dbPTM

GLRB_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GLRB_RAT
UniProt AC	P20781
Protein Name	Glycine receptor subunit beta
Gene Name	Glrb
Organism	Rattus norvegicus (Rat).
Sequence Length	496
Subcellular Localization	Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein . Cell membrane Multi-pass membrane protein . Cell junction, synapse . Perikaryon . Cell projection, dendrite . Cytoplasm . Retained in the cytoplasm upon heterologous
Protein Description	Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. [PubMed: 15574743]
Protein Sequence	MKFSLAVSFFILMSLLFEDACSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPPNSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNAAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKPQAKNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	N-linked_Glycosylation	DLARVPPNSTSNILN HHHCCCCCCHHHHHH	52.42	-
242	N-linked_Glycosylation	KEDIEYGNCTKYYKG HHHCCCCCCCEEECC	29.41	-
391	Phosphorylation	NTVNGTGTPVHISTL CCCCCCCCEEEEEEE	23.21	30240740
425	Phosphorylation	NDFSIVGSLPRDFEL CCCEEECCCCCCEEC	25.06	30240740

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GLRB_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GLRB_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GLRB_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GEPH_RAT	Gphn	physical	12967995
PROF1_RAT	Pfn1	physical	12967995
GEPH_MOUSE	Gphn	physical	12967995
PROF1_MOUSE	Pfn1	physical	12967995
GEPH_RAT	Gphn	physical	16449194
DC1I1_RAT	Dync1i1	physical	16449194
DYHC1_RAT	Dync1h1	physical	16449194

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GLRB_RAT

Related Literatures of Post-Translational Modification