GRAP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRAP2_MOUSE
• UniProt AC: O89100
• Protein Name: GRB2-related adaptor protein 2
• Gene Name: Grap2
• Organism: Mus musculus (Mouse).
• Sequence Length: 322
• Subcellular Localization: Nucleus. Cytoplasm. Endosome.
• Protein Description: Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc..
• Protein Sequence: MEATAKFDFMASGEDELSFRTGDILKILSNQEEWLKAELGSQEGYVPKNFIDIEFPEWFHEGLSRHQAENLLMGKDIGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDTKGNYFLWTEKFPSLNKLVDYYRTTSISKQKQVFLRDGTQDQGHRGNSLDRRSQGGPHPSGTVGEEIRPSVNRKLSDHLPLGPQQFHPHQQPSPQFTPGPQPPQQQRYLQHFHQDRRGGSLDINDGHCGLGSEVNATLMHRRHTDPVQLQAAGRVRWARALYDFEALEEDELGFRSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMMR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	WLKAELGSQEGYVPK HHHHHHCCCCCCCCC	37.37	28833060
45	Phosphorylation	ELGSQEGYVPKNFID HHCCCCCCCCCCEEC	16.90	27566939
85	Phosphorylation	GFFIIRASQSSPGDF EEEEEEECCCCCCCE	22.27	28833060
87	Phosphorylation	FIIRASQSSPGDFSI EEEEECCCCCCCEEE	35.68	27566939
88	Phosphorylation	IIRASQSSPGDFSIS EEEECCCCCCCEEEE	25.84	28833060
93	Phosphorylation	QSSPGDFSISVRHED CCCCCCEEEEEECCC	20.77	27566939
106	Acetylation	EDDVQHFKVMRDTKG CCCCCEEEEEECCCC	32.75	-
158	Phosphorylation	DQGHRGNSLDRRSQG CCCCCCCCCCCHHCC	34.18	29899451
163	Phosphorylation	GNSLDRRSQGGPHPS CCCCCCHHCCCCCCC	33.79	25266776
170	Phosphorylation	SQGGPHPSGTVGEEI HCCCCCCCCCCCCCC	44.02	25266776
172	Phosphorylation	GGPHPSGTVGEEIRP CCCCCCCCCCCCCCH	29.67	25266776
180	Phosphorylation	VGEEIRPSVNRKLSD CCCCCCHHHCHHHHC	23.36	25266776
186	Phosphorylation	PSVNRKLSDHLPLGP HHHCHHHHCCCCCCC	26.48	25266776
203	Phosphorylation	FHPHQQPSPQFTPGP CCCCCCCCCCCCCCC	27.31	25266776
207	Phosphorylation	QQPSPQFTPGPQPPQ CCCCCCCCCCCCCHH	23.30	25266776
230	Phosphorylation	HQDRRGGSLDINDGH HHCCCCCCCCCCCCC	26.20	25266776
242	Phosphorylation	DGHCGLGSEVNATLM CCCCCCCHHHHHHHC	43.33	25266776
247	Phosphorylation	LGSEVNATLMHRRHT CCHHHHHHHCCCCCC	21.29	25266776
254	Phosphorylation	TLMHRRHTDPVQLQA HHCCCCCCCCHHHHH	39.94	27742792

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
254	T	Phosphorylation	Kinase	HPK1	Q92918	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRAP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRAP2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EGFR_HUMAN	EGFR	physical	9872323
SHC1_HUMAN	SHC1	physical	9872323
ABL1_HUMAN	ABL1	physical	9872323
KHDR1_HUMAN	KHDRBS1	physical	9872323
CBL_HUMAN	CBL	physical	9872323
SOS1_HUMAN	SOS1	physical	9872323
KIT_MOUSE	Kit	physical	9872323
M4K1_MOUSE	Map4k1	physical	15100220
SHC1_MOUSE	Shc1	physical	9872323

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.