CLE26_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLE26_ARATH
• UniProt AC: O04547
• Protein Name: CLAVATA3/ESR (CLE)-related protein 26
• Gene Name: CLE26
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 118
• Subcellular Localization: Secreted, extracellular space.
• Protein Description: Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance..
• Protein Sequence: MRNNHSLRLQLWFRTLFTVGVVTLLMIDAFVLQNNKEDDKTKEITTAVNMNNSDAKEIQQELEDGSRNDDLSYVASKRKVPRGPDPIHNRFLLLSRFILSLLTNPYPYLHICVLDVSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	N-linked_Glycosylation	ITTAVNMNNSDAKEI HHHHHHCCCCCHHHH	39.38	-
81	Hydroxylation	VASKRKVPRGPDPIH HHHCCCCCCCCCCHH	38.25	-
84	Hydroxylation	KRKVPRGPDPIHNRF CCCCCCCCCCHHHHH	45.55	-
84	O-linked_Glycosylation	KRKVPRGPDPIHNRF CCCCCCCCCCHHHHH	45.55	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLE26_ARATH !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
84	P	Glycosylation	[CLE26p]: The O-glycosylation (arabinosylation) of the hydroxyproline Pro-84 enhances binding affinity of the CLE26p peptide for its receptor.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLE26_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HHP2_ARATH	HHP2	physical	24833385
HHP4_ARATH	HHP4	physical	24833385
UBC34_ARATH	UBC34	physical	24833385
AB12I_ARATH	AT3G21580	physical	24833385
CNIH1_ARATH	AT3G12180	physical	24833385
CP21D_ARATH	AT3G66654	physical	24833385
WAK3_ARATH	WAK3	physical	24833385
PAM74_ARATH	AT5G59650	physical	24833385
BETL2_ARATH	AT1G29060	physical	24833385
BET12_ARATH	ATBET12	physical	24833385
TBL18_ARATH	TBL18	physical	24833385

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.