| UniProt ID | HEM2_HUMAN | |
|---|---|---|
| UniProt AC | P13716 | |
| Protein Name | Delta-aminolevulinic acid dehydratase | |
| Gene Name | ALAD | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 330 | |
| Subcellular Localization | ||
| Protein Description | Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.. | |
| Protein Sequence | MQPQSVLHSGYFHPLLRAWQTATTTLNASNLIYPIFVTDVPDDIQPITSLPGVARYGVKRLEEMLRPLVEEGLRCVLIFGVPSRVPKDERGSAADSEESPAIEAIHLLRKTFPNLLVACDVCLCPYTSHGHCGLLSENGAFRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRDAAKSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSGEFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKEE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 (in isoform 2) | Phosphorylation | - | 4.73 | - | |
| 168 | Phosphorylation | GCQVVAPSDMMDGRV CCEEECCHHHCCCHH | 28.53 | 46161819 | |
| 170 | Sulfoxidation | QVVAPSDMMDGRVEA EEECCHHHCCCHHHH | 2.86 | 30846556 | |
| 171 | Sulfoxidation | VVAPSDMMDGRVEAI EECCHHHCCCHHHHH | 6.24 | 30846556 | |
| 179 | Ubiquitination | DGRVEAIKEALMAHG CCHHHHHHHHHHHCC | 43.94 | - | |
| 183 | Sulfoxidation | EAIKEALMAHGLGNR HHHHHHHHHCCCCCC | 3.14 | 30846556 | |
| 192 | Phosphorylation | HGLGNRVSVMSYSAK CCCCCCEEEEEEEHH | 14.63 | 20068231 | |
| 199 | Succinylation | SVMSYSAKFASCFYG EEEEEEHHHHHHHHC | 35.21 | - | |
| 199 | Succinylation | SVMSYSAKFASCFYG EEEEEEHHHHHHHHC | 35.21 | - | |
| 205 | Phosphorylation | AKFASCFYGPFRDAA HHHHHHHHCCCHHHH | 28.37 | 46161825 | |
| 213 | Ubiquitination | GPFRDAAKSSPAFGD CCCHHHHHCCCCCCC | 53.86 | - | |
| 214 | Phosphorylation | PFRDAAKSSPAFGDR CCHHHHHCCCCCCCC | 36.51 | 23401153 | |
| 215 | Phosphorylation | FRDAAKSSPAFGDRR CHHHHHCCCCCCCCC | 21.38 | 24972180 | |
| 242 (in isoform 2) | Ubiquitination | - | 6.64 | - | |
| 252 | Succinylation | GADMLMVKPGMPYLD CCCEEEECCCCCHHH | 23.14 | - | |
| 252 | Ubiquitination | GADMLMVKPGMPYLD CCCEEEECCCCCHHH | 23.14 | - | |
| 252 | Succinylation | GADMLMVKPGMPYLD CCCEEEECCCCCHHH | 23.14 | - | |
| 281 (in isoform 2) | Ubiquitination | - | 23.79 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HEM2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HEM2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HEM2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| AGFG1_HUMAN | AGFG1 | physical | 22863883 | |
| GON7_HUMAN | C14orf142 | physical | 22863883 | |
| GPN1_HUMAN | GPN1 | physical | 22863883 | |
| HPBP1_HUMAN | HSPBP1 | physical | 22863883 | |
| OGT1_HUMAN | OGT | physical | 22863883 | |
| PPME1_HUMAN | PPME1 | physical | 22863883 | |
| RPR1B_HUMAN | RPRD1B | physical | 22863883 | |
| SURF2_HUMAN | SURF2 | physical | 22863883 | |
| TM1L1_HUMAN | TOM1L1 | physical | 22863883 | |
| WDR4_HUMAN | WDR4 | physical | 22863883 | |
| ZPR1_HUMAN | ZPR1 | physical | 22863883 | |
| STA5B_HUMAN | STAT5B | physical | 26344197 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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