AREG_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AREG_HUMAN
• UniProt AC: P15514
• Protein Name: Amphiregulin {ECO:0000303|PubMed:2325643}
• Gene Name: AREG {ECO:0000312|HGNC:HGNC:651}
• Organism: Homo sapiens (Human).
• Sequence Length: 252
• Subcellular Localization: Membrane; Single-pass membrane protein.
• Protein Description: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts..
• Protein Sequence: MRAPLLPPAPVVLSLLILGSGHYAAGLDLNDTYSGKREPFSGDHSADGFEVTSRSEMSSGSEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENTSDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKKLRQENGNVHAIA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	N-linked_Glycosylation	YAAGLDLNDTYSGKR CEECCCCCCCCCCCC	38.96	UniProtKB CARBOHYD
41	O-linked_Glycosylation	SGKREPFSGDHSADG CCCCCCCCCCCCCCC	54.77	55824753
52	O-linked_Glycosylation	SADGFEVTSRSEMSS CCCCEEECCHHHCCC	15.95	55824759
53	O-linked_Glycosylation	ADGFEVTSRSEMSSG CCCEEECCHHHCCCC	38.70	55824763
109	Ubiquitination	VRVEQVVKPPQNKTE CEEEEEECCCCCCCC	52.72	21906983
113	N-linked_Glycosylation	QVVKPPQNKTESENT EEECCCCCCCCCCCC	60.02	UniProtKB CARBOHYD
114	Ubiquitination	VVKPPQNKTESENTS EECCCCCCCCCCCCC	48.71	22817900
117	Phosphorylation	PPQNKTESENTSDKP CCCCCCCCCCCCCCC	41.18	-
119	N-linked_Glycosylation	QNKTESENTSDKPKR CCCCCCCCCCCCCCH	54.91	UniProtKB CARBOHYD
128	Ubiquitination	SDKPKRKKKGGKNGK CCCCCHHCCCCCCCC	61.76	-
129	Ubiquitination	DKPKRKKKGGKNGKN CCCCHHCCCCCCCCC	75.76	-
169	O-linked_Glycosylation	IEHLEAVTCKCQQEY HHHHEEEECCCCHHH	17.19	55830075
184	Ubiquitination	FGERCGEKSMKTHSM HHHHCCCHHHHHHHH	40.93	23503661
187	Ubiquitination	RCGEKSMKTHSMIDS HCCCHHHHHHHHCHH	50.61	27667366
194	Phosphorylation	KTHSMIDSSLSKIAL HHHHHCHHHHHHHHH	23.43	-
230	Acetylation	LRRQYVRKYEGEAEE HHHHHHHHHCCCHHH	37.29	7483917
230	Ubiquitination	LRRQYVRKYEGEAEE HHHHHHHHHCCCHHH	37.29	21906983
231	Phosphorylation	RRQYVRKYEGEAEER HHHHHHHHCCCHHHH	20.71	19664994
239	Acetylation	EGEAEERKKLRQENG CCCHHHHHHHHHHHC	60.48	7483925
240	Acetylation	GEAEERKKLRQENGN CCHHHHHHHHHHHCC	55.94	7483933
240	Ubiquitination	GEAEERKKLRQENGN CCHHHHHHHHHHHCC	55.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AREG_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AREG_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AREG_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
KR103_HUMAN	KRTAP10-3	physical	25416956
ADCY9_HUMAN	ADCY9	physical	26186194
ICAM1_HUMAN	ICAM1	physical	26186194
AREG_HUMAN	AREG	physical	26186194
NEUL4_HUMAN	NEURL4	physical	26186194
AREG_HUMAN	AREG	physical	28514442
ADCY9_HUMAN	ADCY9	physical	28514442
ICAM1_HUMAN	ICAM1	physical	28514442
SNX11_HUMAN	SNX11	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.