CTR1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CTR1_ARATH
• UniProt AC: Q05609
• Protein Name: Serine/threonine-protein kinase CTR1 {ECO:0000303|PubMed:8431946}
• Gene Name: CTR1 {ECO:0000303|PubMed:8431946}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 821
• Protein Description: Acts as a negative regulator in the ethylene response pathway. [PubMed: 8431946 Phosphorylates the cytosolic C-terminal domain of EIN2, preventing the signaling in the absence of ethylene]
• Protein Sequence: MEMPGRRSNYTLLSQFSDDQVSVSVTGAPPPHYDSLSSENRSNHNSGNTGKAKAERGGFDWDPSGGGGGDHRLNNQPNRVGNNMYASSLGLQRQSSGSSFGESSLSGDYYMPTLSAAANEIESVGFPQDDGFRLGFGGGGGDLRIQMAADSAGGSSSGKSWAQQTEESYQLQLALALRLSSEATCADDPNFLDPVPDESALRTSPSSAETVSHRFWVNGCLSYYDKVPDGFYMMNGLDPYIWTLCIDLHESGRIPSIESLRAVDSGVDSSLEAIIVDRRSDPAFKELHNRVHDISCSCITTKEVVDQLAKLICNRMGGPVIMGEDELVPMWKECIDGLKEIFKVVVPIGSLSVGLCRHRALLFKVLADIIDLPCRIAKGCKYCNRDDAASCLVRFGLDREYLVDLVGKPGHLWEPDSLLNGPSSISISSPLRFPRPKPVEPAVDFRLLAKQYFSDSQSLNLVFDPASDDMGFSMFHRQYDNPGGENDALAENGGGSLPPSANMPPQNMMRASNQIEAAPMNAPPISQPVPNRANRELGLDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWHGSDVAVKILMEQDFHAERVNEFLREVAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIKSAVPPPNRSDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	QFSDDQVSVSVTGAP CCCCCEEEEEECCCC	11.75	28011693
24	Phosphorylation	SDDQVSVSVTGAPPP CCCEEEEEECCCCCC	13.37	28011693
151	Phosphorylation	RIQMAADSAGGSSSG EEEEEECCCCCCCCC	24.88	25561503
155	Phosphorylation	AADSAGGSSSGKSWA EECCCCCCCCCCCHH	22.03	19880383
156	Phosphorylation	ADSAGGSSSGKSWAQ ECCCCCCCCCCCHHH	46.51	30407730
157	Phosphorylation	DSAGGSSSGKSWAQQ CCCCCCCCCCCHHHH	52.52	25561503
203	Phosphorylation	PDESALRTSPSSAET CCHHHCCCCCCCCCC	45.93	25561503
204	Phosphorylation	DESALRTSPSSAETV CHHHCCCCCCCCCCC	19.15	29654922
688	Phosphorylation	NLLVDKKYTVKVCDF CEEECCCEEEEECCC	23.62	28295753
689	Phosphorylation	LLVDKKYTVKVCDFG EEECCCEEEEECCCH	23.80	28295753
698	Phosphorylation	KVCDFGLSRLKASTF EECCCHHHHHHHHHH	35.63	28295753
703	Phosphorylation	GLSRLKASTFLSSKS HHHHHHHHHHHCCCC	20.36	25561503
704	Phosphorylation	LSRLKASTFLSSKSA HHHHHHHHHHCCCCC	33.19	30407730
707	Phosphorylation	LKASTFLSSKSAAGT HHHHHHHCCCCCCCC	31.37	23111157
708	Phosphorylation	KASTFLSSKSAAGTP HHHHHHCCCCCCCCC	32.54	25561503
710	Phosphorylation	STFLSSKSAAGTPEW HHHHCCCCCCCCCCC	25.87	30291188
714	Phosphorylation	SSKSAAGTPEWMAPE CCCCCCCCCCCCCCH	17.20	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CTR1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CTR1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CTR1_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTR1_ARATH	CTR1	physical	12787251
ETR1_ARATH	ETR1	physical	12821658
ETR1_ARATH	ETR1	physical	9560288
ERS1_ARATH	ERS1	physical	9560288
CAAT9_ARATH	CAT9	physical	22737156
EIN2_ARATH	EIN2	physical	23132950
ETR2_ARATH	ETR2	physical	25814663
EIN4_ARATH	EIN4	physical	25814663

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.