DCE1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCE1_HUMAN
• UniProt AC: Q99259
• Protein Name: Glutamate decarboxylase 1
• Gene Name: GAD1
• Organism: Homo sapiens (Human).
• Sequence Length: 594
• Protein Description: Catalyzes the production of GABA..
• Protein Sequence: MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEKSRLVSAFKERQSSKNLLSCENSDRDARFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEQSHYSIKKAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAPKIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERLGQDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MASSTPSSSATS ---CCCCCCCCCCCC	25.37	22210691
22	Phosphorylation	AGADPNTTNLRPTTY CCCCCCCCCCCCCCH	38.61	22210691
28	Phosphorylation	TTNLRPTTYDTWCGV CCCCCCCCHHHHCHH	23.29	22210691
60	Ubiquitination	RTNSLEEKSRLVSAF HCCCHHHHHHHHHHH	31.34	-
61	Phosphorylation	TNSLEEKSRLVSAFK CCCHHHHHHHHHHHH	33.84	23898821
65	Phosphorylation	EEKSRLVSAFKERQS HHHHHHHHHHHHHHH	32.36	23898821
68	Ubiquitination	SRLVSAFKERQSSKN HHHHHHHHHHHHCCC	52.26	-
74	Ubiquitination	FKERQSSKNLLSCEN HHHHHHCCCCCCCCC	57.78	-
78	Phosphorylation	QSSKNLLSCENSDRD HHCCCCCCCCCCHHH	23.66	-
91	Dephosphorylation	RDARFRRTETDFSNL HHHHHHCCCCHHHHH	38.69	15147202
91	Phosphorylation	RDARFRRTETDFSNL HHHHHHCCCCHHHHH	38.69	15147202
175	Phosphorylation	ILVDCRDTLKYGVRT HHHHHHHHHHHCCCC	13.05	27251275
175 (in isoform 3)	Phosphorylation	-	13.05	27251275
182 (in isoform 3)	Phosphorylation	-	37.12	27251275
192 (in isoform 3)	Phosphorylation	-	15.63	27251275
193	Phosphorylation	RFFNQLSTGLDIIGL HHHHHHHCCCCCEEE	50.81	27251275
193 (in isoform 3)	Phosphorylation	-	50.81	27251275
265	Phosphorylation	YSIMAARYKYFPEVK HHHHHHHHHHCCCCC	12.81	-
293	Phosphorylation	TSEQSHYSIKKAGAA ECCCCCCCCCHHHHC	23.62	24719451
405	N6-(pyridoxal phosphate)lysine	SVTWNPHKMMGVLLQ CCCCCHHHHHHHHHH	31.66	-
405	Other	SVTWNPHKMMGVLLQ CCCCCHHHHHHHHHH	31.66	-
489	Phosphorylation	KCLELAEYLYAKIKN HHHHHHHHHHHHHCC	10.21	18083107
491	Phosphorylation	LELAEYLYAKIKNRE HHHHHHHHHHHCCHH	12.63	18083107
571	Phosphorylation	NFFRMVISNPAATQS CEEEEHHCCCCCCHH	25.92	18452278
578	Phosphorylation	SNPAATQSDIDFLIE CCCCCCHHHHHHHHH	31.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
91	T	Phosphorylation	Kinase	PRKACA	P17612	GPS
91	T	Phosphorylation	Kinase	PKA-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCE1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCE1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
3HAO_HUMAN	HAAO	physical	16189514
DCE2_HUMAN	GAD2	physical	7836456
STK3_HUMAN	STK3	physical	25416956
3HAO_HUMAN	HAAO	physical	25416956
ATRAP_HUMAN	AGTRAP	physical	25416956
CKLF5_HUMAN	CMTM5	physical	25416956
FGFR1_HUMAN	FGFR1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 603513: Cerebral palsy, spastic quadriplegic 1 (CPSQ1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.