CP3A5_HUMAN - dbPTM
CP3A5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CP3A5_HUMAN
UniProt AC P20815
Protein Name Cytochrome P450 3A5
Gene Name CYP3A5
Organism Homo sapiens (Human).
Sequence Length 502
Subcellular Localization Endoplasmic reticulum membrane
Peripheral membrane protein. Microsome membrane
Peripheral membrane protein.
Protein Description Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics..
Protein Sequence MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
99PhosphorylationTVLVKECYSVFTNRR
HHHHHHHHHHHCCCC		14.68-
107PhosphorylationSVFTNRRSLGPVGFM
HHHCCCCCCCCCHHH		34.1528857561
110 (in isoform 2)Phosphorylation-28.49-
111 (in isoform 2)Phosphorylation-9.78-
112 (in isoform 2)Phosphorylation-21.77-
127AcetylationLAEDEEWKRIRSLLS
HHCCHHHHHHHHHHC		41.0220167786
134PhosphorylationKRIRSLLSPTFTSGK
HHHHHHHCCCCCCCH		27.4725072903
136PhosphorylationIRSLLSPTFTSGKLK
HHHHHCCCCCCCHHH		35.8525072903
138PhosphorylationSLLSPTFTSGKLKEM
HHHCCCCCCCHHHHH		38.7625072903
139PhosphorylationLLSPTFTSGKLKEMF
HHCCCCCCCHHHHHH		29.7325072903
171PhosphorylationAEKGKPVTLKDIFGA
HHCCCCCCHHHHHCC		36.3024275569
222PhosphorylationFLDPLFLSIILFPFL
CCCHHHHHHHHHHHH		10.55-
284PhosphorylationDSQNSKETESHKALS
CCCCCCCCHHHHHHH		46.6622101235
347PhosphorylationPNKAPPTYDAVVQME
CCCCCCCCCEEEHHH		14.0020058876
463PhosphorylationIRVLQNFSFKPCKET
HHHHHHCCCCCCCCC		39.6524719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CP3A5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CP3A5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CP3A5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RDH13_HUMANRDH13physical
21988832
ETV5_HUMANETV5physical
21988832
CP3A7_HUMANCYP3A7physical
28514442
SPB4_HUMANSERPINB4physical
28514442
Drug and Disease Associations
Kegg Disease
H00036 Osteosarcoma
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00075 Testosterone (JAN/USP); Androderm (TN); Androgel (TN); Axiron (TN); Striant (TN); Testim (TN)
D00088 Hydrocortisone (JP16/USP/INN); HC; Acticort (TN); Anusol HC (TN); Colocort (TN); Cortef (TN); Hytone
D00104 Chloramphenicol (JP16/USP/INN); CP; Amphicol (TN); Chloromycetin (TN); Econochlor (TN)
D00140 Erythromycin (JP16/USP/INN); EM; Akne-mycin (TN); Eryc (TN); Erygel (TN); Pce (TN); Staticin (TN); T
D00186 Ciprofloxacin (JAN/USP/INN); CPFX; Cipro (TN)
D00210 Norfloxacin (JP16/USP/INN); NFLX; Noroxin (TN)
D00320 Fentanyl (JAN/USAN/INN); Duragesic (TN); Subsys (TN)
D00395 Troglitazone (JAN/USAN/INN); Rezulin (TN)
D00424 Rifabutin (JAN/USP/INN); Mycobutin (TN)
D00435 Nevirapine (JAN/USP/INN); Viramune (TN)
D00437 Nifedipine (JP16/USP/INN); Adalat (TN); Afeditab CR (TN); Procardia (TN)
D00483 Propranolol hydrochloride (JP16/USP); Inderal (TN); Innopran XL (TN)
D00528 Anhydrous caffeine (JP16); Caffeine (USP); Anhydrous caffeine (TN)
D00530 Zaleplon (JAN/USAN/INN); Sonata (TN)
D00533 Oxcarbazepine (USAN/INN); Oxtellar (TN); Trileptal (TN)
D00615 Amlodipine besilate (JP16); Amlodipine besylate (USAN); Norvasc (TN)
D00619 Verapamil hydrochloride (JP16/USP); Calan (TN); Covera-hs (TN); Vasolan (TN); Verelan (TN)
D00665 Chlorpheniramine maleate (JP16/USP); Chlor-trimeton (TN); Teldrin (TN)
D00668 d-Chlorpheniramine maleate (JP16); Dexchlorpheniramine maleate (USP); Mylaramine (TN); Polaramine (T
D00672 Hydroxyzine hydrochloride (JP16/USP); Atarax (TN); Vistaril (TN)
D00674 Naratriptan hydrochloride (JAN/USAN); Amerge (TN)
D00851 Erythromycin estorate (JAN); Erythromycin estolate (USP); Ilosone (TN)
D01096 Hydroxyzine pamoate (JP16/USP); Atarax-P (TN); Vistaril pamoate (TN)
D01111 Nateglinide (JP16/USAN/INN); Starsis (TN)
D01399 Fentanyl citrate (JP16/USP); Fentora (TN); Lazanda (TN); Oralet (TN)
D01441 Imatinib mesilate (JAN); Imatinib mesylate (USAN); Gleevec (TN); Glivec (TN)
D01453 Caffeine hydrate (JP16); Caffeine monohydrate; Caffeine (TN)
D01745 Domperidone (JP16/USAN/INN); Motilium (TN)
D01849 Lercanidipine hydrochloride (JAN/USAN); Cardiovasc (TN)
D01939 Ziprasidone hydrochloride hydrate (JAN); Ziprasidone hydrochloride (USAN); Geodon (TN)
D02009 Erythromycin lactobionate (JP16/USP); EML; Erythrocin (TN)
D02100 Ziprasidone mesylate (USAN); Ziprasidone mesylate hydrate; Geodon (TN)
D02184 Erythromycin stearate (JP16/USP); ES; Bristamycin (TN)
D02216 Ciprofloxacin hydrochloride (JAN/USP); CPFX; Ciloxan (TN); Cipro (TN); Proquin XR (TN)
D02261 Quinine hydrochloride hydrate (JP16); Quinine hydrochloride dihydrate; Quinine hydrochloride (TN)
D02262 Quinine sulfate hydrate (JP16); Quinine sulfate (USP); Quinine hydrogen sulfate; Coco-quinine (TN)
D02356 Verapamil (USAN/INN)
D02523 Erythromycin acistrate (USAN); EA; Erasis (TN)
D02524 Erythromycin gluceptate (USP); Erythromycin glucoheptonate; Ilotycin gluceptate (TN)
D02525 Erythromycin propionate (USAN)
D02731 Vardenafil dihydrochoride (USAN); Levitra (TN)
D02914 Amlodipine maleate (USAN); Amvaz (TN)
D03213 Apixaban (JAN/USAN/INN); Eliquis (TN)
D03218 Axitinib (JAN/USAN); Inlyta (TN)
D03729 Dexpropranolol hydrochloride (USAN)
D03820 Dutasteride (JAN/USAN/INN); Avodart (TN)
D04024 Lapatinib tosilate hydrate (JAN); Lapatinib ditosylate (USAN); Tykerb (TN)
D04054 Erythromycin salnacedin (USAN)
D05681 Quinine ascorbate (USAN)
D07086 Rivaroxaban (JAN/USAN/INN); Xarelto (TN)
D07450 Amlodipine (INN); Norvasc (TN)
D07702 Ciprofloxacin lactate; Ciproxin (TN)
D07749 Cortisone (INN); Cortisone (TN)
D07803 Dexchlorpheniramine (INN); d-Chloropheniramine; Dapriton (TN)
D07868 Domperidone maleate; Domperidone (TN)
D07909 Erythromycin thiocyanate; Erythrocin (TN)
D07910 Erythromycin stinoprate (INN); Erysec (TN)
D08054 Hydroxyzine (INN); Marex (TN)
D08066 Imatinib (INN); Glamox (TN)
D08108 Lapatinib (INN)
D08111 Lercanidipine (INN); Lercanil (TN)
D08255 Naratriptan (INN); Naramig (TN)
D08265 Hydroquinine hydrobromide; inhibin (TN)
D08443 Propranolol (INN); Propranolol (TN)
D08460 Quinine (BAN); Kinder Quinina (TN)
D08461 Quinine dihydrochloride; Quinine (TN)
D08687 Ziprasidone (INN); Zipradon (TN)
D09881 Cobicistat (JAN/USAN/INN)
DrugBank
DB05773ado-trastuzumab emtansine
DB00802Alfentanil
DB00404Alprazolam
DB01118Amiodarone
DB00321Amitriptyline
DB00381Amlodipine
DB00701Amprenavir
DB06605Apixaban
DB00673Aprepitant
DB00278Argatroban
DB01238Aripiprazole
DB06697Artemether
DB00637Astemizole
DB01076Atorvastatin
DB06626Axitinib
DB00972Azelastine
DB00394Beclomethasone
DB08873Boceprevir
DB08870Brentuximab vedotin
DB00921Buprenorphine
DB00490Buspirone
DB06772Cabazitaxel
DB00201Caffeine
DB00564Carbamazepine
DB00446Chloramphenicol
DB00608Chloroquine
DB01114Chlorphenamine
DB01166Cilostazol
DB00501Cimetidine
DB00537Ciprofloxacin
DB00604Cisapride
DB01211Clarithromycin
DB00575Clonidine
DB00758Clopidogrel
DB00907Cocaine
DB00318Codeine
DB08865Crizotinib
DB00531Cyclophosphamide
DB00091Cyclosporine
DB00250Dapsone
DB01254Dasatinib
DB00694Daunorubicin
DB00705Delavirdine
DB01234Dexamethasone
DB00514Dextromethorphan
DB00829Diazepam
DB00343Diltiazem
DB00822Disulfiram
DB01248Docetaxel
DB08930Dolutegravir
DB01184Domperidone
DB01126Dutasteride
DB08899Enzalutamide
DB00700Eplerenone
DB00530Erlotinib
DB00199Erythromycin
DB00783Estradiol
DB00655Estrone
DB00593Ethosuximide
DB00773Etoposide
DB01023Felodipine
DB00813Fentanyl
DB01216Finasteride
DB00196Fluconazole
DB00472Fluoxetine
DB00499Flutamide
DB00588Fluticasone Propionate
DB01095Fluvastatin
DB00176Fluvoxamine
DB00317Gefitinib
DB06730Gestodene
DB00889Granisetron
DB01218Halofantrine
DB00502Haloperidol
DB00741Hydrocortisone
DB01181Ifosfamide
DB04946Iloperidone
DB00619Imatinib
DB00224Indinavir
DB00762Irinotecan
DB01167Itraconazole
DB01026Ketoconazole
DB01259Lapatinib
DB00528Lercanidipine
DB01227Levomethadyl Acetate
DB00281Lidocaine
DB00678Losartan
DB00227Lovastatin
DB00333Methadone
DB00683Midazolam
DB00834Mifepristone
DB00745Modafinil
DB00688Mycophenolate mofetil
DB00731Nateglinide
DB01149Nefazodone
DB00220Nelfinavir
DB00238Nevirapine
DB00622Nicardipine
DB01115Nifedipine
DB00393Nimodipine
DB00401Nisoldipine
DB01054Nitrendipine
DB00717Norethindrone
DB01059Norfloxacin
DB00540Nortriptyline
DB00904Ondansetron
DB00842Oxazepam
DB00776Oxcarbazepine
DB01062Oxybutynin
DB00497Oxycodone
DB01229Paclitaxel
DB01267Paliperidone
DB00738Pentamidine
DB08883Perampanel
DB00780Phenelzine
DB01174Phenobarbital
DB00252Phenytoin
DB01100Pimozide
DB08901Ponatinib
DB00175Pravastatin
DB01058Praziquantel
DB00396Progesterone
DB00571Propranolol
DB01224Quetiapine
DB01103Quinacrine
DB00468Quinine
DB00863Ranitidine
DB00206Reserpine
DB01045Rifampicin
DB01201Rifapentine
DB00734Risperidone
DB00503Ritonavir
DB06228Rivaroxaban
DB01098Rosuvastatin
DB00938Salmeterol
DB01232Saquinavir
DB06335Saxagliptin
DB00203Sildenafil
DB00641Simvastatin
DB00877Sirolimus
DB00398Sorafenib
DB00795Sulfasalazine
DB01268Sunitinib
DB00864Tacrolimus
DB00675Tamoxifen
DB00976Telithromycin
DB06287Temsirolimus
DB00444Teniposide
DB00624Testosterone
DB01041Thalidomide
DB00656Trazodone
DB00755Tretinoin
DB00897Triazolam
DB01361Troleandomycin
DB06267Udenafil
DB00313Valproic Acid
DB00862Vardenafil
DB00661Verapamil
DB00541Vincristine
DB00582Voriconazole
DB00943Zalcitabine
DB00962Zaleplon
DB00246Ziprasidone
DB00425Zolpidem
Regulatory Network of CP3A5_HUMAN

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