CDC28_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CDC28_SCHPO
• UniProt AC: Q10752
• Protein Name: Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein cdc28
• Gene Name: cdc28
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1055
• Subcellular Localization: Nucleus.
• Protein Description: Involved in pre-mRNA splicing. Is required together with ATP and at least one other factor, for the first cleavage-ligation reaction. Functions as a molecular motor in the activation of the precatalytic spliceosome for the first transesterification reaction of pre-mRNA splicing by hydrolyzing ATP to cause the activation of the spliceosome without the occurrence of splicing (By similarity)..
• Protein Sequence: MSLEQYVSDKAISLLGMSEPSVVEYLIAEAKGSSSSNNLYQKLVSFGMDGDDPAVKEFAHTLYARIPREGSRPKENYNARKKKEQGILQMERLNSSYDLLIEPQSHETPGKPLKKKSRSKTPKREIARRQRDEDEWESDEYEEVVDGSASHPIEEDSVSTDFQNHDYEKSSDPETERLNDLREREEFEERLRRKDLEAATNEFVEDYSSKFSSEELALRKLADDPESWRKLASELRKKSRQQYLKPRAQQQLEILRREIRDEEQLFAGEKLTQAEIRELEKKKELLRIAEERQRLEKQATEYQMPEDYFTEQGKLDRKRKEEVLYQRYKDSNEGEQNEVTMGAAEQQRWEAQQINKALLFDQNEWLPPGEKQFDFVFDESQQIDFLLDTKLSAENPVDTDKMTDVKVEKSLESSRKSLPVYQYKDDLLKAINEYQVLLIVAETGSGKTTQLPQFLHEAGYTKGNKKICCTQPRRVAAMSVAARVAKEMDVRLGQEVGYSIRFENATSEKTVIKYLTDGMLLREFLTEPDLASYSVIIIDEAHERTLHTDILFGLVKDIARFRPDLKVLISSATIDAEKFSAYFDEAPVFYVPGRRYPVDIYYTPQPEANYIQAAITTILQIHTTQPAGDILVFLTGQDEIELMSENMQELCRILGKRIPEIILCPIYANLPSELQAKIFDPTPPGARKVVLATNIAETSITIDGVNFVIDSGFVKQNMYNPRTGMESLVSVPCSRASADQRAGRAGRVGPGKCFRLYTRRTYNNELDMVTSPEIQRTNLTNIVLLLKSLGINNLLDFDFMDAPPPETLMRSLELLYALGALNNRGELTKLGRQMAEFPTDPMLSKSLIASSKYGCVEEVLSIVSMLGEASSLFYRPKDKIMEADKARANFTQPGGDHLTLLHIWNEWVDTDFSYNWARENFLQYKSLCRARDVRDQLANLCERVEIELVTNSSESLDPIKKAITAGYFSNAARLDRSGDSYRTVKSNQTVYIHPSSSVAEKKPKVIIYFELVLTTKEYCRQITEIQPEWLLEISPHYFKPENIEELQKTQKRHKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
105	Phosphorylation	DLLIEPQSHETPGKP CEEECCCCCCCCCCC	33.72	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CDC28_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CDC28_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CDC28_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CG23_SCHPO	cdc13	genetic	16049013
WEE1_SCHPO	wee1	genetic	16049013
CSK2A_SCHPO	cka1	genetic	16049013
RAD24_SCHPO	rad24	genetic	16049013

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.