dbPTM

HTRA4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HTRA4_HUMAN
UniProt AC	P83105
Protein Name	Serine protease HTRA4
Gene Name	HTRA4
Organism	Homo sapiens (Human).
Sequence Length	476
Subcellular Localization	Secreted.
Protein Description	Serine protease..
Protein Sequence	MIRPQLRTAGLGRCLLPGLLLLLVPVLWAGAEKLHTQPSCPAVCQPTRCPALPTCALGTTPVFDLCRCCRVCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPSTCGCPTLGGAVCGSDRRTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLRRNYNFIAAVVEKVAPSVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNGARYEAVVKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAGIVSTKQRGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVRQFLAEYHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDSLSMAVLRGKDNLLLTVIPETIN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
310	Phosphorylation	KELGMKDSDMDYVQI EECCCCCCCCCEEEE	29.35	-
314	Phosphorylation	MKDSDMDYVQIDATI CCCCCCCEEEEEEEE	6.39	-
424	Phosphorylation	EGTAAQSSGLRDHDV ECCCCCCCCCCCCEE	29.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HTRA4_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HTRA4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HTRA4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OTUD4_HUMAN	OTUD4	physical	28514442
TTC28_HUMAN	TTC28	physical	28514442
ZC3H4_HUMAN	ZC3H4	physical	28514442
CPSF4_HUMAN	CPSF4	physical	28514442
RBPMS_HUMAN	RBPMS	physical	28514442
WDCP_HUMAN	C2orf44	physical	28514442
RBMS1_HUMAN	RBMS1	physical	28514442
WDR26_HUMAN	WDR26	physical	28514442
IF4E2_HUMAN	EIF4E2	physical	28514442

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HTRA4_HUMAN

Related Literatures of Post-Translational Modification