CDKL4_HUMAN - dbPTM
CDKL4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CDKL4_HUMAN
UniProt AC Q5MAI5
Protein Name Cyclin-dependent kinase-like 4
Gene Name CDKL4
Organism Homo sapiens (Human).
Sequence Length 379
Subcellular Localization Cytoplasm .
Protein Description
Protein Sequence MEKYEKLAKTGEGSYGVVFKCRNKTSGQVVAVKKFVESEDDPVVKKIALREIRMLKQLKHPNLVNLIEVFRRKRKMHLVFEYCDHTLLNELERNPNGVADGVIKSVLWQTLQALNFCHIHNCIHRDIKPENILITKQGIIKICDFGFAQILIPGDAYTDYVATRWYRAPELLVGDTQYGSSVDIWAIGCVFAELLTGQPLWPGKSDVDQLYLIIRTLGKLIPRHQSIFKSNGFFHGISIPEPEDMETLEEKFSDVHPVALNFMKGCLKMNPDDRLTCSQLLESSYFDSFQEAQIKRKARNEGRNRRRQQQAPKSAFPRLFLKTKICQVQRNETQTSGNQILPNGPILQNSMVTVMTNINSAVYQVTVLHLLSENFEVKS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
25PhosphorylationVFKCRNKTSGQVVAV
EEEEECCCCCCEEEE		41.4622210691
33AcetylationSGQVVAVKKFVESED
CCCEEEEEEEECCCC		30.6530587569
160PhosphorylationPGDAYTDYVATRWYR
CCCHHHHHHHHCEEC		5.5626074081
163PhosphorylationAYTDYVATRWYRAPE
HHHHHHHHCEECCCE		16.2226074081
226PhosphorylationKLIPRHQSIFKSNGF
HHCHHHHHHHHHCCC		24.7024719451
276PhosphorylationMNPDDRLTCSQLLES
CCCCCCCCHHHHHHH		15.8230576142
278PhosphorylationPDDRLTCSQLLESSY
CCCCCCHHHHHHHHC		20.7330576142
283PhosphorylationTCSQLLESSYFDSFQ
CHHHHHHHHCCHHHH		30.2430576142
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CDKL4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CDKL4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CDKL4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HS90A_HUMANHSP90AA1physical
26186194
HS90B_HUMANHSP90AB1physical
26186194
POTEI_HUMANPOTEIphysical
26186194
FKBP5_HUMANFKBP5physical
26186194
DNMT1_HUMANDNMT1physical
26186194
MY18A_HUMANMYO18Aphysical
26186194
ZN703_HUMANZNF703physical
26186194
POTEI_HUMANPOTEIphysical
28514442
FKBP5_HUMANFKBP5physical
28514442
MY18A_HUMANMYO18Aphysical
28514442
HS90A_HUMANHSP90AA1physical
28514442
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CDKL4_HUMAN

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Related Literatures of Post-Translational Modification

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