| UniProt ID | HEM4_HUMAN | |
|---|---|---|
| UniProt AC | P10746 | |
| Protein Name | Uroporphyrinogen-III synthase | |
| Gene Name | UROS | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 265 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).. | |
| Protein Sequence | MKVLLLKDAKEDDCGQDPYIRELGLYGLEATLIPVLSFEFLSLPSFSEKLSHPEDYGGLIFTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLDTEGETCGNAEKLAEYICSRESSALPLLFPCGNLKREILPKALKDKGIAMESITVYQTVAHPGIQGNLNSYYSQQGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTARALAAQGLPVSCTAESPTPQALATGIRKALQPHGCC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Acetylation | -MKVLLLKDAKEDDC -CCEEEECCCCCCCC | 56.46 | 23749302 | |
| 10 | Acetylation | VLLLKDAKEDDCGQD EEEECCCCCCCCCCC | 72.34 | 23749302 | |
| 10 | Malonylation | VLLLKDAKEDDCGQD EEEECCCCCCCCCCC | 72.34 | 26320211 | |
| 19 | Phosphorylation | DDCGQDPYIRELGLY CCCCCCHHHHHHHCC | 22.39 | - | |
| 124 | Ubiquitination | ETCGNAEKLAEYICS CCCCCHHHHHHHHHC | 51.06 | - | |
| 124 | Acetylation | ETCGNAEKLAEYICS CCCCCHHHHHHHHHC | 51.06 | 25953088 | |
| 204 | Phosphorylation | SPSGLTYSLKHIQEL CCCCCCEEHHHHHHH | 26.21 | 24719451 | |
| 220 | Ubiquitination | GDNIDQIKFAAIGPT CCCCCEEEEEEECHH | 24.26 | - | |
| 227 | Phosphorylation | KFAAIGPTTARALAA EEEEECHHHHHHHHH | 28.07 | - | |
| 240 | Phosphorylation | AAQGLPVSCTAESPT HHCCCCCEEECCCCC | 12.10 | 25850435 | |
| 242 | Phosphorylation | QGLPVSCTAESPTPQ CCCCCEEECCCCCHH | 26.42 | 25850435 | |
| 245 | Phosphorylation | PVSCTAESPTPQALA CCEEECCCCCHHHHH | 31.45 | 25850435 | |
| 247 | Phosphorylation | SCTAESPTPQALATG EEECCCCCHHHHHHH | 36.99 | 25850435 | |
| 253 | Phosphorylation | PTPQALATGIRKALQ CCHHHHHHHHHHHHC | 33.71 | 27080861 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HEM4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HEM4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HEM4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| MOCS1_HUMAN | MOCS1 | physical | 26186194 | |
| TCAL1_HUMAN | TCEAL1 | physical | 26186194 | |
| GSH0_HUMAN | GCLM | physical | 26186194 | |
| CTU2_HUMAN | CTU2 | physical | 26186194 | |
| EED_HUMAN | EED | physical | 26186194 | |
| CTU1_HUMAN | CTU1 | physical | 26186194 | |
| ATG7_HUMAN | ATG7 | physical | 26186194 | |
| BOLA1_HUMAN | BOLA1 | physical | 26186194 | |
| MOCS1_HUMAN | MOCS1 | physical | 28514442 | |
| BOLA1_HUMAN | BOLA1 | physical | 28514442 | |
| GSH0_HUMAN | GCLM | physical | 28514442 | |
| TCAL1_HUMAN | TCEAL1 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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