DACT3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DACT3_HUMAN
• UniProt AC: Q96B18
• Protein Name: Dapper homolog 3
• Gene Name: DACT3
• Organism: Homo sapiens (Human).
• Sequence Length: 629
• Protein Description: May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins..
• Protein Sequence: MIRAFSFPVSPERGRLRGWLEGSLAGLCELHWLRERQEYRVQQALRLAQPGMGGAEAEDEEDADEDEDAAAARRAAAALEEQLEALPGLVWDLGQQLGDLSLESGGLEQESGRSSGFYEDPSSTGGPDSPPSTFCGDSGFSGSSSYGRLGPSEPRGIYASERPKSLGDASPSAPEVVGARAAVPRSFSAPYPTAGGSAGPEACSSAERRARAGPFLTPSPLHAVAMRSPRPCGRPPTDSPDAGGAGRPLDGYISALLRRRRRRGAGQPRTSPGGADGGPRRQNSVRQRPPDASPSPGSARPAREPSLERVGGHPTSPAALSRAWASSWESEAAPEPAAPPAAPSPPDSPAEGRLVKAQYIPGAQAATRGLPGRAARRKPPPLTRGRSVEQSPPRERPRAAGRRGRMAEASGRRGSPRARKASRSQSETSLLGRASAVPSGPPKYPTAEREEPRPPRPRRGPAPTLAAQAAGSCRRWRSTAEIDAADGRRVRPRAPAARVPGPGPSPSAPQRRLLYGCAGSDSECSAGRLGPLGRRGPAGGVGGGYGESESSASEGESPAFSSASSDSDGSGGLVWPQQLVAATAASGGGAGAGAPAGPAKVFVKIKASHALKKKILRFRSGSLKVMTTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MIRAFSFPVSPER --CCCEEECCCCCCC	27.88	24972180
10	Phosphorylation	RAFSFPVSPERGRLR CEEECCCCCCCCCCH	22.68	25850435
129	Phosphorylation	SSTGGPDSPPSTFCG CCCCCCCCCCCCCCC	41.67	24076635
158	Phosphorylation	PSEPRGIYASERPKS CCCCCCEECCCCCCC	13.60	27642862
160	Phosphorylation	EPRGIYASERPKSLG CCCCEECCCCCCCCC	19.71	24719451
165	Phosphorylation	YASERPKSLGDASPS ECCCCCCCCCCCCCC	40.02	30266825
170	Phosphorylation	PKSLGDASPSAPEVV CCCCCCCCCCCCHHH	24.91	30266825
172	Phosphorylation	SLGDASPSAPEVVGA CCCCCCCCCCHHHCC	54.69	30266825
186	Phosphorylation	ARAAVPRSFSAPYPT CCEECCCCCCCCCCC	19.92	28857561
188	Phosphorylation	AAVPRSFSAPYPTAG EECCCCCCCCCCCCC	29.58	26657352
191	Phosphorylation	PRSFSAPYPTAGGSA CCCCCCCCCCCCCCC	16.97	30576142
193	Phosphorylation	SFSAPYPTAGGSAGP CCCCCCCCCCCCCCH	31.90	30576142
197	Phosphorylation	PYPTAGGSAGPEACS CCCCCCCCCCHHHHH	29.18	27251275
204	Phosphorylation	SAGPEACSSAERRAR CCCHHHHHHHHHHHH	39.36	30576142
205	Phosphorylation	AGPEACSSAERRARA CCHHHHHHHHHHHHC	33.75	27251275
217	Phosphorylation	ARAGPFLTPSPLHAV HHCCCCCCCCCHHHH	23.31	27732954
219	Phosphorylation	AGPFLTPSPLHAVAM CCCCCCCCCHHHHHC	34.55	27732954
239	Phosphorylation	CGRPPTDSPDAGGAG CCCCCCCCCCCCCCC	27.45	-
258	Methylation	GYISALLRRRRRRGA HHHHHHHHHHHHCCC	30.80	-
295	Phosphorylation	RPPDASPSPGSARPA CCCCCCCCCCCCCCC	39.12	26699800
298	Phosphorylation	DASPSPGSARPAREP CCCCCCCCCCCCCCC	25.21	26699800
306	Phosphorylation	ARPAREPSLERVGGH CCCCCCCCCCCCCCC	37.80	26699800
315	Phosphorylation	ERVGGHPTSPAALSR CCCCCCCCCHHHHHH	41.49	28857561
316	Phosphorylation	RVGGHPTSPAALSRA CCCCCCCCHHHHHHH	19.59	28450419
321	Phosphorylation	PTSPAALSRAWASSW CCCHHHHHHHHHHHH	18.41	28450419
344	Phosphorylation	AAPPAAPSPPDSPAE CCCCCCCCCCCCCCC	44.32	25921289
348	Phosphorylation	AAPSPPDSPAEGRLV CCCCCCCCCCCCCEE	31.61	25921289
368	Methylation	PGAQAATRGLPGRAA CCHHHHHCCCCCHHH	39.67	-
387	Phosphorylation	PPLTRGRSVEQSPPR CCCCCCCCCCCCCCC	32.60	26699800
391	Phosphorylation	RGRSVEQSPPRERPR CCCCCCCCCCCCCCC	24.30	26699800
410	Phosphorylation	RGRMAEASGRRGSPR HHHHHHHHCCCCCHH	25.08	-
422	Phosphorylation	SPRARKASRSQSETS CHHHHHHHCCCCHHH	35.18	-
424	O-linked_Glycosylation	RARKASRSQSETSLL HHHHHHCCCCHHHHH	35.25	30379171
424	Phosphorylation	RARKASRSQSETSLL HHHHHHCCCCHHHHH	35.25	28450419
426	Phosphorylation	RKASRSQSETSLLGR HHHHCCCCHHHHHHC	44.05	19664994
428	Phosphorylation	ASRSQSETSLLGRAS HHCCCCHHHHHHCHH	29.89	28450419
429	Phosphorylation	SRSQSETSLLGRASA HCCCCHHHHHHCHHH	19.97	27732954
429	O-linked_Glycosylation	SRSQSETSLLGRASA HCCCCHHHHHHCHHH	19.97	30379171
435	Phosphorylation	TSLLGRASAVPSGPP HHHHHCHHHCCCCCC	28.56	27251275
439	Phosphorylation	GRASAVPSGPPKYPT HCHHHCCCCCCCCCC	58.28	28348404
446	Phosphorylation	SGPPKYPTAEREEPR CCCCCCCCCCCCCCC	37.75	-
472	Phosphorylation	LAAQAAGSCRRWRST HHHHHHHCCCCCCCC	10.34	23312004
478	Phosphorylation	GSCRRWRSTAEIDAA HCCCCCCCCEEEECC	25.63	23401153
479	Phosphorylation	SCRRWRSTAEIDAAD CCCCCCCCEEEECCC	21.53	25850435
505	Phosphorylation	RVPGPGPSPSAPQRR CCCCCCCCCCCCHHH	37.08	26657352
507	Phosphorylation	PGPGPSPSAPQRRLL CCCCCCCCCCHHHHC	57.85	26657352
515	Phosphorylation	APQRRLLYGCAGSDS CCHHHHCEECCCCCC	18.10	29978859
520	Phosphorylation	LLYGCAGSDSECSAG HCEECCCCCCCCCCC	21.31	19664994
522	Phosphorylation	YGCAGSDSECSAGRL EECCCCCCCCCCCCC	42.05	28450419
525	Phosphorylation	AGSDSECSAGRLGPL CCCCCCCCCCCCCCC	29.70	28450419
620	Phosphorylation	KKILRFRSGSLKVMT HHHHHHCCCCCEEEE	29.98	29514088
622	Phosphorylation	ILRFRSGSLKVMTTV HHHHCCCCCEEEEEC	26.68	29514088

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DACT3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DACT3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DACT3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCTD3_HUMAN	KCTD3	physical	27173435
KI13B_HUMAN	KIF13B	physical	27173435
ZBT21_HUMAN	ZBTB21	physical	27173435
GGYF1_HUMAN	GIGYF1	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.