C2AIL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: C2AIL_HUMAN
• UniProt AC: Q96HQ2
• Protein Name: CDKN2AIP N-terminal-like protein
• Gene Name: CDKN2AIPNL
• Organism: Homo sapiens (Human).
• Sequence Length: 116
• Protein Sequence: MVGGEAAAAVEELVSGVRQAADFAEQFRSYSESEKQWKARMEFILRHLPDYRDPPDGSGRLDQLLSLSMVWANHLFLGCSYNKDLLDKVMEMADGIEVEDLPQFTTRSELMKKHQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MVGGEAAA -------CCCHHHHH	5.96	22814378
15	Phosphorylation	AAVEELVSGVRQAAD HHHHHHHHHHHHHHH	44.17	27251275
35	2-Hydroxyisobutyrylation	RSYSESEKQWKARME HCCCHHHHHHHHHHH	71.40	-
35	Ubiquitination	RSYSESEKQWKARME HCCCHHHHHHHHHHH	71.40	29967540
38	Ubiquitination	SESEKQWKARMEFIL CHHHHHHHHHHHHHH	24.50	-
41	Sulfoxidation	EKQWKARMEFILRHL HHHHHHHHHHHHHHC	6.19	21406390
66 (in isoform 2)	Phosphorylation	-	27.30	24043423
68 (in isoform 2)	Phosphorylation	-	14.12	24043423
80	Phosphorylation	NHLFLGCSYNKDLLD HHHHHCCCCCHHHHH	29.91	27050516
80 (in isoform 2)	Phosphorylation	-	29.91	24043423
112	Ubiquitination	TTRSELMKKHQS--- CCHHHHHHHHCC---	60.78	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of C2AIL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of C2AIL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of C2AIL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAF12_HUMAN	TAF12	physical	26496610
BCLF1_HUMAN	BCLAF1	physical	26496610
SC16A_HUMAN	SEC16A	physical	26496610
XRN2_HUMAN	XRN2	physical	26496610
WAC_HUMAN	WAC	physical	26496610
NCK5L_HUMAN	NCKAP5L	physical	26496610
PSRC1_HUMAN	PSRC1	physical	26496610
PKHA8_HUMAN	PLEKHA8	physical	26496610
CHAP1_HUMAN	CHAMP1	physical	26496610

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.
PubMed: 19413330