EFC4A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFC4A_HUMAN
• UniProt AC: Q8N4Y2
• Protein Name: EF-hand calcium-binding domain-containing protein 4A
• Gene Name: CRACR2B
• Organism: Homo sapiens (Human).
• Sequence Length: 399
• Protein Description: Plays a role in store-operated Ca(2+) entry (SOCE)..
• Protein Sequence: MASPGKPGADEAQEEEGELEGGSAGPRAAILEQAEELFLLCDKEAKGFITKHDLQGLQSDLPLTPEQLEAVFESLDRAHTGFLTAREFCLGLGMFVGVASAQGANPCRTPEETFESGGLDVQGTAGSLDEEEEEEERFHTVLEQLGVAPVLGKQRAVRTLWARLQRERPELLGSFEDVLIRASACLEEAARERDGLEQALRRRESEHEREVRALYEETEQLREQSRRPPSQNFARGERRSRLELELQSREQDLERAGLRQRELEQQLHAQAAEHLEAQAQNSQLWRAHEALRTQLEGAQEQIRRLESEARGRQEQTQRDVVAVSRNMQKEKVSLLRQLELLRELNTRLRDDRDACEARRAGSSCRKALTTARLPGPTCCCCCCWARPPRRGSGHLPSAR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASPGKPGAD -----CCCCCCCCCH	32.65	25159151
3 (in isoform 3)	Phosphorylation	-	32.65	24719451
174	Phosphorylation	ERPELLGSFEDVLIR HCHHHHCCHHHHHHH	25.98	29802988
174 (in isoform 3)	Phosphorylation	-	25.98	24719451
215 (in isoform 3)	Phosphorylation	-	15.67	27642862
230	Phosphorylation	EQSRRPPSQNFARGE HHHCCCCCCCCCCCH	40.20	24719451
230 (in isoform 3)	Phosphorylation	-	40.20	24719451
240	Phosphorylation	FARGERRSRLELELQ CCCCHHHHHHHHHHH	47.65	27251275
240 (in isoform 3)	Phosphorylation	-	47.65	27251275
282 (in isoform 3)	Phosphorylation	-	17.99	-
324	Phosphorylation	QRDVVAVSRNMQKEK HHHHHHHCCCCHHHH	14.27	24719451
370	Phosphorylation	SCRKALTTARLPGPT HHHHHHHHCCCCCCE	15.61	24719451
377	Phosphorylation	TARLPGPTCCCCCCW HCCCCCCEEEECCCC	24.88	28387310
392	Phosphorylation	ARPPRRGSGHLPSAR CCCCCCCCCCCCCCC	22.64	22985185
397	Phosphorylation	RGSGHLPSAR----- CCCCCCCCCC-----	42.93	24670416

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFC4A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFC4A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFC4A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
GHITM_HUMAN	GHITM	physical	26186194
CAR19_HUMAN	C9orf89	physical	26186194
CAR19_HUMAN	C9orf89	physical	28514442
TIM29_HUMAN	C19orf52	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.