AKR2A_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AKR2A_ARATH
• UniProt AC: Q9SAR5
• Protein Name: Ankyrin repeat domain-containing protein 2A {ECO:0000303|PubMed:18193034}
• Gene Name: AKR2A {ECO:0000303|PubMed:18193034}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 342
• Subcellular Localization: Cytoplasm . Nucleus . Plastid, chloroplast outer membrane ; Peripheral membrane protein ; Cytoplasmic side .
• Protein Description: Exhibits chaperone activity toward chloroplast outer envelope membrane, mitochondrion outer membrane, endoplasmic reticulum membrane and peroxisomal proteins, by recruiting specific proteins containing a single transmembrane associated with an AKR2A-binding sequence (ABS) and subsequently binding glycolipids (e.g. monogalactosyldiacylglycerol (MGDG) and phosphatidylglycerol (PG)) present in the membrane of the target organelle. [PubMed: 18193034]
• Protein Sequence: MASNSEKNPLLSDEKPKSTEENKSSKPESASGSSTSSAMPGLNFNAFDFSNMASILNDPSIREMAEQIAKDPAFNQLAEQLQRSIPNAGQEGGFPNFDPQQYVNTMQQVMHNPEFKTMAEKLGTALVQDPQMSPFLDAFSNPETAEHFTERMARMKEDPELKPILDEIDAGGPSAMMKYWNDPEVLKKLGEAMGMPVAGLPDQTVSAEPEVAEEGEEEESIVHQTASLGDVEGLKAALASGGNKDEEDSEGRTALHFACGYGELKCAQVLIDAGASVNAVDKNKNTPLHYAAGYGRKECVSLLLENGAAVTLQNLDEKTPIDVAKLNSQLEVVKLLEKDAFL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	SEKNPLLSDEKPKST CCCCCCCCCCCCCCC		25561503
18	Phosphorylation	LSDEKPKSTEENKSS CCCCCCCCCCCCCCC		27545962
19	Phosphorylation	SDEKPKSTEENKSSK CCCCCCCCCCCCCCC		27545962
328	Phosphorylation	IDVAKLNSQLEVVKL CCHHHHHHHHHHHHH		25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AKR2A_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AKR2A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AKR2A_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APX3_ARATH	APX3	physical	20215589
CYB5B_ARATH	CB5-B	physical	20215589
NB5R1_ARATH	CBR	physical	20215589
HS178_ARATH	AT1G07400	physical	21730198
TOC33_ARATH	TOC33	physical	20418952
TC159_ARATH	TOC159	physical	25203210
TC753_ARATH	TOC75-III	physical	25203210

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.