CCL14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCL14_HUMAN
• UniProt AC: Q16627
• Protein Name: C-C motif chemokine 14
• Gene Name: CCL14
• Organism: Homo sapiens (Human).
• Sequence Length: 93
• Subcellular Localization: Secreted.
• Protein Description: Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5..
• Protein Sequence: MKISVAAIPFFLLITIALGTKTESSSRGPYHPSECCFTYTTYKIPRQRIMDYYETNSQCSKPGIVFITKRGHSVCTNPSDKWVQDYIKDMKEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4 (in isoform 2)	Phosphorylation	-	10.53	-
4	Phosphorylation	----MKISVAAIPFF ----CCCCHHHHHHH	10.53	-
22	Phosphorylation	TIALGTKTESSSRGP HHHHCCCCCCCCCCC	40.72	25852190
24	Phosphorylation	ALGTKTESSSRGPYH HHCCCCCCCCCCCCC	38.55	25852190
25	Phosphorylation	LGTKTESSSRGPYHP HCCCCCCCCCCCCCH	20.16	25852190
26	O-linked_Glycosylation	GTKTESSSRGPYHPS CCCCCCCCCCCCCHH	51.00	10978165
26	Phosphorylation	GTKTESSSRGPYHPS CCCCCCCCCCCCCHH	51.00	25852190
30	Phosphorylation	ESSSRGPYHPSECCF CCCCCCCCCHHHCEE	29.23	30576142
40	Phosphorylation	SECCFTYTTYKIPRQ HHCEEEEEEEEECHH	22.16	30576142
42	Phosphorylation	CCFTYTTYKIPRQRI CEEEEEEEEECHHHH	10.10	30576142
52	Phosphorylation	PRQRIMDYYETNSQC CHHHHHHHHHHCCCC	5.94	27732954
53	Phosphorylation	RQRIMDYYETNSQCS HHHHHHHHHHCCCCC	16.41	27732954
55	Phosphorylation	RIMDYYETNSQCSKP HHHHHHHHCCCCCCC	24.85	27732954
57	Phosphorylation	MDYYETNSQCSKPGI HHHHHHCCCCCCCEE	39.73	27732954
60	Phosphorylation	YETNSQCSKPGIVFI HHHCCCCCCCEEEEE	33.96	27732954
86	Phosphorylation	SDKWVQDYIKDMKEN CHHHHHHHHHHHHCC	7.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCL14_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCL14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCL14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P85A_HUMAN	PIK3R1	physical	21988832
DNLZ_HUMAN	DNLZ	physical	28514442
VWA1_HUMAN	VWA1	physical	28514442
AMZ2_HUMAN	AMZ2	physical	28514442
LRFN1_HUMAN	LRFN1	physical	28514442
PDIA5_HUMAN	PDIA5	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

O-linked Glycosylation

"Posttranslationally processed forms of the human chemokine HCC-1.";
Richter R., Schulz-Knappe P., John H., Forssmann W.-G.;
Biochemistry 39:10799-10805(2000).
Cited for: PROTEIN SEQUENCE OF 20-32, IDENTIFICATION OF HCC-1(3-74) ANDHCC-1(4-74), MASS SPECTROMETRY, AND GLYCOSYLATION AT SER-26.
PubMed: 10978165