TEF_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TEF_MOUSE
• UniProt AC: Q9JLC6
• Protein Name: Thyrotroph embryonic factor
• Gene Name: Tef
• Organism: Mus musculus (Mouse).
• Sequence Length: 301
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3' (By similarity). Also activates the telokin promoter in smooth muscle-specific and calcium-dependent manner..
• Protein Sequence: MSDAGGGKKPPVEPQAGPGPGRAAGERGLSGSFPLVLKKLMENPPRETRLDKEKGKEKLEEDESAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAQNLLLPVAELEGKESASSSTASPPSSSTAIFQPSETVSSTESSLEKERETPSPIDPSCVEVDVNFNPDPADLVLSSVPGGELFNPRKHRFAEEDLKPQPMIKKAKKVFVPDEQKDEKYWTRRKKNNVAAKRSRDARRLKENQITIRAAFLEKENTALRTEVAELRKEVGKCKTIVSKYETKYGPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDAGGGKK ------CCCCCCCCC	35.85	29514104
30	Phosphorylation	AAGERGLSGSFPLVL CCHHCCCCCCHHHHH	34.90	28066266
38	Acetylation	GSFPLVLKKLMENPP CCHHHHHHHHHHCCC	36.06	22826441
54	Acetylation	ETRLDKEKGKEKLEE CCCCCHHHHHHHHHH	79.58	7719875
131	Phosphorylation	AELEGKESASSSTAS HHHCCCCCCCCCCCC	36.62	25338131
166	Phosphorylation	SLEKERETPSPIDPS HHHHHCCCCCCCCHH	34.98	26643407
168	Phosphorylation	EKERETPSPIDPSCV HHHCCCCCCCCHHHE	41.74	26643407
173	Phosphorylation	TPSPIDPSCVEVDVN CCCCCCHHHEEEECC	27.35	26643407
247	Methylation	KNNVAAKRSRDARRL HHCHHHHHHHHHHHH	32.00	16288571
249	Methylation	NVAAKRSRDARRLKE CHHHHHHHHHHHHHH	45.71	16288581
271	Phosphorylation	AFLEKENTALRTEVA HHHHHHHHHHHHHHH	28.32	25159016
275	Phosphorylation	KENTALRTEVAELRK HHHHHHHHHHHHHHH	35.34	25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TEF_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TEF_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TEF_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TEF_MOUSE	Tef	physical	20211142
HES6_MOUSE	Hes6	physical	20211142
TEF_MOUSE	Tef	physical	1916262
DBP_MOUSE	Dbp	physical	1916262

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.