CAN3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAN3_HUMAN
• UniProt AC: P20807
• Protein Name: Calpain-3
• Gene Name: CAPN3
• Organism: Homo sapiens (Human).
• Sequence Length: 821
• Subcellular Localization: Cytoplasm.
• Protein Description: Calcium-regulated non-lysosomal thiol-protease..
• Protein Sequence: MPTVISASVAPRTAAEPRSPGPVPHPAQSKATEAGGGNPSGIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTADALQSDKLQTWTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKLLEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEVPKEMHGNKQHLQKDFFLYNASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTISVDRPVKKKKTKPIIFVSDRANSNKELGVDQESEEGKGKTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAGDDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQKIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMFRAFHAFDKDGDGIIKLNVLEWLQLTMYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPTVISASVA -----CCCEEEEECC	29.22	21712546
6	Phosphorylation	--MPTVISASVAPRT --CCCEEEEECCCCC	15.34	24043423
8	Phosphorylation	MPTVISASVAPRTAA CCCEEEEECCCCCCC	16.42	21712546
13	Phosphorylation	SASVAPRTAAEPRSP EEECCCCCCCCCCCC	29.21	26437602
19	Phosphorylation	RTAAEPRSPGPVPHP CCCCCCCCCCCCCCC	44.94	19764811
202	O-linked_Glycosylation	NHRNEFWSALLEKAY CCCHHHHHHHHHHHH	17.85	29351928
279	Phosphorylation	MTYGTSPSGLNMGEL CCCCCCCCCCCHHHH	56.53	-
417	Phosphorylation	KLEICNLTADALQSD HHHEECCCHHHHHCC	14.43	20068231
423	Phosphorylation	LTADALQSDKLQTWT CCHHHHHCCCCCEEE	37.25	20068231
428	Phosphorylation	LQSDKLQTWTVSVNE HHCCCCCEEEEEEEC	33.27	20068231
430	Phosphorylation	SDKLQTWTVSVNEGR CCCCCEEEEEEECCC	13.29	20068231
432	Phosphorylation	KLQTWTVSVNEGRWV CCCEEEEEEECCCEE	16.32	20068231
559	Phosphorylation	SEYVIVPSTYEPHQE HHEEEECCCCCCCCC	32.50	-
581	Phosphorylation	FSEKRNLSEEVENTI HHCCCCCCHHHHHHC	34.95	30206219
587	Phosphorylation	LSEEVENTISVDRPV CCHHHHHHCCCCCCC	10.92	30206219
589	Phosphorylation	EEVENTISVDRPVKK HHHHHHCCCCCCCCC	18.87	30206219
599	Phosphorylation	RPVKKKKTKPIIFVS CCCCCCCCCCEEEEE	51.43	-
621	Phosphorylation	ELGVDQESEEGKGKT CCCCCCCCCCCCCCC	35.00	26437602
629	Phosphorylation	EEGKGKTSPDKQKQS CCCCCCCCCCCCCCC	34.29	26437602
636	Phosphorylation	SPDKQKQSPQPQPGS CCCCCCCCCCCCCCC	32.32	-
699	Phosphorylation	FTLESCRSMIALMDT CCHHHHHHHEEEECC	20.90	-
709	Phosphorylation	ALMDTDGSGKLNLQE EEECCCCCCCCCHHH	35.25	-
729	Ubiquitination	NKIKAWQKIFKHYDT HHHHHHHHHHHHCCC	39.13	-
734	Phosphorylation	WQKIFKHYDTDQSGT HHHHHHHCCCCCCCC	22.56	24043423
736	Phosphorylation	KIFKHYDTDQSGTIN HHHHHCCCCCCCCCC	28.86	24043423
739	Phosphorylation	KHYDTDQSGTINSYE HHCCCCCCCCCCHHH	40.49	24043423
741	Phosphorylation	YDTDQSGTINSYEMR CCCCCCCCCCHHHHH	23.41	24043423
744	Phosphorylation	DQSGTINSYEMRNAV CCCCCCCHHHHHHHH	20.72	24043423
745	Phosphorylation	QSGTINSYEMRNAVN CCCCCCHHHHHHHHH	14.84	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAN3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAN3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAN3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TITIN_HUMAN	TTN	physical	9642272
NECA2_HUMAN	NECAB2	physical	16189514
FLNC_HUMAN	FLNC	physical	14506720
TITIN_HUMAN	TTN	physical	8537379
OSGI1_HUMAN	OSGIN1	physical	25416956
NTAQ1_HUMAN	WDYHV1	physical	25416956
SYYM_HUMAN	YARS2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 253600: Limb-girdle muscular dystrophy 2A (LGMD2A)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.