| UniProt ID | DRD2_MOUSE | |
|---|---|---|
| UniProt AC | P61168 | |
| Protein Name | D(2) dopamine receptor | |
| Gene Name | Drd2 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 444 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.. | |
| Protein Sequence | MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | N-linked_Glycosylation | ---MDPLNLSWYDDD ---CCCCCCCCCCHH | 37.10 | - | |
| 17 | N-linked_Glycosylation | DDDLERQNWSRPFNG CHHHHHCCCCCCCCC | 44.93 | - | |
| 23 | N-linked_Glycosylation | QNWSRPFNGSEGKPD CCCCCCCCCCCCCCC | 56.62 | - | |
| 133 | Phosphorylation | CAISIDRYTAVAMPM HCCCCCHHHHHHHHH | 8.70 | 28285833 | |
| 134 | Phosphorylation | AISIDRYTAVAMPML CCCCCHHHHHHHHHH | 18.62 | 28285833 | |
| 237 | Ubiquitination | RAFRANLKTPLKGNC HHHHHHCCCCCCCCC | 48.15 | 27667366 | |
| 286 | Phosphorylation | LEMEMLSSTSPPERT HHHHHHHCCCCCCCC | 29.01 | 29899451 | |
| 288 | Phosphorylation | MEMLSSTSPPERTRY HHHHHCCCCCCCCCC | 40.17 | 29899451 | |
| 444 | S-palmitoylation | AFMKILHC------- HHHHHHCC------- | 5.52 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DRD2_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DRD2_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DRD2_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| PAWR_MOUSE | Pawr | physical | 16051151 | |
| SH3K1_MOUSE | Sh3kbp1 | physical | 20551902 | |
| SH3G2_MOUSE | Sh3gl2 | physical | 20551902 | |
| DYN1_MOUSE | Dnm1 | physical | 20551902 | |
| DLG4_MOUSE | Dlg4 | physical | 20551902 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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