TF2H2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TF2H2_MOUSE
• UniProt AC: Q9JIB4
• Protein Name: General transcription factor IIH subunit 2
• Gene Name: Gtf2h2
• Organism: Mus musculus (Mouse).
• Sequence Length: 396
• Subcellular Localization: Nucleus .
• Protein Description: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter..
• Protein Sequence: MDEEPERTKRWEGGYERTWEILKEDETGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSLKKAVDMTCHGEPSLYNSLSMAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYDLIKTLKTAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDETHYKELLAHHVSPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDNNSTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEISLEEYKGERFCYGCQGELKDQHVYVCTVCQNVFCVDCDVFVHDSLHCCPGCIHKIPTPSGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	WEGGYERTWEILKED CCCCHHHHHHEEECC	18.60	25619855
27	Phosphorylation	EILKEDETGSLKATI HEEECCCCCCCEEEH	44.38	25619855
29	Phosphorylation	LKEDETGSLKATIED EECCCCCCCEEEHHH	33.83	25619855
40	Ubiquitination	TIEDILFKAKRKRVF EHHHHHHHHHHHHHH	49.94	-
82	Phosphorylation	DLKPNRLTCTLKLLE CCCCCHHHHHHHHHH	10.54	28059163
84	Phosphorylation	KPNRLTCTLKLLEYF CCCHHHHHHHHHHHH	22.99	28059163
95	Phosphorylation	LEYFVEEYFDQNPIS HHHHHHHHCCCCCCH	10.03	-
110	Acetylation	QIGIIVTKSKRAEKL HEEEEEECCHHHHHH	42.98	19861695

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TF2H2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TF2H2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TF2H2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TF2H3_MOUSE	Gtf2h3	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.