ANXA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANXA3_HUMAN
• UniProt AC: P12429
• Protein Name: Annexin A3
• Gene Name: ANXA3
• Organism: Homo sapiens (Human).
• Sequence Length: 323
• Protein Description: Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate..
• Protein Sequence: MASIWVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNAQRQLIVKEYQAAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKKSLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGENRWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLLLAIVNCVRNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLYSAIKSDTSGDYEITLLKICGGDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASIWVGHR ------CCCEEECCC	15.10	-
11	Phosphorylation	IWVGHRGTVRDYPDF EEECCCCCCCCCCCC	16.60	28152594
15	Phosphorylation	HRGTVRDYPDFSPSV CCCCCCCCCCCCCCC	8.30	28152594
19	Phosphorylation	VRDYPDFSPSVDAEA CCCCCCCCCCCCHHH	24.52	25159151
21	Phosphorylation	DYPDFSPSVDAEAIQ CCCCCCCCCCHHHHH	31.28	28450419
29	Acetylation	VDAEAIQKAIRGIGT CCHHHHHHHHHCCCC	39.40	23954790
29	Ubiquitination	VDAEAIQKAIRGIGT CCHHHHHHHHHCCCC	39.40	21906983
58	Acetylation	AQRQLIVKEYQAAYG HHHHHHHHHHHHHHC	43.65	23954790
58	Ubiquitination	AQRQLIVKEYQAAYG HHHHHHHHHHHHHHC	43.65	22817900
58	Succinylation	AQRQLIVKEYQAAYG HHHHHHHHHHHHHHC	43.65	23954790
66	Ubiquitination	EYQAAYGKELKDDLK HHHHHHCHHHHHHHC	47.39	27667366
89	Phosphorylation	HLMVALVTPPAVFDA HHHHHHHCCCCCCCH	25.14	110740895
97	Acetylation	PPAVFDAKQLKKSMK CCCCCCHHHHHHHHC	58.99	23954790
100	Ubiquitination	VFDAKQLKKSMKGAG CCCHHHHHHHHCCCC	40.06	22817900
101	Ubiquitination	FDAKQLKKSMKGAGT CCHHHHHHHHCCCCC	65.46	22817900
104	Methylation	KQLKKSMKGAGTNED HHHHHHHCCCCCCHH	53.34	-
104	Ubiquitination	KQLKKSMKGAGTNED HHHHHHHCCCCCCHH	53.34	21906983
121	Phosphorylation	IEILTTRTSRQMKDI HHHHHHCCHHHHHCH	26.60	24719451
122	Phosphorylation	EILTTRTSRQMKDIS HHHHHCCHHHHHCHH	19.75	24719451
129	Phosphorylation	SRQMKDISQAYYTVY HHHHHCHHHHHHHHH	20.92	26074081
132	Phosphorylation	MKDISQAYYTVYKKS HHCHHHHHHHHHHHH	7.64	28152594
133	Phosphorylation	KDISQAYYTVYKKSL HCHHHHHHHHHHHHH	7.86	26074081
134	Phosphorylation	DISQAYYTVYKKSLG CHHHHHHHHHHHHHC	12.51	26074081
136	Phosphorylation	SQAYYTVYKKSLGDD HHHHHHHHHHHHCCC	12.61	26074081
137	Acetylation	QAYYTVYKKSLGDDI HHHHHHHHHHHCCCC	31.39	26051181
137	Succinylation	QAYYTVYKKSLGDDI HHHHHHHHHHHCCCC	31.39	23954790
138	Ubiquitination	AYYTVYKKSLGDDIS HHHHHHHHHHCCCCC	32.97	29967540
139	Phosphorylation	YYTVYKKSLGDDISS HHHHHHHHHCCCCCC	33.17	28985074
145	Phosphorylation	KSLGDDISSETSGDF HHHCCCCCCCCCHHH	29.17	25159151
146	Phosphorylation	SLGDDISSETSGDFR HHCCCCCCCCCHHHH	45.27	25159151
148	Phosphorylation	GDDISSETSGDFRKA CCCCCCCCCHHHHHH	39.70	110740911
149	Phosphorylation	DDISSETSGDFRKAL CCCCCCCCHHHHHHH	32.11	25159151
154	Ubiquitination	ETSGDFRKALLTLAD CCCHHHHHHHHHHHC	43.30	29967540
167	Phosphorylation	ADGRRDESLKVDEHL HCCCCCCCCCCCHHH	37.47	20873877
169	Ubiquitination	GRRDESLKVDEHLAK CCCCCCCCCCHHHHH	57.85	33845483
169	Acetylation	GRRDESLKVDEHLAK CCCCCCCCCCHHHHH	57.85	26051181
176	Succinylation	KVDEHLAKQDAQILY CCCHHHHHHHHHHHH	55.88	23954790
176	Ubiquitination	KVDEHLAKQDAQILY CCCHHHHHHHHHHHH	55.88	27667366
183	Phosphorylation	KQDAQILYKAGENRW HHHHHHHHHCCCCCC	10.62	27273156
184	Ubiquitination	QDAQILYKAGENRWG HHHHHHHHCCCCCCC	46.61	21906983
196	Ubiquitination	RWGTDEDKFTEILCL CCCCCHHHHHHHHHH	52.73	29967540
210	Ubiquitination	LRSFPQLKLTFDEYR HHCCCCCEEEHHHHC	39.99	23000965
216	Phosphorylation	LKLTFDEYRNISQKD CEEEHHHHCCCCHHH	15.71	110740919
222	Ubiquitination	EYRNISQKDIVDSIK HHCCCCHHHHHHHHC	42.50	27667366
222	Acetylation	EYRNISQKDIVDSIK HHCCCCHHHHHHHHC	42.50	23954790
222	Succinylation	EYRNISQKDIVDSIK HHCCCCHHHHHHHHC	42.50	23954790
233	Phosphorylation	DSIKGELSGHFEDLL HHHCHHHCHHHHHHH	26.39	28348404
263	Acetylation	ERLHRALKGIGTDEF HHHHHHHCCCCCCCH	47.71	25825284
263	Ubiquitination	ERLHRALKGIGTDEF HHHHHHHCCCCCCCH	47.71	27667366
267	Phosphorylation	RALKGIGTDEFTLNR HHHCCCCCCCHHHHC	30.36	-
271	Phosphorylation	GIGTDEFTLNRIMVS CCCCCCHHHHCCCCC	22.52	27050516
280	Phosphorylation	NRIMVSRSEIDLLDI HCCCCCHHHCEEHHH	31.25	21712546
295	Phosphorylation	RTEFKKHYGYSLYSA HHHHHHHHCCCHHHH	27.00	28152594
297	Phosphorylation	EFKKHYGYSLYSAIK HHHHHHCCCHHHHHH	6.58	28152594
298	Phosphorylation	FKKHYGYSLYSAIKS HHHHHCCCHHHHHHC	19.23	28152594
300	Phosphorylation	KHYGYSLYSAIKSDT HHHCCCHHHHHHCCC	7.07	27273156
301	Phosphorylation	HYGYSLYSAIKSDTS HHCCCHHHHHHCCCC	28.89	30815365
307	Phosphorylation	YSAIKSDTSGDYEIT HHHHHCCCCCCEEEE	41.52	28152594
308	Phosphorylation	SAIKSDTSGDYEITL HHHHCCCCCCEEEEE	34.36	28152594
311	Phosphorylation	KSDTSGDYEITLLKI HCCCCCCEEEEEEEE	16.86	28152594
314	Phosphorylation	TSGDYEITLLKICGG CCCCEEEEEEEECCC	17.69	28152594

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANXA3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANXA3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANXA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IGS21_HUMAN	IGSF21	physical	16169070
P53_HUMAN	TP53	physical	16169070
UBR1_HUMAN	UBR1	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
STX4_HUMAN	STX4	physical	22939629
STXB2_HUMAN	STXBP2	physical	22939629
ANXA4_HUMAN	ANXA4	physical	22939629
SNP23_HUMAN	SNAP23	physical	22939629
SSNA1_HUMAN	SSNA1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.