FZD4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FZD4_HUMAN
• UniProt AC: Q9ULV1
• Protein Name: Frizzled-4
• Gene Name: FZD4
• Organism: Homo sapiens (Human).
• Sequence Length: 537
• Subcellular Localization: Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues..
• Protein Sequence: MAWRGAGPSVPGAPGGVGLSLGLLLQLLLLLGPARGFGDEEERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEFGFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGSETVV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	N-linked_Glycosylation	MCQNLGYNVTKMPNL HCCCCCCCCCCCCCC	32.93	UniProtKB CARBOHYD
144	N-linked_Glycosylation	FAWPESLNCSKFPPQ CCCCCCCCCCCCCCC	36.98	UniProtKB CARBOHYD
212	Phosphorylation	GYDAGLYSRSAKEFT CCCCCCCCCCHHHHH	25.46	24719451
422	Ubiquitination	KIRSNLQKDGTKTDK HHHHHHCCCCCCCHH	62.38	24816145
516	Acetylation	NRLVNSGKVKREKRG HHHHHCCCCCEEECC	44.39	7668849
518	Acetylation	LVNSGKVKREKRGNG HHHCCCCCEEECCCC	59.32	7668859
521	Acetylation	SGKVKREKRGNGWVK CCCCCEEECCCCCCC	70.42	7668869

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FZD4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FZD4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FZD4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BAG6_HUMAN	BAG6	physical	21900206
ZNRF3_HUMAN	ZNRF3	physical	22575959
NDP_HUMAN	NDP	physical	15035989
NDP_HUMAN	NDP	physical	17955262
DVL3_MOUSE	Dvl3	physical	25198863
PZRN3_HUMAN	PDZRN3	physical	25198863
RAB5A_HUMAN	RAB5A	physical	25198863

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.