DC1I1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DC1I1_RAT
• UniProt AC: Q63100
• Protein Name: Cytoplasmic dynein 1 intermediate chain 1
• Gene Name: Dync1i1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 643
• Subcellular Localization: Cytoplasm . Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole.
• Protein Description: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores..
• Protein Sequence: MSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVPDDSDLDRKRRETEALLQSIGISPEPPLVQPLHFLTWDTCYFHYLVPTPMSPSSKSVSTPSEAGSQDDLGPLTRTLQWDTDPSVLQLQSDSELGRRLNKLGVSKVTQVDFLPREVVSYSKETQTPLATHQSEEDEEDEEMVEPKVGHDSELENQDKKQETKEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYSNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNSDTEVPTASVAIEGAYALNRVRWAQGGKEVAVGDSEGRIWIYDVGELAVPHNDEWTRFARTLVEIRANRADSEEEGAVELAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSDKSDLKA ------CCCHHHHHH	54.46	-
50	Phosphorylation	KEPVPDDSDLDRKRR CCCCCCCHHHHHHHH	47.67	-
100	Phosphorylation	PTPMSPSSKSVSTPS CCCCCCCCCCCCCCC	32.13	11340075
102	Phosphorylation	PMSPSSKSVSTPSEA CCCCCCCCCCCCCCC	24.21	28551015
104	Phosphorylation	SPSSKSVSTPSEAGS CCCCCCCCCCCCCCC	41.51	25403869
105	Phosphorylation	PSSKSVSTPSEAGSQ CCCCCCCCCCCCCCC	28.78	25403869
107	Phosphorylation	SKSVSTPSEAGSQDD CCCCCCCCCCCCCCC	39.92	28432305
111	Phosphorylation	STPSEAGSQDDLGPL CCCCCCCCCCCCCCC	37.17	30240740
119	Phosphorylation	QDDLGPLTRTLQWDT CCCCCCCCCEEECCC	25.41	28551015
150	Ubiquitination	LNKLGVSKVTQVDFL HHHHCCCCCEEEEEC	47.06	-
168	Phosphorylation	VVSYSKETQTPLATH HHCCCCCCCCCCCCC	41.29	28551015
170	Phosphorylation	SYSKETQTPLATHQS CCCCCCCCCCCCCCC	27.91	30240740
174	Phosphorylation	ETQTPLATHQSEEDE CCCCCCCCCCCCCCC	28.29	22108457
177	Phosphorylation	TPLATHQSEEDEEDE CCCCCCCCCCCCCCH	35.04	30411139
195	Phosphorylation	EPKVGHDSELENQDK CCCCCCHHHHCCHHH	38.11	30240740
284	Acetylation	FYDEHWSKHRVVTCM HCHHCHHCCEEEEEH	30.18	22902405
633	Phosphorylation	IRANRADSEEEGAVE HHHHCCCCCCCCCEE	46.02	30240740

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DC1I1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DC1I1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DC1I1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCTN1_RAT	Dctn1	physical	21911489
DCTN2_RAT	Dctn2	physical	21911489

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.