GMFG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GMFG_HUMAN
• UniProt AC: O60234
• Protein Name: Glia maturation factor gamma
• Gene Name: GMFG
• Organism: Homo sapiens (Human).
• Sequence Length: 142
• Protein Sequence: MSDSLVVCEVDPELTEKLRKFRFRKETDNAAIIMKVDKDRQMVVLEEEFQNISPEELKMELPERQPRFVVYSYKYVHDDGRVSYPLCFIFSSPVGCKPEQQMMYAGSKNRLVQTAELTKVFEIRTTDDLTEAWLQEKLSFFR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDSLVVCE ------CCCCEEEEE	35.59	16873721
2	Acetylation	------MSDSLVVCE ------CCCCEEEEE	35.59	25944712
4	Phosphorylation	----MSDSLVVCEVD ----CCCCEEEEECC	18.76	16873721
17	Ubiquitination	VDPELTEKLRKFRFR CCHHHHHHHHHHHCC	48.64	-
20	Ubiquitination	ELTEKLRKFRFRKET HHHHHHHHHHCCCCC	51.86	-
25	Ubiquitination	LRKFRFRKETDNAAI HHHHHCCCCCCCEEE	63.35	-
27	Phosphorylation	KFRFRKETDNAAIIM HHHCCCCCCCEEEEE	37.27	23882029
34	Sulfoxidation	TDNAAIIMKVDKDRQ CCCEEEEEEECCCCC	2.57	21406390
35	Acetylation	DNAAIIMKVDKDRQM CCEEEEEEECCCCCE	36.55	25953088
35	Ubiquitination	DNAAIIMKVDKDRQM CCEEEEEEECCCCCE	36.55	19608861
38	Ubiquitination	AIIMKVDKDRQMVVL EEEEEECCCCCEEEE	58.77	-
42	Sulfoxidation	KVDKDRQMVVLEEEF EECCCCCEEEEHHHH	2.04	21406390
74	Acetylation	RFVVYSYKYVHDDGR CEEEEEEEEECCCCC	34.55	25953088
74	Ubiquitination	RFVVYSYKYVHDDGR CEEEEEEEEECCCCC	34.55	-
83	Phosphorylation	VHDDGRVSYPLCFIF ECCCCCEECEEEEEE	21.48	-
84	Phosphorylation	HDDGRVSYPLCFIFS CCCCCEECEEEEEEC	9.43	19060867
97	Ubiquitination	FSSPVGCKPEQQMMY ECCCCCCCHHHHHCC	45.73	-
104	Phosphorylation	KPEQQMMYAGSKNRL CHHHHHCCCCCCCCE	11.50	-
108	Ubiquitination	QMMYAGSKNRLVQTA HHCCCCCCCCEEEEE	45.21	-
119	Ubiquitination	VQTAELTKVFEIRTT EEEEHHEEEEEEECC	58.51	21890473
119	Ubiquitination	VQTAELTKVFEIRTT EEEEHHEEEEEEECC	58.51	21890473
119	Acetylation	VQTAELTKVFEIRTT EEEEHHEEEEEEECC	58.51	19608861
125	Phosphorylation	TKVFEIRTTDDLTEA EEEEEEECCCCCHHH	39.99	27251275
126	Phosphorylation	KVFEIRTTDDLTEAW EEEEEECCCCCHHHH	20.05	27251275
137	Ubiquitination	TEAWLQEKLSFFR-- HHHHHHHHHHCCC--	36.15	21890473
139	Phosphorylation	AWLQEKLSFFR---- HHHHHHHHCCC----	33.15	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
104	Y	Phosphorylation	Kinase	ABL	P00519	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GMFG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GMFG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VANG1_HUMAN	VANGL1	physical	21988832
PRUN1_HUMAN	PRUNE	physical	28514442
LANC2_HUMAN	LANCL2	physical	28514442
HSP7E_HUMAN	HSPA14	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-119, AND MASS SPECTROMETRY.
PubMed: 19608861