CRBA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRBA1_HUMAN
• UniProt AC: P05813
• Protein Name: Beta-crystallin A3
• Gene Name: CRYBA1
• Organism: Homo sapiens (Human).
• Sequence Length: 215
• Protein Description: Crystallins are the dominant structural components of the vertebrate eye lens..
• Protein Sequence: METQAEQQELETLPTTKMAQTNPTPGSLGPWKITIYDQENFQGKRMEFTSSCPNVSERSFDNVRSLKVESGAWIGYEHTSFCGQQFILERGEYPRWDAWSGSNAYHIERLMSFRPICSANHKESKMTIFEKENFIGRQWEISDDYPSLQAMGWFNNEVGSMKIQSGAWVCYQYPGYRGYQYILECDHHGGDYKHWREWGSHAQTSQIQSIRRIQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------METQAEQQ -------CCCHHHHH	13.03	8999933
2 (in isoform 2)	Acetylation	-	50.02	8999933
15	Phosphorylation	QELETLPTTKMAQTN HHHHCCCCCCCCCCC	42.01	-
44	Methylation	DQENFQGKRMEFTSS ECCCCCCCEEEEECC	37.48	17022627
82	Methylation	GYEHTSFCGQQFILE CCEECCCCCCEEEEC	4.88	15576560
82	S-glutathionyl cysteine	GYEHTSFCGQQFILE CCEECCCCCCEEEEC	4.88	-
82	Glutathionylation	GYEHTSFCGQQFILE CCEECCCCCCEEEEC	4.88	22833525
112	Phosphorylation	YHIERLMSFRPICSA HHHHHHHHCCCCCCC	23.77	24719451
117	Methylation	LMSFRPICSANHKES HHHCCCCCCCCCCCC	3.31	15576560
117	Glutathionylation	LMSFRPICSANHKES HHHCCCCCCCCCCCC	3.31	22833525
117	S-glutathionyl cysteine	LMSFRPICSANHKES HHHCCCCCCCCCCCC	3.31	-
122	Acetylation	PICSANHKESKMTIF CCCCCCCCCCCEEEE	64.59	12060738
125	Acetylation	SANHKESKMTIFEKE CCCCCCCCEEEEEEC	40.95	12060738
127	Phosphorylation	NHKESKMTIFEKENF CCCCCCEEEEEECCC	26.67	22817900
131	Acetylation	SKMTIFEKENFIGRQ CCEEEEEECCCCCCC	47.40	12060738
137	Methylation	EKENFIGRQWEISDD EECCCCCCCEEECCC	33.35	-
160	Phosphorylation	WFNNEVGSMKIQSGA CCCCCCCCEEEECCC	23.29	22817900
179	Phosphorylation	QYPGYRGYQYILECD ECCCCCCEEEEEEEC	6.80	22817900
181	Phosphorylation	PGYRGYQYILECDHH CCCCCEEEEEEECCC	10.05	22817900
185	Methylation	GYQYILECDHHGGDY CEEEEEEECCCCCCC	5.60	15576560
204	Phosphorylation	EWGSHAQTSQIQSIR HCCCCCCHHHHHHHH	24.31	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRBA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRBA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRBA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CRBA1_HUMAN	CRYBA1	physical	19401464
CRBB1_HUMAN	CRYBB1	physical	25416956
CRBB3_HUMAN	CRYBB3	physical	25416956
RBPMS_HUMAN	RBPMS	physical	25416956
RHXF2_HUMAN	RHOXF2	physical	25416956
CRBB1_HUMAN	CRYBB1	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 600881: Cataract 10, multiple types (CTRCT10)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Shotgun identification of protein modifications from proteincomplexes and lens tissue.";
MacCoss M.J., McDonald W.H., Saraf A., Sadygov R., Clark J.M.,Tasto J.J., Gould K.L., Wolters D., Washburn M., Weiss A., Clark J.I.,Yates J.R. III;
Proc. Natl. Acad. Sci. U.S.A. 99:7900-7905(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-127 AND SER-160,ACETYLATION AT LYS-122; LYS-125 AND LYS-131, METHYLATION AT ARG-137,SUSCEPTIBILITY TO OXIDATION, AND MASS SPECTROMETRY.
PubMed: 12060738

Methylation

"Shotgun identification of protein modifications from proteincomplexes and lens tissue.";
MacCoss M.J., McDonald W.H., Saraf A., Sadygov R., Clark J.M.,Tasto J.J., Gould K.L., Wolters D., Washburn M., Weiss A., Clark J.I.,Yates J.R. III;
Proc. Natl. Acad. Sci. U.S.A. 99:7900-7905(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-127 AND SER-160,ACETYLATION AT LYS-122; LYS-125 AND LYS-131, METHYLATION AT ARG-137,SUSCEPTIBILITY TO OXIDATION, AND MASS SPECTROMETRY.
PubMed: 12060738

Phosphorylation

"Shotgun identification of protein modifications from proteincomplexes and lens tissue.";
MacCoss M.J., McDonald W.H., Saraf A., Sadygov R., Clark J.M.,Tasto J.J., Gould K.L., Wolters D., Washburn M., Weiss A., Clark J.I.,Yates J.R. III;
Proc. Natl. Acad. Sci. U.S.A. 99:7900-7905(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-127 AND SER-160,ACETYLATION AT LYS-122; LYS-125 AND LYS-131, METHYLATION AT ARG-137,SUSCEPTIBILITY TO OXIDATION, AND MASS SPECTROMETRY.
PubMed: 12060738