DHX32_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHX32_HUMAN
• UniProt AC: Q7L7V1
• Protein Name: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32
• Gene Name: DHX32
• Organism: Homo sapiens (Human).
• Sequence Length: 743
• Subcellular Localization: Nucleus . Mitochondrion .
• Protein Sequence: MEEEGLECPNSSSEKRYFPESLDSSDGDEEEVLACEDLELNPFDGLPYSSRYYKLLKEREDLPIWKEKYSFMENLLQNQIVIVSGDAKCGKSAQVPQWCAEYCLSIHYQHGGVICTQVHKQTVVQLALRVADEMDVNIGHEVGYVIPFENCCTNETILRYCTDDMLQREMMSNPFLGSYGVIILDDIHERSIATDVLLGLLKDVLLARPELKLIINSSPHLISKLNSYYGNVPVIEVKNKHPVEVVYLSEAQKDSFESILRLIFEIHHSGEKGDIVVFLACEQDIEKVCETVYQGSNLNPDLGELVVVPLYPKEKCSLFKPLDETEKRCQVYQRRVVLTTSSGEFLIWSNSVRFVIDVGVERRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTEEFASKDMTPLKPAEMQEANLTSMVLFMKRIDIAGLGHCDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEVLTIAAMVTAPNCFSHVPHGAEEAALTCWKTFLHPEGDHFTLISIYKAYQDTTLNSSSEYCVEKWCRDYFLNCSALRMADVIRAELLEIIKRIELPYAEPAFGSKENTLNIKKALLSGYFMQIARDVDGSGNYLMLTHKQVAQLHPLSGYSITKKMPEWVLFHKFSISENNYIRITSEISPELFMQLVPQYYFSNLPPSESKDILQQVVDHLSPVSTMNKEQQMCETCPETEQRCTLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEEEGLEC -------CCCCCCCC	15.33	22814378
11	Phosphorylation	EGLECPNSSSEKRYF CCCCCCCCCCCCCCC	22.00	25627689
12	Phosphorylation	GLECPNSSSEKRYFP CCCCCCCCCCCCCCC	49.51	25627689
13	Phosphorylation	LECPNSSSEKRYFPE CCCCCCCCCCCCCCC	47.13	25627689
21	Phosphorylation	EKRYFPESLDSSDGD CCCCCCCCCCCCCCC	37.40	22468782
24	Phosphorylation	YFPESLDSSDGDEEE CCCCCCCCCCCCHHH	35.31	22468782
25	Phosphorylation	FPESLDSSDGDEEEV CCCCCCCCCCCHHHE	45.33	28102081
66	Ubiquitination	REDLPIWKEKYSFME HCCCCCHHHHHHHHH	45.08	21906983
66 (in isoform 1)	Ubiquitination	-	45.08	21890473
66 (in isoform 2)	Ubiquitination	-	45.08	21890473
68	Ubiquitination	DLPIWKEKYSFMENL CCCCHHHHHHHHHHH	42.33	22817900
191	Phosphorylation	LDDIHERSIATDVLL ECCHHHHHHHHHHHH	17.37	20068231
194	Phosphorylation	IHERSIATDVLLGLL HHHHHHHHHHHHHHH	25.60	20068231
224	Ubiquitination	SSPHLISKLNSYYGN CCHHHHHHHHHHCCC	44.70	23000965
224 (in isoform 2)	Ubiquitination	-	44.70	-
227	Phosphorylation	HLISKLNSYYGNVPV HHHHHHHHHCCCCCE	30.12	28857561
238	Ubiquitination	NVPVIEVKNKHPVEV CCCEEEEECCCCEEE	47.70	21906983
238 (in isoform 2)	Ubiquitination	-	47.70	21890473
238 (in isoform 1)	Ubiquitination	-	47.70	21890473
240	Ubiquitination	PVIEVKNKHPVEVVY CEEEEECCCCEEEEE	43.50	22817900
313	Ubiquitination	VVVPLYPKEKCSLFK EEEECCCHHHCCCCC	57.14	29967540
315	Ubiquitination	VPLYPKEKCSLFKPL EECCCHHHCCCCCCC	34.94	29967540
317	Phosphorylation	LYPKEKCSLFKPLDE CCCHHHCCCCCCCCH	48.16	24719451
320	Ubiquitination	KEKCSLFKPLDETEK HHHCCCCCCCCHHHH	50.38	29967540
353 (in isoform 2)	Ubiquitination	-	21.67	-
374	Phosphorylation	NPRIRANSLVMQPIS CCCCCCCCEECCCCC	22.74	28857561
389	Ubiquitination	QSQAEIRKQILGSSS HHHHHHHHHHHCCCC	47.56	27667366
395	Phosphorylation	RKQILGSSSSGKFFC HHHHHCCCCCCCEEE	27.07	21712546
396	Phosphorylation	KQILGSSSSGKFFCL HHHHCCCCCCCEEEE	44.82	21712546
410	Phosphorylation	LYTEEFASKDMTPLK EEEHHHCCCCCCCCC	34.21	21712546
414	Phosphorylation	EFASKDMTPLKPAEM HHCCCCCCCCCHHHH	35.29	-
434	Ubiquitination	TSMVLFMKRIDIAGL HHHHHHHHHCCCCCC	38.58	21963094
488 (in isoform 2)	Ubiquitination	-	44.70	21890473
515 (in isoform 2)	Ubiquitination	-	5.06	21890473
536	Phosphorylation	AALTCWKTFLHPEGD HHHHHHHHHCCCCCC	13.61	26503514
561	Phosphorylation	YQDTTLNSSSEYCVE HHCCCCCCCCHHHHH	38.05	25159151
562	Phosphorylation	QDTTLNSSSEYCVEK HCCCCCCCCHHHHHH	26.56	21815630
563	Phosphorylation	DTTLNSSSEYCVEKW CCCCCCCCHHHHHHH	32.19	30576142
565	Phosphorylation	TLNSSSEYCVEKWCR CCCCCCHHHHHHHHH	12.07	27251275
569	Ubiquitination	SSEYCVEKWCRDYFL CCHHHHHHHHHHHHC	31.06	21906983
569 (in isoform 1)	Ubiquitination	-	31.06	21890473
596 (in isoform 1)	Ubiquitination	-	53.65	21890473
596	Ubiquitination	AELLEIIKRIELPYA HHHHHHHHHCCCCCC	53.65	23000965
610	Ubiquitination	AEPAFGSKENTLNIK CCCCCCCCCCCCCHH	56.19	33845483
617	Ubiquitination	KENTLNIKKALLSGY CCCCCCHHHHHHHHH	30.81	29967540
642	Phosphorylation	SGNYLMLTHKQVAQL CCCEEEEEEHHHHHH	17.04	20860994
653	Phosphorylation	VAQLHPLSGYSITKK HHHHCCCCCCCCCCC	39.89	24043423
655	Phosphorylation	QLHPLSGYSITKKMP HHCCCCCCCCCCCCC	8.10	24043423
656	Phosphorylation	LHPLSGYSITKKMPE HCCCCCCCCCCCCCC	27.57	24043423
658	Phosphorylation	PLSGYSITKKMPEWV CCCCCCCCCCCCCEE	20.76	24043423
659	Ubiquitination	LSGYSITKKMPEWVL CCCCCCCCCCCCEEE	45.46	29967540
718	Phosphorylation	QQVVDHLSPVSTMNK HHHHHHCCCCCCCCH	21.60	22199227
721	Phosphorylation	VDHLSPVSTMNKEQQ HHHCCCCCCCCHHHH	25.89	20068231
722	Phosphorylation	DHLSPVSTMNKEQQM HHCCCCCCCCHHHHH	25.62	20068231
725	Ubiquitination	SPVSTMNKEQQMCET CCCCCCCHHHHHHHC	46.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHX32_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHX32_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHX32_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
F161A_HUMAN	FAM161A	physical	25416956
NUDC1_HUMAN	NUDCD1	physical	28514442
RM16_HUMAN	MRPL16	physical	28514442
RPOM_HUMAN	POLRMT	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.