AKAP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AKAP3_HUMAN
• UniProt AC: O75969
• Protein Name: A-kinase anchor protein 3
• Gene Name: AKAP3
• Organism: Homo sapiens (Human).
• Sequence Length: 853
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, acrosome. Ribs of the fibrous sheath in the principal piece of the sperm tail. Dorsal margin of the acrosomal segment.
• Protein Description: May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction..
• Protein Sequence: MSEKVDWLQSQNGVCKVDVYSPGDNQAQDWKMDTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPGESFGGETSNSGDPHKGFSVDYYNTTTKGTPERLHFEMTHKEIPCQGPRAQLGNGSSVDEVSFYANRLTNLVIAMARKEINEKIDGSENKCVYQSLYMGNEPTPTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRVSGSSQSPPNLKYKSTLKIKESTKERQGPDDKPPSKKSFFYKEVFESRNGDYAREGGRFFPRERKRFRGQERPDDFTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKDTTIATILLKKVLLKHAKEVVSDLIDSFLRNLHSVTGTLMTDTQFVSAVKRTVFSHGSQKATDIMDAMLRKLYNVMFAKKVPEHVRKAQDKAESYSLISMKGMGDPKNRNVNFAMKSETKLREKMYSEPKSEEETCAKTLGEHIIKEGLTLWHKTQQKECKSLGFQHAAFEAPNTQRKPASDISFEYPEDIGNLSLPPYPPEKPENFMYDSDSWAEDLIVSALLLIQYHLAQGGRRDARSFVEAAGTTNFPANEPPVAPDESCLKSAPIVGDQEQAEKKDLRSVFFNFIRNLLSETIFKRDQSPEPKVPEQPVKEDRKLCERPLASSPPRLYEDDETPGALSGLTKMAVSQIDGHMSGQMVEHLMNSVMKLCVIIAKSCDASLAELGDDKSGDASRLTSAFPDSLYECLPAKGTGSAEAVLQNAYQAIHNEMRGTSGQPPEGCAAPTVIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAAAVDKGCSVGEVLQSVLRYEKERQLNEAVGNVTPLQLLDWLMVNL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSEKVDWLQ ------CCHHHHHHH	46.23	25693802
10	Phosphorylation	EKVDWLQSQNGVCKV HHHHHHHHCCCEEEE	24.36	30622161
20	Phosphorylation	GVCKVDVYSPGDNQA CEEEEEEECCCCCCC	12.51	30622161
21	Phosphorylation	VCKVDVYSPGDNQAQ EEEEEEECCCCCCCC	23.43	30622161
34	Phosphorylation	AQDWKMDTSTDPVRV CCCCCCCCCCCHHHH	29.99	50564367
35	Phosphorylation	QDWKMDTSTDPVRVL CCCCCCCCCCHHHHH	26.92	50564373
36	Phosphorylation	DWKMDTSTDPVRVLS CCCCCCCCCHHHHHH	46.55	50564379
43	Phosphorylation	TDPVRVLSWLRRDLE CCHHHHHHHHHHHHH	22.62	68743225
52	Phosphorylation	LRRDLEKSTAEFQDV HHHHHHHCCCHHCCC	24.39	30622161
53	Phosphorylation	RRDLEKSTAEFQDVR HHHHHHCCCHHCCCE	41.07	30622161
66	Phosphorylation	VRFKPGESFGGETSN CEECCCCCCCCCCCC	34.80	30622161
71	Phosphorylation	GESFGGETSNSGDPH CCCCCCCCCCCCCCC	36.16	30622161
72	Phosphorylation	ESFGGETSNSGDPHK CCCCCCCCCCCCCCC	25.38	30622161
74	Phosphorylation	FGGETSNSGDPHKGF CCCCCCCCCCCCCCE	44.32	30622161
82	Phosphorylation	GDPHKGFSVDYYNTT CCCCCCEEEEEEECC	23.81	30622161
85	Phosphorylation	HKGFSVDYYNTTTKG CCCEEEEEEECCCCC	9.10	30622161
86	Phosphorylation	KGFSVDYYNTTTKGT CCEEEEEEECCCCCC	11.11	30622161
88	Phosphorylation	FSVDYYNTTTKGTPE EEEEEEECCCCCCCC	21.52	30622161
89	Phosphorylation	SVDYYNTTTKGTPER EEEEEECCCCCCCCE	23.91	30622161
90	Phosphorylation	VDYYNTTTKGTPERL EEEEECCCCCCCCEE	25.99	25693802
93	Phosphorylation	YNTTTKGTPERLHFE EECCCCCCCCEEEEE	24.43	30622161
102	Phosphorylation	ERLHFEMTHKEIPCQ CEEEEEEECCCCCCC	23.69	68710007
104	Acetylation	LHFEMTHKEIPCQGP EEEEEECCCCCCCCC	48.44	25038526
119	Phosphorylation	RAQLGNGSSVDEVSF CCCCCCCCCHHHHHH	31.05	30622161
120	Phosphorylation	AQLGNGSSVDEVSFY CCCCCCCCHHHHHHH	34.68	30622161
125	Phosphorylation	GSSVDEVSFYANRLT CCCHHHHHHHHHHHH	15.53	25693802
156	Phosphorylation	GSENKCVYQSLYMGN CCCCCCHHHHHHCCC	11.23	30622161
158	Phosphorylation	ENKCVYQSLYMGNEP CCCCHHHHHHCCCCC	12.09	30622161
160	Phosphorylation	KCVYQSLYMGNEPTP CCHHHHHHCCCCCCC	14.28	30622161
166	Phosphorylation	LYMGNEPTPTKSLSK HHCCCCCCCCCCHHH	37.09	30622161
168	Phosphorylation	MGNEPTPTKSLSKIA CCCCCCCCCCHHHHH	35.43	30622161
170	Phosphorylation	NEPTPTKSLSKIASE CCCCCCCCHHHHHHH	40.11	30622161
172	Phosphorylation	PTPTKSLSKIASELV CCCCCCHHHHHHHHH	29.16	30622161
176	Phosphorylation	KSLSKIASELVNETV CCHHHHHHHHHHHHH	34.63	30622161
182	Phosphorylation	ASELVNETVSACSRN HHHHHHHHHHHHHCC	17.98	30622161
184	Phosphorylation	ELVNETVSACSRNAA HHHHHHHHHHHCCCC	30.86	30622161
187	Phosphorylation	NETVSACSRNAAPDK HHHHHHHHCCCCCCC	28.43	30622161
198	Phosphorylation	APDKAPGSGDRVSGS CCCCCCCCCCCCCCC	36.14	30622161
203	Phosphorylation	PGSGDRVSGSSQSPP CCCCCCCCCCCCCCC	33.57	30243723
205	Phosphorylation	SGDRVSGSSQSPPNL CCCCCCCCCCCCCCC	20.07	24972180
206	Phosphorylation	GDRVSGSSQSPPNLK CCCCCCCCCCCCCCC	37.90	29978859
208	Phosphorylation	RVSGSSQSPPNLKYK CCCCCCCCCCCCCCC	44.25	27050516
214	Phosphorylation	QSPPNLKYKSTLKIK CCCCCCCCCEEEEEC	17.21	46161401
225	Acetylation	LKIKESTKERQGPDD EEECHHHCCCCCCCC	61.24	30586841
236	Phosphorylation	GPDDKPPSKKSFFYK CCCCCCCCHHHHHHH	62.33	30622161
237	Acetylation	PDDKPPSKKSFFYKE CCCCCCCHHHHHHHH	59.20	12431243
242	Phosphorylation	PSKKSFFYKEVFESR CCHHHHHHHHHHHHC	12.29	25693802
243	Acetylation	SKKSFFYKEVFESRN CHHHHHHHHHHHHCC	42.09	25038526
253	Phosphorylation	FESRNGDYAREGGRF HHHCCCCCCCCCCCC	14.68	30622161
319	Acetylation	TIATILLKKVLLKHA HHHHHHHHHHHHHHH	37.07	25038526
331	Phosphorylation	KHAKEVVSDLIDSFL HHHHHHHHHHHHHHH	31.69	25693802
336	Phosphorylation	VVSDLIDSFLRNLHS HHHHHHHHHHHHHHH	21.13	24043423
343	Phosphorylation	SFLRNLHSVTGTLMT HHHHHHHHHHCCCCC	25.25	24719451
345	Phosphorylation	LRNLHSVTGTLMTDT HHHHHHHHCCCCCCH	27.71	24043423
347	Phosphorylation	NLHSVTGTLMTDTQF HHHHHHCCCCCCHHH	12.18	24043423
350	Phosphorylation	SVTGTLMTDTQFVSA HHHCCCCCCHHHHHH	38.72	24043423
352	Phosphorylation	TGTLMTDTQFVSAVK HCCCCCCHHHHHHHH	18.10	24043423
356	Phosphorylation	MTDTQFVSAVKRTVF CCCHHHHHHHHHHHH	28.74	24719451
371	Phosphorylation	SHGSQKATDIMDAML CCCCHHHHHHHHHHH	32.85	23403867
400	Acetylation	HVRKAQDKAESYSLI HHHHHHHHHHHHCCH	41.81	25038526
403	Phosphorylation	KAQDKAESYSLISMK HHHHHHHHHCCHHCC	25.53	22817900
404	Phosphorylation	AQDKAESYSLISMKG HHHHHHHHCCHHCCC	10.05	22817900
405	Phosphorylation	QDKAESYSLISMKGM HHHHHHHCCHHCCCC	28.62	30622161
408	Phosphorylation	AESYSLISMKGMGDP HHHHCCHHCCCCCCC	21.53	30622161
426	Phosphorylation	NVNFAMKSETKLREK CCCHHCCCCHHHHHH	37.10	30622161
428	Phosphorylation	NFAMKSETKLREKMY CHHCCCCHHHHHHHH	42.33	46161395
433	Ubiquitination	SETKLREKMYSEPKS CCHHHHHHHHCCCCC	36.38	-
435	Phosphorylation	TKLREKMYSEPKSEE HHHHHHHHCCCCCHH	22.43	29116813
436	Phosphorylation	KLREKMYSEPKSEEE HHHHHHHCCCCCHHH	43.88	30622161
440	Phosphorylation	KMYSEPKSEEETCAK HHHCCCCCHHHHHHH	62.04	50377
444	Phosphorylation	EPKSEEETCAKTLGE CCCCHHHHHHHHHHH	22.50	30622161
448	Phosphorylation	EEETCAKTLGEHIIK HHHHHHHHHHHHHHH	22.82	30622161
455	Acetylation	TLGEHIIKEGLTLWH HHHHHHHHHCCCHHH	45.16	25038526
471	Phosphorylation	TQQKECKSLGFQHAA HCHHHHHHHCCCCHH	45.44	30622161
504	Phosphorylation	PEDIGNLSLPPYPPE CCCCCCCCCCCCCCC	42.71	26074081
508	Phosphorylation	GNLSLPPYPPEKPEN CCCCCCCCCCCCCCC	29.49	26074081
549	Phosphorylation	GGRRDARSFVEAAGT CCCCCHHHHHHHHCC	35.05	30622161
556	Phosphorylation	SFVEAAGTTNFPANE HHHHHHCCCCCCCCC	17.53	30622161
557	Phosphorylation	FVEAAGTTNFPANEP HHHHHCCCCCCCCCC	33.66	30622161
571	Phosphorylation	PPVAPDESCLKSAPI CCCCCCCHHHHCCCC	31.93	30622161
575	Phosphorylation	PDESCLKSAPIVGDQ CCCHHHHCCCCCCCH	26.74	30622161
592	Phosphorylation	AEKKDLRSVFFNFIR HHHHHHHHHHHHHHH	30.49	25693802
603	Phosphorylation	NFIRNLLSETIFKRD HHHHHHHHHHHHCCC	35.54	30622161
605	Phosphorylation	IRNLLSETIFKRDQS HHHHHHHHHHCCCCC	28.47	30622161
608	Acetylation	LLSETIFKRDQSPEP HHHHHHHCCCCCCCC	51.74	25038526
612	Phosphorylation	TIFKRDQSPEPKVPE HHHCCCCCCCCCCCC	35.20	28985074
635	Phosphorylation	LCERPLASSPPRLYE HHCCCCCCCCCCCCC	51.57	22817900
636	Phosphorylation	CERPLASSPPRLYED HCCCCCCCCCCCCCC	33.06	10529264
641	Phosphorylation	ASSPPRLYEDDETPG CCCCCCCCCCCCCCC	20.70	30622161
646	Phosphorylation	RLYEDDETPGALSGL CCCCCCCCCCHHHHH	33.73	30622161
651	Phosphorylation	DETPGALSGLTKMAV CCCCCHHHHHHHHHH	31.09	30622161
654	Phosphorylation	PGALSGLTKMAVSQI CCHHHHHHHHHHHHC	23.46	30622161
687	Phosphorylation	LCVIIAKSCDASLAE HHHHHHHHCCHHHHH	14.28	30622161
691	Phosphorylation	IAKSCDASLAELGDD HHHHCCHHHHHHCCC	18.18	30622161
699	Acetylation	LAELGDDKSGDASRL HHHHCCCCCCCHHHH	62.16	25038526
700	Phosphorylation	AELGDDKSGDASRLT HHHCCCCCCCHHHHH	49.23	30622161
704	Phosphorylation	DDKSGDASRLTSAFP CCCCCCHHHHHHHCC	32.34	30622161
707	Phosphorylation	SGDASRLTSAFPDSL CCCHHHHHHHCCCHH	19.52	30622161
708	Phosphorylation	GDASRLTSAFPDSLY CCHHHHHHHCCCHHH	32.29	30622161
713	Phosphorylation	LTSAFPDSLYECLPA HHHHCCCHHHHHCCC	32.84	30622161
715	Phosphorylation	SAFPDSLYECLPAKG HHCCCHHHHHCCCCC	14.46	30622161
723	Phosphorylation	ECLPAKGTGSAEAVL HHCCCCCCCCHHHHH	27.53	30622161
725	Phosphorylation	LPAKGTGSAEAVLQN CCCCCCCCHHHHHHH	23.83	24719451
734	Phosphorylation	EAVLQNAYQAIHNEM HHHHHHHHHHHHHHH	13.16	24719451
744	Phosphorylation	IHNEMRGTSGQPPEG HHHHHCCCCCCCCCC	21.22	30622161
745	Phosphorylation	HNEMRGTSGQPPEGC HHHHCCCCCCCCCCC	37.95	30622161
756	Phosphorylation	PEGCAAPTVIVSNHN CCCCCCCEEEEECCC	20.38	30622161
760	Phosphorylation	AAPTVIVSNHNLTDT CCCEEEEECCCCCHH	22.65	30622161
765	Phosphorylation	IVSNHNLTDTVQNKQ EEECCCCCHHHHHHH	34.64	30622161
767	Phosphorylation	SNHNLTDTVQNKQLQ ECCCCCHHHHHHHHH	20.82	30622161
783	Phosphorylation	VLQWVAASELNVPIL HHHHHHHHHCCCCEE	32.64	30622161
791	Phosphorylation	ELNVPILYFAGDDEG HCCCCEEEEECCCHH	7.66	30622161
807	Phosphorylation	QEKLLQLSAAAVDKG HHHHHHHHHHHHHCC	11.69	30622161
816	Phosphorylation	AAVDKGCSVGEVLQS HHHHCCCCHHHHHHH	41.65	30622161
823	Phosphorylation	SVGEVLQSVLRYEKE CHHHHHHHHHHHHHH	20.96	25693802

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AKAP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AKAP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AKAP3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SP17_HUMAN	SPA17	physical	15257753
AKAP4_HUMAN	AKAP4	physical	12606363
KAP2_HUMAN	PRKAR2A	physical	10319321
KAP2_HUMAN	PRKAR2A	physical	11278869
ROP1L_HUMAN	ROPN1L	physical	11278869
ROP1A_HUMAN	ROPN1	physical	11278869

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of capacitated human sperm. Evidence oftyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation.";
Ficarro S., Chertihin O., Westbrook V.A., White F., Jayes F.,Kalab P., Marto J.A., Shabanowitz J., Herr J.C., Hunt D.F.,Visconti P.E.;
J. Biol. Chem. 278:11579-11589(2003).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-205; SER-208; SER-403;TYR-404; SER-440; SER-612; SER-635 AND SER-636, AND MASS SPECTROMETRY.
PubMed: 12509440