CP3A7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CP3A7_HUMAN
• UniProt AC: P24462
• Protein Name: Cytochrome P450 3A7
• Gene Name: CYP3A7
• Organism: Homo sapiens (Human).
• Sequence Length: 503
• Subcellular Localization: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
• Protein Description: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics..
• Protein Sequence: MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWREPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	Phosphorylation	YRKVWGIYDCQQPML HHHHHCEECCCCCEE	13.51	-
92	Phosphorylation	TDPDMIKTVLVKECY CCHHHHHHHHHHHHH	14.24	22101235
99	Phosphorylation	TVLVKECYSVFTNRR HHHHHHHHHHHCCCC	14.68	-
100	Phosphorylation	VLVKECYSVFTNRRP HHHHHHHHHHCCCCC	23.55	22101235
103	Phosphorylation	KECYSVFTNRRPFGP HHHHHHHCCCCCCCC	26.17	22101235
134	Phosphorylation	KRIRSLLSPTFTSGK HHHHHHHCCCCCCCC	27.47	25072903
136	Phosphorylation	IRSLLSPTFTSGKLK HHHHHCCCCCCCCHH	35.85	25072903
138	Phosphorylation	SLLSPTFTSGKLKEM HHHCCCCCCCCHHHH	38.76	25072903
139	Phosphorylation	LLSPTFTSGKLKEMV HHCCCCCCCCHHHHH	29.73	25072903
284	Phosphorylation	DSQNSKDSETHKALS CCCCCCCHHHHHHHH	48.40	-
286	Phosphorylation	QNSKDSETHKALSDL CCCCCHHHHHHHHHH	32.40	-
346	Phosphorylation	LPNKAPPTYDTVLQL CCCCCCCCCCCHHHH	32.73	23663014
347	Phosphorylation	PNKAPPTYDTVLQLE CCCCCCCCCCHHHHH	18.52	23663014
349	Phosphorylation	KAPPTYDTVLQLEYL CCCCCCCCHHHHHHH	16.83	23663014
355	Phosphorylation	DTVLQLEYLDMVVNE CCHHHHHHHHHHHHH	19.32	23663014
363	Phosphorylation	LDMVVNETLRLFPVA HHHHHHHHHHHHHHH	16.39	23663014
406	Methylation	YVLHHDPKYWREPEK HHHCCCHHHCCCHHH	64.60	-
420	Phosphorylation	KFLPERFSKKNKDNI HCCCHHHHHCCCCCC	49.28	22101235
432	Phosphorylation	DNIDPYIYTPFGSGP CCCCCCCCCCCCCCC	11.52	-
437	Phosphorylation	YIYTPFGSGPRNCIG CCCCCCCCCCCCCCC	46.10	-
464	Phosphorylation	VRVLQNFSFKPCKET HHHHHHCCCCCCCCC	39.65	24719451
485	Phosphorylation	RFGGLLLTEKPIVLK EECCEEEECCCEEEE	41.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CP3A7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CP3A7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CP3A7_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CP3A7_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.