ARFA_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARFA_ARATH
• UniProt AC: Q8L7G0
• Protein Name: Auxin response factor 1
• Gene Name: ARF1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 665
• Subcellular Localization: Nucleus.
• Protein Description: Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs). Seems to act as transcriptional repressor. Formation of heterodimers with Aux/IAA proteins may alter their ability to modulate early auxin response genes expression. Promotes flowering, stamen development, floral organ abscission and fruit dehiscence. Acts as repressor of IAA2, IAA3 and IAA7..
• Protein Sequence: MAASNHSSGKPGGVLSDALCRELWHACAGPLVTLPREGERVYYFPEGHMEQLEASMHQGLEQQMPSFNLPSKILCKVINIQRRAEPETDEVYAQITLLPELDQSEPTSPDAPVQEPEKCTVHSFCKTLTASDTSTHGGFSVLRRHADDCLPPLDMSQQPPWQELVATDLHNSEWHFRHIFRGQPRRHLLTTGWSVFVSSKKLVAGDAFIFLRGENEELRVGVRRHMRQQTNIPSSVISSHSMHIGVLATAAHAITTGTIFSVFYKPRTSRSEFIVSVNRYLEAKTQKLSVGMRFKMRFEGEEAPEKRFSGTIVGVQENKSSVWHDSEWRSLKVQWDEPSSVFRPERVSPWELEPLVANSTPSSQPQPPQRNKRPRPPGLPSPATGPSGPVTPDGVWKSPADTPSSVPLFSPPAKAATFGHGGNKSFGVSIGSAFWPTNADSAAESFASAFNNESTEKKQTNGNVCRLFGFELVENVNVDECFSAASVSGAVAVDQPVPSNEFDSGQQSEPLNINQSDIPSGSGDPEKSSLRSPQESQSRQIRSCTKVHMQGSAVGRAIDLTRSECYEDLFKKLEEMFDIKGELLESTKKWQVVYTDDEDDMMMVGDDPWNEFCGMVRKIFIYTPEEVKKLSPKNKLAVNARMQLKADAEENGNTEGRSSSMAGSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
410	Phosphorylation	PSSVPLFSPPAKAAT CCCCCCCCCCCCCCC	37.34	23111157
532	Phosphorylation	PEKSSLRSPQESQSR CCHHCCCCCCHHHHH	35.91	29654922

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARFA_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARFA_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARFA_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARFA_ARATH	ARF1	physical	22096563
ARFR_ARATH	ARF18	physical	22096563
ARFA_ARATH	ARF1	physical	24485461
IAA17_ARATH	AXR3	physical	25566309
IAA18_ARATH	IAA18	physical	25566309
IAA32_ARATH	IAA32	physical	25566309
IAA34_ARATH	IAA34	physical	25566309

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.