CIPKC_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CIPKC_ARATH
• UniProt AC: Q9SN43
• Protein Name: CBL-interacting serine/threonine-protein kinase 12
• Gene Name: CIPK12
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 489
• Protein Description: CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner (By similarity)..
• Protein Sequence: MAEKITRETSLPKERSSPQALILGRYEMGKLLGHGTFAKVYLARNVKTNESVAIKVIDKEKVLKGGLIAHIKREISILRRVRHPNIVQLFEVMATKAKIYFVMEYVRGGELFNKVAKGRLKEEVARKYFQQLISAVTFCHARGVYHRDLKPENLLLDENGNLKVSDFGLSAVSDQIRQDGLFHTFCGTPAYVAPEVLARKGYDAAKVDIWSCGVILFVLMAGYLPFHDRNVMAMYKKIYRGEFRCPRWFSTELTRLLSKLLETNPEKRFTFPEIMENSWFKKGFKHIKFYVEDDKLCNVVDDDELESDSVESDRDSAASESEIEYLEPRRRVGGLPRPASLNAFDIISFSQGFDLSGLFDDDGEGSRFVSGAPVSKIISKLEEIAKVVSFTVRKKDCRVSLEGSRQGVKGPLTIAAEIFELTPSLVVVEVKKKGGDKTEYEDFCNNELKPKLQNLTADDVVAEPVAVSAVDETAIPNSPTISFLPSDTE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	EKITRETSLPKERSS CCCCCCCCCCCCCCC	37.61	26658240
16	Phosphorylation	TSLPKERSSPQALIL CCCCCCCCCCCEEEE	47.68	25561503
17	Phosphorylation	SLPKERSSPQALILG CCCCCCCCCCEEEEE	27.53	29654922
51	Phosphorylation	RNVKTNESVAIKVID CCCCCCCCEEEEEEC	20.93	26811356
170	Phosphorylation	KVSDFGLSAVSDQIR CCCCCCHHHHCHHHH	27.31	-
184	Phosphorylation	RQDGLFHTFCGTPAY HHCCCCCCCCCCCCC	17.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CIPKC_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CIPKC_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CIPKC_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
14333_ARATH	GRF3	physical	21798944
CNBL2_ARATH	CBL2	physical	21798944
CNBL4_ARATH	SOS3	physical	24970010
CNBL7_ORYSJ	Os02g0291000	physical	24970010
CNBL4_ORYSJ	Os05g0534400	physical	24970010
CNBL5_ORYSJ	Os01g0598200	physical	24970010

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.