AL8A1_HUMAN - dbPTM
AL8A1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AL8A1_HUMAN
UniProt AC Q9H2A2
Protein Name Aldehyde dehydrogenase family 8 member A1
Gene Name ALDH8A1
Organism Homo sapiens (Human).
Sequence Length 487
Subcellular Localization Cytoplasm.
Protein Description Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro)..
Protein Sequence MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVKH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23PhosphorylationGKFLPCSSYIDSYDP
CCEEECHHHCCEECC		32.5924275569
60PhosphorylationAAREAFPSWSSRSPQ
HHHHHCCCCCCCCHH		32.8923403867
62PhosphorylationREAFPSWSSRSPQER
HHHCCCCCCCCHHHH		21.8823403867
63PhosphorylationEAFPSWSSRSPQERS
HHCCCCCCCCHHHHH		30.4423403867
83PhosphorylationVADLLEQSLEEFAQA
HHHHHHHHHHHHHHH		28.5135081923
92PhosphorylationEEFAQAESKDQGKTL
HHHHHHHCHHHHHHH		44.5435081919
235PhosphorylationSFTGSQPTAERITQL
EEECCCCCHHHHHHH		33.2546162119
247S-nitrosylationTQLSAPHCKKLSLEL
HHHCCHHHCEEEHHH		3.9624105792
251PhosphorylationAPHCKKLSLELGGKN
CHHHCEEEHHHCCCC		28.7728857561
278PhosphorylationCIPATVRSSFANQGE
HCCHHHHHHCCCCCC		26.0228857561
279PhosphorylationIPATVRSSFANQGEI
CCHHHHHHCCCCCCE		20.1528857561
362PhosphorylationGEGVDKLSLPARNQA
CCCCCCCCCCCCCCC		37.7428355574
385PhosphorylationITDIKDESCCMTEEI
EEECCCCCCCCCCCH		23.8130576142
389PhosphorylationKDESCCMTEEIFGPV
CCCCCCCCCCHHCCE		19.2930576142
426PhosphorylationLAATVWSSNVGRVHR
EEEEHHHCCHHHHHH		21.5928857561
437"N6,N6-dimethyllysine"RVHRVAKKLQSGLVW
HHHHHHHHHHCCCHH		41.86-
437MethylationRVHRVAKKLQSGLVW
HHHHHHHHHHCCCHH		41.8623644510
463PhosphorylationPFGGMKSSGIGREGA
CCCCCCCCCCCCCCC		28.9823403867
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AL8A1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AL8A1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AL8A1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
RUSD2_HUMANRPUSD2physical
26186194
MMSA_HUMANALDH6A1physical
26186194
SMC4_HUMANSMC4physical
26186194
MED15_HUMANMED15physical
26186194
SSDH_HUMANALDH5A1physical
26344197
DPP3_HUMANDPP3physical
26344197
ESTD_HUMANESDphysical
26344197
PEPL1_HUMANNPEPL1physical
26344197
MMSA_HUMANALDH6A1physical
28514442
RUSD2_HUMANRPUSD2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AL8A1_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83, AND MASSSPECTROMETRY.

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