DBP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DBP_MOUSE
• UniProt AC: Q60925
• Protein Name: D site-binding protein
• Gene Name: Dbp
• Organism: Mus musculus (Mouse).
• Sequence Length: 325
• Subcellular Localization: Nucleus.
• Protein Description: This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation (By similarity)..
• Protein Sequence: MARPLSDRTPGPLLLGGPAGAPPGGGALLGLRSLLQGNSKPKEPASCLLKEKERKATLPSAPVPGPGLETAGPADAPSGAVSGGGSPRGRSGPVAGPSLFAPLLWERTLPFGDVEYVDLDAFLLEHGLPPSPPPPGGLSPAPSPARTPAPSPGPGSCSSSSPRSSPGHAPARATLGAAGGHRAGLTSRDTPSPVDPDTVEVLMTFEPDPADLALSSIPGHETFDPRRHRFSEEELKPQPIMKKARKVQVPEEQKDEKYWSRRYKNNEAAKRSRDARRLKENQISVRAAFLEKENALLRQEVVAVRQELSHYRAVLSRYQAQHGTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	VPGPGLETAGPADAP CCCCCCCCCCCCCCC	41.79	28285833
78	Phosphorylation	AGPADAPSGAVSGGG CCCCCCCCCCCCCCC	40.90	27742792
82	Phosphorylation	DAPSGAVSGGGSPRG CCCCCCCCCCCCCCC	31.05	26824392
86	Phosphorylation	GAVSGGGSPRGRSGP CCCCCCCCCCCCCCC	18.07	26824392
158	Phosphorylation	SPGPGSCSSSSPRSS CCCCCCCCCCCCCCC	34.65	29899451
161	Phosphorylation	PGSCSSSSPRSSPGH CCCCCCCCCCCCCCC	26.70	25195567
164	Phosphorylation	CSSSSPRSSPGHAPA CCCCCCCCCCCCCCC	44.24	23684622
165	Phosphorylation	SSSSPRSSPGHAPAR CCCCCCCCCCCCCCH	35.86	23384938
271	Methylation	KNNEAAKRSRDARRL HCCHHHHHHHHHHHH	32.00	-
273	Methylation	NEAAKRSRDARRLKE CHHHHHHHHHHHHHH	45.71	-
284	Phosphorylation	RLKENQISVRAAFLE HHHHHHHHHHHHHHH	8.86	23882026

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DBP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DBP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DBP_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TEF_MOUSE	Tef	physical	20211142
TF2H2_MOUSE	Gtf2h2	physical	20211142
JDP2_MOUSE	Jdp2	physical	20211142
HLF_MOUSE	Hlf	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.