DCTN2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCTN2_RAT
• UniProt AC: Q6AYH5
• Protein Name: Dynactin subunit 2
• Gene Name: Dctn2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 402
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Peripheral membrane protein.
• Protein Description: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity)..
• Protein Sequence: MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELSSTSVEHIIVNPNAAYDKFKDKRVGTKGLDFSDRIGKTKRTGYESGDYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKTTVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLADPDGALAKRLLLQLEATKSSKGSSGGKSTGGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAGLQGACLMETVELLQAKVNALDLAVLDQVEARLQSVLGKVNEIAKHKASVEDADTQNKVHQLYETIQRWSPVASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMMASSLKDNTALLTQVQTTMRENLATVEGNFASIDARMKKLGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADPKYADL ------CCCCCCCCC	41.64	-
5	Ubiquitination	---MADPKYADLPGI ---CCCCCCCCCCCC	54.33	-
6	Phosphorylation	--MADPKYADLPGIA --CCCCCCCCCCCCC	15.67	22276854
79	Phosphorylation	RIGKTKRTGYESGDY HCCCCCCCCCCCCCC	45.75	28689409
81	Phosphorylation	GKTKRTGYESGDYEM CCCCCCCCCCCCCHH	13.30	28689409
83	Phosphorylation	TKRTGYESGDYEMLG CCCCCCCCCCCHHCC	28.60	28432305
86	Phosphorylation	TGYESGDYEMLGEGL CCCCCCCCHHCCCCC	13.53	30181290
127	Phosphorylation	IKTTVKESATEEKLT HHHHHHHHCCCCCCH	34.47	28432305
129	Phosphorylation	TTVKESATEEKLTPV HHHHHHCCCCCCHHH	54.69	28432305
134	Phosphorylation	SATEEKLTPVVLAKQ HCCCCCCHHHHHHHH	25.71	-
146	Acetylation	AKQLAALKQQLVASH HHHHHHHHHHHHHHH	31.13	22902405
195	Phosphorylation	KGSSGGKSTGGTPPD CCCCCCCCCCCCCCC	35.24	27097102
196	Phosphorylation	GSSGGKSTGGTPPDS CCCCCCCCCCCCCCC	43.02	27097102
199	Phosphorylation	GGKSTGGTPPDSSLV CCCCCCCCCCCCCCE	32.75	29779826
203	Phosphorylation	TGGTPPDSSLVTYEL CCCCCCCCCCEEEEE	31.20	27097102
204	Phosphorylation	GGTPPDSSLVTYELH CCCCCCCCCEEEEEC	33.95	27097102
207	Phosphorylation	PPDSSLVTYELHSRP CCCCCCEEEEECCCC	19.30	28551015
208	Phosphorylation	PDSSLVTYELHSRPE CCCCCEEEEECCCCC	14.71	28551015
212	Phosphorylation	LVTYELHSRPEQDKF CEEEEECCCCCCCHH	63.25	28551015
309	Acetylation	EDADTQNKVHQLYET HCHHHHHHHHHHHHH	31.14	22902405
321	Phosphorylation	YETIQRWSPVASTLP HHHHHHHCCHHHHHH	16.22	22673903
325	Phosphorylation	QRWSPVASTLPELVQ HHHCCHHHHHHHHHH	30.61	22673903
326	Phosphorylation	RWSPVASTLPELVQR HHCCHHHHHHHHHHH	36.27	22673903
385	Phosphorylation	TMRENLATVEGNFAS HHHHHHHHHCCCCHH	23.43	25575281
392	Phosphorylation	TVEGNFASIDARMKK HHCCCCHHHHHHHHH	19.50	25575281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCTN2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCTN2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCTN2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of DCTN2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.