COAA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COAA1_HUMAN
• UniProt AC: Q03692
• Protein Name: Collagen alpha-1(X) chain
• Gene Name: COL10A1
• Organism: Homo sapiens (Human).
• Sequence Length: 680
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage..
• Protein Sequence: MLPQIPFLLLVSLNLVHGVFYAERYQMPTGIKGPLPNTKTQFFIPYTIKSKGIAVRGEQGTPGPPGPAGPRGHPGPSGPPGKPGYGSPGLQGEPGLPGPPGPSAVGKPGVPGLPGKPGERGPYGPKGDVGPAGLPGPRGPPGPPGIPGPAGISVPGKPGQQGPTGAPGPRGFPGEKGAPGVPGMNGQKGEMGYGAPGRPGERGLPGPQGPTGPSGPPGVGKRGENGVPGQPGIKGDRGFPGEMGPIGPPGPQGPPGERGPEGIGKPGAAGAPGQPGIPGTKGLPGAPGIAGPPGPPGFGKPGLPGLKGERGPAGLPGGPGAKGEQGPAGLPGKPGLTGPPGNMGPQGPKGIPGSHGLPGPKGETGPAGPAGYPGAKGERGSPGSDGKPGYPGKPGLDGPKGNPGLPGPKGDPGVGGPPGLPGPVGPAGAKGMPGHNGEAGPRGAPGIPGTRGPIGPPGIPGFPGSKGDPGSPGPPGPAGIATKGLNGPTGPPGPPGPRGHSGEPGLPGPPGPPGPPGQAVMPEGFIKAGQRPSLSGTPLVSANQGVTGMPVSAFTVILSKAYPAIGTPIPFDKILYNRQQHYDPRTGIFTCQIPGIYYFSYHVHVKGTHVWVGLYKNGTPVMYTYDEYTKGYLDQASGSAIIDLTENDQVWLQLPNAESNGLYSSEYVHSSFSGFLVAPM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	IPFLLLVSLNLVHGV HHHHHHHHHHHHCHH	16.12	22210691
61	Phosphorylation	AVRGEQGTPGPPGPA EECCCCCCCCCCCCC	25.43	22210691
381	Phosphorylation	GAKGERGSPGSDGKP CCCCCCCCCCCCCCC	32.10	27251275
384	Phosphorylation	GERGSPGSDGKPGYP CCCCCCCCCCCCCCC	46.72	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COAA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COAA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COAA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANXA5_HUMAN	ANXA5	physical	1397263
UBQL1_HUMAN	UBQLN1	physical	25416956
BANP_HUMAN	BANP	physical	25416956
C1QL4_HUMAN	C1QL4	physical	28514442
C1QRF_HUMAN	C1QL1	physical	28514442
TOM34_HUMAN	TOMM34	physical	28514442
GT252_HUMAN	COLGALT2	physical	28514442
NUMB_HUMAN	NUMB	physical	28514442
CO4A2_HUMAN	COL4A2	physical	28514442
EM55_HUMAN	MPP1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.