BICC_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BICC_DROME
• UniProt AC: Q24009
• Protein Name: Protein bicaudal C
• Gene Name: BicC
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 905
• Protein Description: RNA-binding protein that is involved in oogenesis. Required for correct targeting of the migrating anterior follicle cells and the establishment of anterior-posterior polarity in the oocyte. May act as translational repressor of oskar during oogenesis. Function seems to be sensitive to small changes in expression..
• Protein Sequence: MLSCASFNKLMYPSAADVAKPPMVGLEVEAGSIGSLSSLHALPSTTSVGSGAPSETQSEISSVDSDWSDIRAIAMKLGVQNPDDLHTERFKVDRQKLEQLIKAESSIEGMNGAEYFFHDIMNTTDTYVSWPCRLKIGAKSKKDPHVRIVGKVDQVQRAKERILSSLDSRGTRVIMKMDVSYTDHSYIIGRGGNNIKRIMDDTHTHIHFPDSNRSNPTEKSNQVSLCGSLEGVERARALVRLSTPLLISFEMPVMGPNKPQPDHETPYIKMIETKFNVQVIFSTRPKLHTSLVLVKGSEKESAQVRDATQLLINFACESIASQILVNVQMEISPQHHEIVKGKNNVNLLSIMERTQTKIIFPDLSDMNVKPLKKSQVTISGRIDDVYLARQQLLGNLPVALIFDFPDNHNDASEIMSLNTKYGVYITLRQKQRQSTLAIVVKGVEKFIDKIYEARQEILRLATPFVKPEIPDYYFMPKDKDLNLAYRTQLTALLAGYVDSPKTPSLLPPSLAGQLTPYANNNHLLLNANGLATPTGVCAPTQKYMQLHNSFQQAQNRSMVAGGQSNNGNYLQVPGAVAPPLKPPTVSPRNSCSQNTSGYQSFSSSTTSLEQSYPPYAQLPGTVSSTSSSTAGSQNRAHYSPDSTYGSEGGGVGGGGGGGARLGRRLSDGVLLGLSNSNGGGGNSGGAHLLPGSAESYRSLHYDLGGNKHSGHRAFDFDMKRALGYKAMERTPVAGELRTPTTAWMGMGLSSTSPAPAPLENGENGAAGGGASSGWRLPPGLGSPYGLSATTGLLDATPVNRRMQLAKHKDIQTLLTSLGLEHYIKIFVLNEIDLEVFTTLTEENLMELGIAAFGARKKLLTAIHTLLANEAACSTMPSSSSSQNSSSPRFSGSAAPGAERRPSNQW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
549	Phosphorylation	KYMQLHNSFQQAQNR HHHHHHHHHHHHHHH	17.43	22817900
557	Phosphorylation	FQQAQNRSMVAGGQS HHHHHHHHHCCCCCC	25.76	22817900
584	Phosphorylation	APPLKPPTVSPRNSC CCCCCCCCCCCCCCC	41.99	30478224
586	Phosphorylation	PLKPPTVSPRNSCSQ CCCCCCCCCCCCCCC	22.18	22817900
639	Phosphorylation	SQNRAHYSPDSTYGS CCCCCCCCCCCCCCC	16.62	22817900
642	Phosphorylation	RAHYSPDSTYGSEGG CCCCCCCCCCCCCCC	27.23	30478224
643	Phosphorylation	AHYSPDSTYGSEGGG CCCCCCCCCCCCCCC	39.00	18327897
644	Phosphorylation	HYSPDSTYGSEGGGV CCCCCCCCCCCCCCC	23.70	18327897
646	Phosphorylation	SPDSTYGSEGGGVGG CCCCCCCCCCCCCCC	23.74	18327897
666	Phosphorylation	ARLGRRLSDGVLLGL CCCCCCCCCCEEEEC	30.43	22817900
692	Phosphorylation	GAHLLPGSAESYRSL CCCCCCCCHHHHHCE	27.24	22817900
695	Phosphorylation	LLPGSAESYRSLHYD CCCCCHHHHHCEEEE	26.09	22817900
696	Phosphorylation	LPGSAESYRSLHYDL CCCCHHHHHCEEEEC	8.84	9671494
782	Phosphorylation	RLPPGLGSPYGLSAT CCCCCCCCCCCCCCC	21.71	30478224
796	Phosphorylation	TTGLLDATPVNRRMQ CCCCCCCCCCCHHHH	27.69	30478224

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BICC_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BICC_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BICC_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VND_DROME	vnd	physical	14605208
DDX6_DROME	me31B	genetic	19217894
EXU_DROME	exu	genetic	19217894
GRK_DROME	grk	physical	23213441
BICC_DROME	BicC	physical	17981137

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-557; SER-586; SER-639;SER-642; THR-643; TYR-644; SER-646; SER-666; SER-692; SER-695 ANDTYR-696, AND MASS SPECTROMETRY.
PubMed: 18327897