1
• Organism: Mus musculus (Mouse).
• Sequence Length: 680
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton . Microtubule-associated.
• Protein Description: Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination..
• Protein Sequence: METLESELTCPICLELFEDPLLLPCAHSLCFNCAHRILVSHCATNEPVESINAFQCPTCRHVITLSQRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSETRRERAFDANTMSSAEKVLCQFCDQDPAQDAVKTCVTCEVSYCDECLKATHPNKKPFTGHRLIEPIPDSHIRGLMCLEHEDEKVNMYCVTDDQLICALCKLVGRHRDHQVAALSERYDKLKQNLESNLTNLIKRNTELETLLAKLIQTCQHVEVNASRQEAKLTEECDLLIEIIQQRRQIIGTKIKEGKVIRLRKLAQQIANCKQCLERSASLISQAEHSLKENDHARFLQTAKNITERVSMATASSQVLIPEINLNDTFDTFALDFSREKKLLECLDYLTAPNPPAIREELCTASYDTITVHWTSEDEFSVVSYELQYTIFTGQANVVNVACDGTCLLGSAGLCNSADSWMIVPNIKQNHYTVHGLQSGTKYIFTVKAINQAGSRSSEPGKLKTNSQPFRLDPKSAHRKLKVSHDNLTVERDESSSKKSHAPERFAGQGSYGVAGNVFIDSGRHYWEVVTSGSTWYAIGLAYRSAPKHEWIGKNAASWALCRCHNHWAVRHDGKETPIAPAPHLRRVGVLLDYDNGSIAFYDALSSVHLHTFHAALAQPVCPTFTVWNKCLTIVTGLPIPDHLDCTEQRP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	Phosphorylation	DGLKRNVTLQNIIDR HHHHHCCCHHHHHHH	26.61	22817900
90	Phosphorylation	IDRFQKASVSGPNSP HHHHHHHCCCCCCCC	24.69	21743459
92	Phosphorylation	RFQKASVSGPNSPSE HHHHHCCCCCCCCCH	46.14	27087446
96	Phosphorylation	ASVSGPNSPSETRRE HCCCCCCCCCHHHHH	32.70	27087446
98	Phosphorylation	VSGPNSPSETRRERA CCCCCCCCHHHHHHH	51.96	24899341
100	Phosphorylation	GPNSPSETRRERAFD CCCCCCHHHHHHHCC	39.09	27087446
133	Phosphorylation	PAQDAVKTCVTCEVS HHHHHHHHHEEEEEE	12.95	-
136	Phosphorylation	DAVKTCVTCEVSYCD HHHHHHEEEEEEECH	12.70	-
140	Phosphorylation	TCVTCEVSYCDECLK HHEEEEEEECHHHHH	9.57	-
141	Phosphorylation	CVTCEVSYCDECLKA HEEEEEEECHHHHHH	14.75	-
311	Phosphorylation	QCLERSASLISQAEH HHHHHHHHHHHHHHH	27.73	26370283
314	Phosphorylation	ERSASLISQAEHSLK HHHHHHHHHHHHHHC	28.73	26370283
513	Phosphorylation	AHRKLKVSHDNLTVE HCCCCCCCCCCCEEE	24.44	22817900
524	Phosphorylation	LTVERDESSSKKSHA CEEECCCCCCCCCCC	44.17	25338131
525	Phosphorylation	TVERDESSSKKSHAP EEECCCCCCCCCCCC	44.09	25338131
526	Phosphorylation	VERDESSSKKSHAPE EECCCCCCCCCCCCH	54.07	25338131
540	Phosphorylation	ERFAGQGSYGVAGNV HHHCCCCCCCEEEEE	15.72	-
541	Phosphorylation	RFAGQGSYGVAGNVF HHCCCCCCCEEEEEE	23.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRI18_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRI18_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRI18_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IGBP1_MOUSE	Igbp1	physical	11371618
M1IP1_MOUSE	Mid1ip1	physical	15070402

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.