CAD23_HUMAN - dbPTM
CAD23_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CAD23_HUMAN
UniProt AC Q9H251
Protein Name Cadherin-23 {ECO:0000303|PubMed:11138009}
Gene Name CDH23 {ECO:0000303|PubMed:11138009, ECO:0000312|HGNC:HGNC:13733}
Organism Homo sapiens (Human).
Sequence Length 3354
Subcellular Localization Cell membrane
Single-pass type I membrane protein .
Protein Description Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing..
Protein Sequence MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFEEEFIHLLSNITGAIVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVDRVIQMIDENKEQLRNLFRNYNVLDVQPAISVRLPDDMSALQMAIIVLAILLFLAAMLFVLMNWYYRTVHKRKLKAIVAGSAGNRGFIDIMDMPNTNKYSFDGANPVWLDPFCRNLELAAQAEHEDDLPENLSEIADLWNSPTRTHGTFGREPAAVKPDDDRYLRAAIQEYDNIAKLGQIIREGPIKGSLLKVVLEDYLRLKKLFAQRMVQKASSCHSSISELIQTELDEEPGDHSPGQGSLRFRHKPPVELKGPDGIHVVHGSTGTLLATDLNSLPEEDQKGLGRSLETLTAAEATAFERNARTESAKSTPLHKLRDVIMETPLEITEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MGRHVATSCHVAWL
-CCCCHHHHHHHHHH		30.6924043423
8PhosphorylationMGRHVATSCHVAWLL
CCCCHHHHHHHHHHH		7.7824043423
19PhosphorylationAWLLVLISGCWGQVN
HHHHHHHHCCCCHHH		24.6024043423
155N-linked_GlycosylationGTPIFIVNATDPDLG
CCCEEEEECCCCCCC		32.10UniProtKB CARBOHYD
201PhosphorylationDYETTQAYQLTVNAT
CCCCCEEEEEEECCC		8.34-
206N-linked_GlycosylationQAYQLTVNATDQDKT
EEEEEEECCCCCCCC		31.71UniProtKB CARBOHYD
208PhosphorylationYQLTVNATDQDKTRP
EEEEECCCCCCCCCC		29.05-
213PhosphorylationNATDQDKTRPLSTLA
CCCCCCCCCCHHHHH		45.89-
349N-linked_GlycosylationNDNAPEFNSSEYSVA
CCCCCCCCCCCHHHH		42.86UniProtKB CARBOHYD
393N-linked_GlycosylationFEVYLVGNNSHHFII
EEEEEECCCCCEEEE		39.07UniProtKB CARBOHYD
434N-linked_GlycosylationYDFDLFANESVPDHV
CCEEECCCCCCCCCC		34.44UniProtKB CARBOHYD
461 (in isoform 5)Phosphorylation-31.4424043423
465 (in isoform 5)Phosphorylation-19.6824043423
466N-linked_GlycosylationIFSQPLYNISLYENV
CCCCCCEEEEEECCC		25.67UniProtKB CARBOHYD
468 (in isoform 5)Phosphorylation-22.6624043423
470 (in isoform 5)Phosphorylation-9.9224043423
472N-linked_GlycosylationYNISLYENVTVGTSV
EEEEEECCCEECCEE		22.62UniProtKB CARBOHYD
474 (in isoform 5)Phosphorylation-25.4624043423
477 (in isoform 5)Phosphorylation-16.0124043423
478 (in isoform 5)Phosphorylation-14.8124043423
481 (in isoform 5)Phosphorylation-16.0024043423
485 (in isoform 5)Phosphorylation-31.0424043423
489 (in isoform 5)Phosphorylation-25.77-
523PhosphorylationMLIARLDYELIQRFT
HHHEECCHHHHHHEE		19.75-
622PhosphorylationYEGYGVISVSRPLDY
EECCCEEEECCCCCH		16.1924719451
652N-linked_GlycosylationDAGNPPLNSTVPVTI
CCCCCCCCCCCCEEE		41.21UniProtKB CARBOHYD
694N-linked_GlycosylationGATVLFLNATDLDRS
CCEEEEEECCCCHHH		33.20UniProtKB CARBOHYD
704PhosphorylationDLDRSREYGQESIIY
CCHHHHHHCCEEEEE		24.01-
711PhosphorylationYGQESIIYSLEGSTQ
HCCEEEEEEEECCEE		12.92-
742PhosphorylationDRETKSEYILIVRAV
CCCCCCCEEEEEEEC		14.2324260401
765N-linked_GlycosylationKTGIATVNITLLDIN
CCCEEEEEEEEEECC		19.71UniProtKB CARBOHYD
810N-linked_GlycosylationVDPDLGENGTLVYSI
ECCCCCCCCEEEEEE		47.12UniProtKB CARBOHYD
827N-linked_GlycosylationPNKFYSLNSTTGKIR
CCCEEECCCCCCCEE		31.22UniProtKB CARBOHYD
941N-linked_GlycosylationPRMDFLINSSSGVVV
CCCEEEEECCCCEEE		37.68UniProtKB CARBOHYD
943PhosphorylationMDFLINSSSGVVVTT
CEEEEECCCCEEEEC		26.9921712546
951PhosphorylationSGVVVTTTELDRERI
CCEEEECCCCCHHHH		25.7821712546
1001N-linked_GlycosylationTFFPAVYNVSVSEDV
CCCCEEEEEECCCCC		17.00UniProtKB CARBOHYD
1018N-linked_GlycosylationEFRVVWLNCTDNDVG
CEEEEEEECCCCCCC		15.78UniProtKB CARBOHYD
1171N-linked_GlycosylationRPLDRERNSSHVLIV
CCCCCCCCCCCEEEE		43.01UniProtKB CARBOHYD
1172PhosphorylationPLDRERNSSHVLIVE
CCCCCCCCCCEEEEE		28.2130206219
1173PhosphorylationLDRERNSSHVLIVEA
CCCCCCCCCEEEEEE		22.5930206219
1181PhosphorylationHVLIVEAYNHDLGPM
CEEEEEEECCCCCCC		10.2630206219
1226PhosphorylationRETAGIGTSVIVVQA
HHCCCCCCEEEEEEE		20.2129507054
1227PhosphorylationETAGIGTSVIVVQAT
HCCCCCCEEEEEEEC		12.4829507054
1234PhosphorylationSVIVVQATDRDSGDG
EEEEEEECCCCCCCC		17.9329507054
1246PhosphorylationGDGGLVNYRILSGAE
CCCCEEEEEEEECCC		7.49-
1267PhosphorylationESTGLIITVNYLDYE
CCCCEEEEEEEECCC		8.8425332170
1270PhosphorylationGLIITVNYLDYETKT
CEEEEEEEECCCCCC		9.1625332170
1282N-linked_GlycosylationTKTSYMMNVSATDQA
CCCCEECCCCCCCCC		14.20UniProtKB CARBOHYD
1315N-linked_GlycosylationDEAVQFSNASYEAAI
HHHHHCCCCCHHHHH		33.91UniProtKB CARBOHYD
1473N-linked_GlycosylationAFEIVTTNDSIGEVF
EEEEEECCCCCCEEE		31.50UniProtKB CARBOHYD
1534N-linked_GlycosylationIESPFGYNVSVNENV
EECCCCEEEEECCCC		21.70UniProtKB CARBOHYD
1582PhosphorylationAFRMDRISGEIATRP
EEEEECCCCEEECCC		31.1323403867
1587PhosphorylationRISGEIATRPAPPDR
CCCCEEECCCCCCCH		42.7323403867
1651N-linked_GlycosylationDEGPDTLNTSLITIQ
CCCCCCCCCEEEEEE		29.70UniProtKB CARBOHYD
1667N-linked_GlycosylationLDLDEGPNGTVTYAI
EECCCCCCCEEEEEE		70.40UniProtKB CARBOHYD
1672PhosphorylationGPNGTVTYAIVAGNI
CCCCEEEEEEEECCE		7.04-
1725PhosphorylationPILSHRLTSTTTVLV
CCCCEECCCCEEEEE		24.8024275569
1726PhosphorylationILSHRLTSTTTVLVN
CCCEECCCCEEEEEE		28.4824275569
1729PhosphorylationHRLTSTTTVLVNVND
EECCCCEEEEEEHHH		16.3624275569
1743PhosphorylationDINDNVPTFPRDYEG
HCCCCCCCCCCCCCC		41.8224275569
1818N-linked_GlycosylationRETIAFYNLTICARD
HHEEEEEEEEEEEHH		25.01UniProtKB CARBOHYD
1857N-linked_GlycosylationVLLNLPMNITISENS
EEECCCCEEEECCCC		26.72UniProtKB CARBOHYD
1889N-linked_GlycosylationCNARLTFNITAGNRE
CCEEEEEEECCCCCE		26.01UniProtKB CARBOHYD
1902N-linked_GlycosylationRERAFFINATTGIVT
CEEEEEEECCCCEEE		26.52UniProtKB CARBOHYD
2013N-linked_GlycosylationQSGLFDINSSTGVVT
CCCCEECCCCCCEEE		31.58UniProtKB CARBOHYD
2050N-linked_GlycosylationAEDIGLLNSTAHLLI
HHHHCCCCCCEEEEE		42.21UniProtKB CARBOHYD
2129N-linked_GlycosylationTGVIRVGNATIDREE
HCEEEECCEEECHHH		30.93UniProtKB CARBOHYD
2168N-linked_GlycosylationTILIDDINDSRPEFL
EEEEECCCCCCCHHC		48.47UniProtKB CARBOHYD
2195N-linked_GlycosylationEPGTVIANITAIDHD
CCCCEEEEEEEECCC		22.48UniProtKB CARBOHYD
2220PhosphorylationGIVAKDDTDRLVPNQ
EEEECCCCCCCCCCC		32.9024719451
2237PhosphorylationAFAVNINTGSVMVKS
CEEEECCCCCEEEEC		27.3424719451
2239PhosphorylationAVNINTGSVMVKSPM
EEECCCCCEEEECCC		12.6624719451
2259PhosphorylationATYEVTLSVIDNASD
EEEEEEEEEECCHHH		13.9920736484
2263N-linked_GlycosylationVTLSVIDNASDLPER
EEEEEECCHHHCCCC		30.16UniProtKB CARBOHYD
2271PhosphorylationASDLPERSVSVPNAK
HHHCCCCCCCCCCCE		19.6520736484
2280PhosphorylationSVPNAKLTVNVLDVN
CCCCCEEEEEEEECC		14.88-
2290PhosphorylationVLDVNDNTPQFKPFG
EEECCCCCCCCCCCC		22.72-
2357N-linked_GlycosylationSAGKVIANRTVDYEE
CCCCEEEECEECCCE		29.09UniProtKB CARBOHYD
2369N-linked_GlycosylationYEEVHWLNFTVRASD
CCEEEEEEEEEEECC		25.92UniProtKB CARBOHYD
2379PhosphorylationVRASDNGSPPRAAEI
EEECCCCCCCCCCCC		37.6828258704
2562PhosphorylationAFHVDMDSGLVTTQR
EEEEECCCCCEECCC		27.65-
2616N-linked_GlycosylationPVFVRPPNGTILHIR
CEEEECCCCCEEEEE		64.02UniProtKB CARBOHYD
2633PhosphorylationIPLRSNVYEVYATDK
CCCCCCEEEEEEECC		12.15-
2636PhosphorylationRSNVYEVYATDKDEG
CCCEEEEEEECCCCC		7.58-
2650PhosphorylationGLNGAVRYSFLKTAG
CCCCEEEEEEEEECC		9.36-
2651PhosphorylationLNGAVRYSFLKTAGN
CCCEEEEEEEEECCC		17.3424719451
2729PhosphorylationFVRPPKGSPQYQLLT
EECCCCCCCCEEEEE		18.24-
2732PhosphorylationPPKGSPQYQLLTVPE
CCCCCCCEEEEECCC		12.43-
2736PhosphorylationSPQYQLLTVPEHSPR
CCCEEEEECCCCCCC		42.48-
2741PhosphorylationLLTVPEHSPRGTLVG
EEECCCCCCCCEEEE		18.03-
2749N-linked_GlycosylationPRGTLVGNVTGAVDA
CCCEEEEEEEECCCC		22.24UniProtKB CARBOHYD
2806PhosphorylationFSFIVKASSNRSWTP
EEEEEECCCCCCCCC		23.5623898821
2807PhosphorylationSFIVKASSNRSWTPP
EEEEECCCCCCCCCC		40.9123911959
2808N-linked_GlycosylationFIVKASSNRSWTPPR
EEEECCCCCCCCCCC		39.24UniProtKB CARBOHYD
2810PhosphorylationVKASSNRSWTPPRGP
EECCCCCCCCCCCCC		39.2823911959
2812PhosphorylationASSNRSWTPPRGPSP
CCCCCCCCCCCCCCC		25.3523911959
2877N-linked_GlycosylationALDADIGNNSLVFYS
EEECCCCCCHHHHHH		34.94UniProtKB CARBOHYD
2896N-linked_GlycosylationHYFRALANDSEDVGQ
HHHHHHCCCCCCHHC		54.94UniProtKB CARBOHYD
2941N-linked_GlycosylationARDLAGHNDTAIIGI
HHHHCCCCCCEEEEE		47.62UniProtKB CARBOHYD
2943PhosphorylationDLAGHNDTAIIGIYI
HHCCCCCCEEEEEEE		25.6924719451
2949PhosphorylationDTAIIGIYILRDDQR
CCEEEEEEEEECCCE		6.6824719451
2981N-linked_GlycosylationEFIHLLSNITGAIVN
HHHHHHHHCCCEEEE		35.49UniProtKB CARBOHYD
3063PhosphorylationVRLPDDMSALQMAII
ECCCCCCHHHHHHHH		32.5924043423
3089PhosphorylationLFVLMNWYYRTVHKR
HHHHHHHHHHHHHHH		4.3224043423
3090PhosphorylationFVLMNWYYRTVHKRK
HHHHHHHHHHHHHHC		7.4524043423
3105PhosphorylationLKAIVAGSAGNRGFI
CHHHEECCCCCCCCE		24.2225247763
3181UbiquitinationGREPAAVKPDDDRYL
CCCCCCCCCCCHHHH		37.69-
3195PhosphorylationLRAAIQEYDNIAKLG
HHHHHHHHHHHHHHH		9.6419060867
3213PhosphorylationREGPIKGSLLKVVLE
HHCCCCCHHHHHHHH		26.0624719451
3222PhosphorylationLKVVLEDYLRLKKLF
HHHHHHHHHHHHHHH		5.5924732914
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CAD23_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CAD23_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CAD23_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
USH1C_HUMANUSH1Cphysical
12485990
USH1C_HUMANUSH1Cphysical
12407180
GOPC_HUMANGOPCphysical
27173435
NCKP1_HUMANNCKAP1physical
27173435
ABI1_HUMANABI1physical
27173435
NXN_HUMANNXNphysical
27173435
CYFP1_HUMANCYFIP1physical
27173435
NHRF2_HUMANSLC9A3R2physical
27173435
Drug and Disease Associations
Kegg Disease
H00605 Deafness, autosomal recessive
H00779 Usher syndrome (US)
OMIM Disease
601067Usher syndrome 1D (USH1D)
601067Usher syndrome 1D/F (USH1DF)
601386Deafness, autosomal recessive, 12 (DFNB12)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CAD23_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-3195, AND MASSSPECTROMETRY.

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