dbPTM

DCE2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DCE2_HUMAN
UniProt AC	Q05329
Protein Name	Glutamate decarboxylase 2
Gene Name	GAD2
Organism	Homo sapiens (Human).
Sequence Length	585
Subcellular Localization	Cytoplasm, cytosol . Cytoplasmic vesicle . Cell junction, synapse, presynaptic cell membrane Lipid-anchor . Golgi apparatus membrane Peripheral membrane protein Cytoplasmic side . Associated to cytoplasmic vesicles. In neurons, cytosolic leafle
Protein Description	Catalyzes the production of GABA..
Protein Sequence	MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGGSQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYLYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEYGTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASPGSGFWS -----CCCCCCCCCC	28.61	8999827
6	Phosphorylation	--MASPGSGFWSFGS --CCCCCCCCCCCCC	33.91	8999827
10	Phosphorylation	SPGSGFWSFGSEDGS CCCCCCCCCCCCCCC	19.91	22817900
13	Phosphorylation	SGFWSFGSEDGSGDS CCCCCCCCCCCCCCC	30.42	22817900
30	S-palmitoylation	PGTARAWCQVAQKFT CHHHHHHHHHHHHHH	1.97	12356867
45	S-palmitoylation	GGIGNKLCALLYGDA CCHHHHHHHHHHCCC	2.40	12356867
58	Phosphorylation	DAEKPAESGGSQPPR CCCCCHHCCCCCCCH	51.03	22210691
61	Phosphorylation	KPAESGGSQPPRAAA CCHHCCCCCCCHHHH	42.93	22210691
95	Phosphorylation	NYAFLHATDLLPACD CCEEEHHHCCCCCCC	19.21	-
121	Phosphorylation	VMNILLQYVVKSFDR HHHHHHHHHHHHCCC	13.74	26699800
125	Phosphorylation	LLQYVVKSFDRSTKV HHHHHHHHCCCCCCE	22.29	26699800
169	Phosphorylation	HCQTTLKYAIKTGHP HHHHHHHHHHHCCCC	19.37	-
296	Phosphorylation	AAALGIGTDSVILIK HHHCCCCCCEEEEEE	24.15	-
298	Phosphorylation	ALGIGTDSVILIKCD HCCCCCCEEEEEEEC	15.76	-
396	N6-(pyridoxal phosphate)lysine	SVTWNPHKMMGVPLQ CCCCCCCCCCCCCCC	31.66	-
396	Other	SVTWNPHKMMGVPLQ CCCCCCCCCCCCCCC	31.66	-
515	Phosphorylation	YIPPSLRTLEDNEER ECCCHHHCCCCHHHH	39.53	-
546	Phosphorylation	EYGTTMVSYQPLGDK HHCCEEEEEEECCCC	13.76	-
547	Phosphorylation	YGTTMVSYQPLGDKV HCCEEEEEEECCCCC	11.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DCE2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DCE2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DCE2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCE1_HUMAN	GAD1	physical	7836456
AR6P1_HUMAN	ARL6IP1	physical	25416956
ATRAP_HUMAN	AGTRAP	physical	25416956
TM159_HUMAN	TMEM159	physical	25416956
MAL2_HUMAN	MAL2	physical	25416956
CKLF5_HUMAN	CMTM5	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DCE2_HUMAN

Related Literatures of Post-Translational Modification

Palmitoylation
Reference	PubMed
"A combination of three distinct trafficking signals mediates axonaltargeting and presynaptic clustering of GAD65."; Kanaani J., El-Din El-Husseini A., Aguilera-Moreno A., Diacovo J.M.,Bredt D.S., Baekkeskov S.; J. Cell Biol. 158:1229-1238(2002). Cited for: SUBCELLULAR LOCATION, AND PALMITOYLATION AT CYS-30 AND CYS-45.	12356867 [Abstract]
Phosphorylation
Reference	PubMed
"Phosphorylation of serine residues 3, 6, 10, and 13 distinguishesmembrane anchored from soluble glutamic acid decarboxylase 65 and isrestricted to glutamic acid decarboxylase 65alpha."; Namchuk M., Lindsay L., Turck C.W., Kanaani J., Baekkeskov S.; J. Biol. Chem. 272:1548-1557(1997). Cited for: PHOSPHORYLATION AT SER-3; SER-6; SER-10 AND SER-13, ANDBIOPHYSICOCHEMICAL PROPERTIES.	8999827 [Abstract]