| UniProt ID | E2FC_ARATH | |
|---|---|---|
| UniProt AC | Q9FV70 | |
| Protein Name | Transcription factor E2FC | |
| Gene Name | E2FC | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 396 | |
| Subcellular Localization | Cytoplasm . Interaction with either DPA or DPB are unable to induce a nuclear localization. | |
| Protein Description | Involved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex.. | |
| Protein Sequence | MAATSNSGEDPTLSYHHRSPFRFELLQSISSSDPRYSSLTPSSTNRPFSVSQSLPNSQLSPLISPHWDDSYSQITQKVQKSRKNHRIQLGSIANMSGGESIDIAKVIVKQESSPQNVKRVYNKSKGGTKLLKAGKRMANGEVQNGGLNGASINCRYDSSLGLLTKKFVKLIQEAEDGTLDLNYCAVVLEVQKRRIYDITNVLEGIGLIEKTTKNHIRWKGADNLGQKDLGDQISRLKSEVESMQSEESRLDDLIRERQEALRSLEEDDYCRRYMFMTEEDITSLPRFQNQTLLAIKAPTASYIEVPDPDEMSFPQQYRMVIRSRMGPIDVYLLSKYKGDSAETSDKLGNESDQKAPVGVDTPSLKIVTSDTDLKADYWFESDAEVSLTDLWSNFNS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 156 | Phosphorylation | GASINCRYDSSLGLL CCEEECCCCCCHHHH | 23.52 | 23328941 | |
| 368 | Phosphorylation | TPSLKIVTSDTDLKA CCCEEEECCCCCCCC | 25.10 | 25561503 | |
| 369 | Phosphorylation | PSLKIVTSDTDLKAD CCEEEECCCCCCCCC | 27.84 | 25561503 | |
| 371 | Phosphorylation | LKIVTSDTDLKADYW EEEECCCCCCCCCEE | 42.89 | 25561503 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of E2FC_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of E2FC_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of E2FC_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CDKA1_ARATH | CDC2 | physical | 12468727 | |
| CCA22_ARATH | CYC3B | physical | 12468727 | |
| CCD21_ARATH | CYCD2;1 | physical | 12468727 | |
| SKP2B_ARATH | SKP2B | physical | 12468727 | |
| CUL1_ARATH | CUL1 | physical | 12468727 | |
| DPB_ARATH | DPB | physical | 16920782 | |
| DPB_ARATH | DPB | physical | 20407024 | |
| DPA_ARATH | DPA | physical | 20407024 | |
| RBR1_ARATH | RBR1 | physical | 20706207 | |
| DCE1_ARATH | GAD | physical | 20706207 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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